Hygiene Prevention Research Articles

Influence of the Enterovirus 71 Vaccine and the COVID-19 Pandemic on Hand, Foot, and Mouth Disease in China Based on Counterfactual Models: Observational Study.

Hand, foot, and mouth disease (HFMD) is a highly contagious viral illness. Understanding the long-term trends of HFMD incidence and its epidemic characteristics under the circumstances of the enterovirus 71 (EV71) vaccination program and the outbreak of COVID-19 is crucial for effective disease surveillance and control. We aim to give an overview of the trends of HFMD over the past decades and evaluate the impact of the EV71 vaccination program and the COVID-19 pandemic on the epidemic trends of HFMD. Using official surveillance data from the Yunnan Province, China, we described long-term incidence trends and severity rates of HFMD as well as the variation of enterovirus proportions among cases. We conducted the autoregressive integrated moving average (ARIMA) of time series analyses to predict monthly incidences based on given subsets. The difference between the actual incidences and their counterfactual predictions was compared using absolute percentage errors (APEs) for periods after the EV71 vaccination program and the COVID-19 pandemic, respectively. The annual incidence of HFMD fluctuated between 25.62 cases per 100,000 people in 2008 and 221.52 cases per 100,000 people in 2018. The incidence for men ranged from 30 to 250 cases per 100,000 people from 2008 to 2021, which was constantly higher than that for women. The annual incidence for children aged 1 to 2 years old ranged from 54.54 to 630.06 cases per 100,000 people, which was persistently higher than that for other age groups. For monthly incidences, semiannual peaks were observed for each year. All actual monthly incidences of 2014 to 2015 fell within the predicted 95% CI by the ARIMA(1,0,1)(1,1,0)[12] model. The average APE was 19% for a 2-year prediction. After the EV71 vaccination program, the actual monthly incidence of HFMD was consistently lower than the counterfactual predictions by ARIMA(1,0,1)(1,1,0)[12], with negative APEs ranging from -11% to -229% from January 2017 to April 2018. In the meantime, the proportion of EV71 among the enteroviruses causing HFMD decreased significantly, and the proportion was highly correlated (r=0.73, P=.004) with the severity rate. After the onset of the COVID-19 pandemic in 2020, the actual monthly incidence of HFMD consistently maintained a lower magnitude compared to the counterfactual predictions-ARIMA(1,0,1)(0,1,0)[12]-from February to September 2020, with considerable negative APEs (ranging from -31% to -2248%). EV71 vaccination alleviated severe HFMD cases and altered epidemiological trends. The HFMD may also benefit from nonpharmaceutical interventions during outbreaks such as the COVID-19 pandemic. Further development of a multivalent virus vaccine is crucial for effectively controlling HFMD outbreaks. Policymakers should implement nonpharmaceutical interventions and emphasize personal hygiene for routine prevention when appropriate.

Investigating the Impact of Health-Protective Behaviors on Morbidity and non-Morbidity COVID-19 among Workers in Oil Refining Industry Using Machine Learning algorithms

Introduction: The prevalence of COVID-19 has significantly impacted work environments and the workforce. Therefore, identifying the most important preventive and control strategies, as well as assessing their effectiveness, is of paramount importance. Various studies have shown that machine learning algorithms can be used to predict complex and nonlinear issues, including predicting the behavior of various diseases such as COVID-19 and the parameters affecting it, and can be beneficial. The purpose of this study has been to examine the importance of preventive measures and hygiene behaviors in preventing COVID-19 in the oil refining industry using various machine learning models. Material and Methods: For this purpose, demographic information and health behaviors of individuals were collected. Subsequently, a multi-layer perceptron (MLP), radial basis function (RBF), and support vector machine (SVM) models were compared to enhance the analysis of the effects of preventive measures on COVID-19 infection. Finally, the most influential factors affecting the likelihood of COVID-19 infection were determined using sensitivity analysis. Results: The results showed that the accuracies achieved in predicting the impact of preventive measures and health behaviors on COVID-19 in occupational settings were 78.1%, 81.2%, and 78.1% by MLP, RBF, and SVM respectively. The RBF model was identified as the most accurate model for predicting the impact of health behaviors on COVID-19 disease Additionally, the level of social distancing with customers, handwashing frequency and disinfection, the availability of cleansing and disinfecting agents for hands and surfaces in the workplace, and gatherings for eating meals and snacks were identified as the most significant health behaviors influencing the prevalence of COVID-19 in the workplace. Conclusion: Studies of this nature can underscore the importance of attention to preventive measures and health behaviors in unprecedented circumstances. Furthermore, the utilization of artificial intelligence models and tools such as DSS (Decision Support Systems) can serve as powerful tools for optimizing control measures in work environments.

Trend of hand, foot and mouth disease before, during, and after China's COVID control policies in Zhejiang, China.

To describe the trends in the incidence of hand, foot and mouth disease (HFMD) before, during, and after China's Coronavirus Disease (COVID) control policies, and to interpret the influence on HFMD incidence at different control stages in Zhejiang Province. We collected data on HFMD cases in Zhejiang between 2014 and 2023. We compared the constituent ratios of cases at different COVID control stages by sex, age, child groups, and pathogens and weekly seasonal indices to observe seasonal variations in the incidence of HFMD. An interrupted time-series segmented regression analysis was applied to estimate the influence on HFMD incidence at different control stages. Stratified and sensitivity analyses were conducted to validate the findings. A considerable proportion of cases occurred among children living separately. The proportions of children in kindergartens or nurseries and children aged 2-4 years were relatively low at the strict control stage compared to the other three stages. Enteroviruses other than enterovirus 71 and coxsackie virus A16 were the dominant HFMD pathogens, and the proportion showed an increasing trend. The usual spring-summer peak in HMFD incidence did not occur in 2020, and the periodicity of the biennial peak was disrupted for a year. The summer peak in 2023 was higher than that in the other years, and was delayed by 3 weeks. The trend changes in weekly HFMD cases during the strict control and regular control stages were - 15% (IRR: 0.85, 95% CI: 0.81-0.89) and 17% (IRR: 1.17, 95% CI: 1.12-1.23), respectively. However, the change was not statistically significant during the reopening stage (IRR: 1.41, 95% CI: 0.34-5.88). The expected number of cases increased by 1.12 times (95% CI: 243.17, 53.45%) during the reopening stage compared to what would have occurred if the zero-COVID policy had continued in 2023. Non-pharmaceutical interventions (NPIs) for COVID-19 control can mitigate HFMD. However, after the dynamic zero-COVID policy ended, the HFMD incidence returned to historical levels. Strict NPIs such as traffic restrictions and kindergarten closures cannot be sustained long-term. NPIs such as improving personal hygiene for routine prevention are highly recommended.

Cost estimation of preventive dental hygiene care using Time-Driven Activity-Based Costing (TDABC)

Objectives: This study used Time-Driven Activity-Based Costing (TDABC) to measure the value of preventive dental hygiene care and offering a more practical and adaptable cost management method than compared to traditional cost accounting approaches.. Methods: A descriptive survey was conducted using 164 questionnaires collected from dental hygienists actively involved in preventive dental care. The cost data related to labor, materials, and overheads, were anlyzed using detailed classifications of procedures such as scaling, fluoride application, and sealant application. Results: The total allocated cost of 10,163,355 South Korean Won (KRW) was divided by the total working time of the dental clinic (23,520 min), providing a unit cost of 432 KRW/min. Among the three preventive dental care procedures, scaling had the highest total activity cost of 5,867,243 KRW. Conclusions: This study provides valuable evidence for the implementation of an appropriate fee system for preventive dental care performed by dental hygienists. Therefore, this study contributes to the establishment of a fair and rational reimbursement structure.

Enhancing Public Health: training an AI chatbot for complex tasks support

Abstract Background The evolution of Large Language Models (LLMs) such as GPT-4, Gemini, and Copilot has transformed the field of Natural Language Processing, demonstrating human-level capabilities and potential applications in Public Health. Here, we report on the training of a chatbot model based on GPT-4 designed to assist operators with relevant and complex public health tasks. Methods A scoping review of existing studies on the application of LLMs in Public Health settings was conducted to understand the landscape and identify gaps in their current implementations. We then proceeded to analyse the necessary skills and competencies required for public health professionals to adequately instruct the model on required tasks. Finally, we selected the Italian regulations and guidelines with the greatest relevance in the public health field to provide the knowledge base to the model. Results The review revealed no relevant documents on the use of LLMs in areas related to Public Health. Skills and competencies were retrieved from the Guidelines of the Italian Society of Hygiene for Public Health operators and used to instruct the model on how to address public health tasks. As for the knowledge base, we retrieved 25 documents regulating specific areas of the public health field, such as vaccinations, hygiene and safety at work, infection prevention, and school hygiene. Such documents were used to train the model, after formatting them appropriately. Conclusions Despite challenges with non-standardized and technically complex documentation, preliminary testing of our model has shown its versatility and utility in supporting daily public health operations. A validation phase is under definition and will involve a DELPHI process, in which products of the custom GPT model will be evaluated by a panel of public health operators to evaluate its performance in real-world settings, ensuring compliance with national health regulations. Key messages • Training a GPT-4-based chatbot to support complex tasks in Public Health, tailored by relevant national guidelines. • Our custom model, informed by public health guidelines, showed potential in preliminary tests.

Natural and socio-cultural factors of epidemics (plague, smallpox): The example of the Adyghe population of the Northwest Caucasus

Background. The article discusses the problem of the impact of epidemic diseases on ethnogenesis. As an ancient agricultural ethnic group in contact with nomadic and Mediterranean populations, the Adyghe were formed during periods of frequent epidemics of dangerous diseases caused by the process of animal domestication and subsequent impact of anthropogenic factors. The devastating effect of smallpox and measles pandemics was felt following the establishment of intensive trade exchange during the 2nd century CE by the Roman and the Han empires. The first plague pandemic (beginning with the “Justinianic Plague”, 542–543) mostly affected the Balkans and the Eastern Mediterranean. The second plague pandemic, the so-called “Black Death” (1346–1353), which appeared in the center of the Mongol Empire, quickly spread via caravan routes across most of Eurasia. The scale of the epidemic was influenced by the pathogenic complex that had developed by the 14th century, which included humans, the bacterial pathogenic agent itself, and its carriers (large rodents especially black rats, fleas). Factors such as famine caused by overpopulation, low standards of personal and public hygiene, the prevalence of wooden buildings in cities and towns, the fur trade, etc., also had contributory effects. Objectives. The study set out to identify the natural and the socio-cultural factors that influenced the spread of the plague and the smallpox epidemics in the North-West Caucasus. Methods. The data on which this study is based are formed from collections of narrative sources (Russian, Arabic-Persian, European), archaeological and historical-anthropological works, medical and genetic studies (electronic platforms: eLIBRARY.RU, Academia.edu, CyberLeninka, J-STAGE [Japan Science Technology Information Aggregator, Electronic]). Research methods: historical and comparative, on which basis a comparative analysis of the impact of the plague pandemic of the mid-14th century centering on contact between on nomadic and sedentary ethnic groups (Mongols and Russians, Mongols and Circassians) was carried out; the individualizing comparison method, which was used to identify the specific means by which the Circassian ethnic group overcame the Black Death pandemic; the systems analysis method, on which basis the roles of pathogenic complex and anthropogenic factors in the course of epidemics were compared. Results. The results of the analysis show that the population of the North-West Caucasus were affected by the Black Death plague of the mid-14th century to a significantly lesser extent than the urban centers of the Golden Horde, Rus’ and Europe. The serendipitous failure of the pathogenic complex in the former region was due to the following natural and anthropogenic factors: (1) the North-West Caucasus (more precisely, the entire area to the west of the Teberda River) was naturally bereft of effective carriers of the plague bacillus (marmots, gophers, etc.); (2) Matrega and Copa, the two contemporaneous Circassian towns serving as ports for the shipment of grain and other agricultural products, were located on the periphery of the Adyghe settlement area; (3) the dispersed, farmstead way of life among the estuaries and the complex network of peninsulas of the Kuban Delta, mountains and forests of the NWC contributed to the rapid adoption of quarantine measures; (4) a reliable vitamin-rich nutrition system (sturgeon and their caviar, goat meat and cheese, fruit, honey, etc.); (5) a well-developed system of hygiene and disease prevention (smallpox, malaria), whose existence was retrospectively established based on sources from the 17th–19th centuries. Conclusion. The plague pandemic that took place within the unified space of Mongol imperial communications had a huge impact on the historical fate of the Adyghe ethnic group, which was manifested in their paradoxical numerical growth against the backdrop of general depopulation. Against the backdrop of frequent epidemics, Adyghe developed strict and quite effective rules for preserving life and health, covering disease prevention, personal and public hygiene. Some particularly impressive practices, if not created by Adyghe folk medicine, then preserved there and later transmitted to Ottoman Turkey and Western Europe, was manifested in the original practice of smallpox inoculation.

Tobacco industry corporate social responsibility activities and other interference after ratification of a strong tobacco law in Ethiopia

BackgroundSince strict new tobacco control laws were introduced in 2019 and 2020, the National Tobacco Enterprise (NTE), the main manufacturer and distributor of cigarettes in Ethiopia, strategically engaged in corporate...

Using self‐management strategies to improve toothbrushing for adults in supported community living

AbstractHygiene is an important area related to personal health and socialization. Regular toothbrushing can prevent painful procedures related to tooth decay and gum disease and reduce bad breath and plaque that may interfere with social and professional acceptance. Unfortunately, many individuals with disabilities do not engage in regular and thorough preventative dental hygiene, placing them at risk for oral disease. Using a multiple baseline design, three participants who independently brushed their teeth but did not brush frequently or thoroughly were taught to self‐evaluate and record using a self‐management (SM) checklist. The findings of this study suggest that SM may be a helpful method for improving the frequency and quality of toothbrushing. Outcomes regarding supporting individuals to achieve maximal independence in these essential life skills are discussed.

Covid-19 vaccination status and beliefs of individuals with co-occurring serious mental illness and alcohol use disorder

ObjectiveThe study objective was to determine factors associated with obtaining COVID-19 vaccination in people with co-occurring alcohol use disorder (AUD) and serious mental illness (SMI). MethodsSurvey responses were obtained from 135 adults with SMI seeking community-based AUD treatment about their primary series vaccination status, COVID-19 preventative practices, vaccination motivators, reasons for vaccine hesitancy, and strategies to increase vaccination uptake. Vaccinated and unvaccinated groups were compared. Responses to survey items with nominal or Likert scales were analyzed with chi-square tests of association. Logistic regression was employed to determine predictors of vaccine status. ResultsSeventy-nine percent (n=107) of participants reported they were vaccinated. A higher proportion of vaccinated participants believed COVID-19 was a serious disease. While both groups adopted preventative hygiene practices at similar rates (e.g., washing hands), vaccinated participants engaged in more interpersonal practices directly involving others (e.g., wearing masks and avoiding crowds). The strongest vaccine motivator was protecting personal health, while the primary reason for hesitancy was potential side effects. Most unvaccinated participants endorsed increased safety information availability (61.1 %) and living with a high-risk-for-severe-infection individual (55.6 %) as reasons to overcome hesitancy. ConclusionsVaccination rates, motivators, and hesitancy reasons were similar to the general United States population. Strategies to increase vaccination in this high-risk population should include education on vaccine safety and side effects and the impacts of COVID-19 and other respiratory illnesses on others.

Beyond the distance between juridic and scientific decision-making process: An evidence-based prediction algorithm for professional liability assessment in healthcare-associated infections

BackgroundHAIs (Healthcare-Acquired-Infections) have been recently the subject of judgment n. 6386 pronounced on 3rd March 2023 by the Italian Supreme Court. This sentence provided three criteria to determine whether a health facility is responsible for the patient contracting a nosocomial infection, i.e. time criterion, topographical criterion and clinical criterion. Accordingly, the healthcare facility is obliged to prove the fulfillment of a series of preventive hygiene measures specifically detailed by the legislator. Herein, the positive predictive value of these criteria (“juridic criteria”) in the identification of professional liability for nosocomial infections was evaluated in comparison with clinical criteria reviewed by Infectious Disease specialists (“Infectious-Disease criteria”, i.e. presence of a Multidrug Resistant Organism (MDRO); development of surgical site infection; inadequate antibiotic therapy; inadequate disinfection). MethodsTwo retrospective cohorts were compared from the Portal of Telematic Services of the Ministry of Justice; 51 patients were extrapolated from Italian judgments concerning claims for Gram-negative nosocomial infections in the three-year period 2020–2022. On the other side, from the electronic database of University Hospital of Bari we extracted 349 patients affected by Gram-negative infections in the same timespan. Both “juridic” criteria and “Infectious-Disease” criteria were then applied to the full cohort after stratification for cohort of origin and after stratification for nosocomial or non-nosocomial infections. Predictive value of criteria was evaluated through receiver operating characteristic (ROC) curves and area under the curve (AUC). ResultsOverall, the incidence of definite nosocomial infections (according to final judgement or clinical records discharge letter) was 84 % in juridic cohort and 46 % in “real-world” series.Data suggested that the presence of all three juridic criteria [ROC AUC = 0.944 (95%CI = 0.924–0.963)] or the four clinical criteria [ROC AUC = 0.948 (95%CI = 0.928–0.969)] predicted well a case of nosocomial infection with professional liability.Moreover, by summarizing both criteria in a single classification system, the generated ROC curve (was the one with the highest AUC [0.9488 (95%CI = 0.928–0.969)].Accordingly, further tests were performed, evaluating the predictive value of one juridic criterium plus at one of more Infectious-Disease criteria. Interestingly, the ROCs curves demonstrated that the presence of at least 1 juridic criteria plus at least 2 Infectious Disease criteria reached a predictive value comparable to 2 or 3 juridic criteria. ConclusionsThe results highlight the efficiency of new criteria laid down in the judgment of the Italian Supreme Court to attribute liability for nosocomial infection despite the disputed distance between juridic and scientific decision-making process. In addition, the use of a combined score combining “juridic” and “Infectious-Disease” criteria provides a high-quality tool to be used by technical consultants to make up for lack of clinical documentation by passing judgments concerning litigation about professional liability in case of nosocomial infections. This sheds light on the possibility to face worldwide judicial inquiries with scientific rigor.

Systematic Review on Oral Health Knowledge, Practice and Attitude In Pakistan

Background: The term "oral health" describes the state of the mouth's defence against ailments that affect the oral cavity, such as tooth decay, periodontal disease, cancer of the mouth and throat, facial discomfort, and ulcers. Oral cleanliness, tobacco usage, alcohol consumption, and general diet are the main contributors to oral health issues and illnesses. The most significant advantage of maintaining proper dental hygiene is the prevention of diseases. In Pakistan, dental health is not given much priority. The aim of this systematic review is to thoroughly examine and summaries the body of research on Pakistani people's attitudes, practices, and knowledge on oral health. The study aims to identify knowledge gaps, offer a thorough review of the existing situation regarding oral health awareness, habits, and attitudes, and indicate possible areas for development. Methods: This thorough systematic review, which adheres closely to PRISMA principles, examines all cross-sectional studies examining the gaps in oral health knowledge, practice, and attitude in Pakistan. Several databases such as Medline, ProQuest Central, Web of Science, and Scopus were used and past and current reviews on the same subject were looked in the Cochrane Database of Systematic Reviews. Selected papers were meta-synthesized to produce results that were both statistically sound and strong. Results: The findings reveal that there are differences in the population's knowledge about oral health, certain groups with low socio-economic status showing less understanding of preventive and good oral hygiene habits. Conclusion: This review highlights the need for all-encompassing strategies that account for differences in geography, culture, and socioeconomic disparities by placing the findings in a broader literary context. To improve oral health outcomes across the country, specific public health campaigns, educational programmes, and policy measures are crucial given the knowledge gaps and practice discrepancies that have been discovered. By addressing these problems, we can improve people's general health and lessen the prevalence of oral disorders in Pakistan.

Change in parental knowledge and beliefs about early childhood dental caries following a pragmatic community-based trial.

To evaluate parent knowledge and belief changes following the MySmileBuddy (MSB) early childhood caries (ECC) intervention. Pre- and post-intervention surveys were completed by 669 parents of children with visually-evident ECC from among 977 participants in a 6-12-month pragmatic community-based caries management trial administered by community health workers (CHWs). Six domains of knowledge about caries and motivating and facilitating determinants were assessed via 26 survey items. Principal components analysis and reliability testing reduced dataset dimensionality. Parent and CHW characteristics were analyzed as potential moderators. Paired T-tests measured pre-to-post-intervention changes. Generalized estimating equations accounted for within-participant correlation with significance set at p < 0.05. Twenty items consolidated into five factors (saliva, hygiene, diet, seriousness/susceptibility, and outcome expectations). Six additional items were evaluated individually. Positive post-intervention changes (p < 0.0001) were observed across all factors and all but one individual item (tooth decay is very common). Greatest knowledge increases related to caries as a bacterial disease in two measures, the saliva factor and a single caries belief item tooth decay is an infectious disease (0.59 unit increase, 95% CI [0.55, 0.64] and 0.46 unit increase, 95% CI [0.4, 0.51], respectively), and in the value of fluoridated water over bottled (0.46 unit increase, 95% CI [0.39-0.53]). Most parents improved knowledge of ECC salivary (72%) and dietary risks (57%), and preventative hygiene behaviors (59%). MSB enhanced knowledge and beliefs about caries and confirmed hypothesized mediators of behavior change among parents of high-risk children. Engaging peer-like CHW interventionists may have moderated intervention effects, warranting further exploration.

Main characteristics of preventive postural hygiene training programs in the educational field

Objective: To determine the state of the art regarding preventive training programs on postural hygiene and back health in an educational context. Introduction: The prevalence of non-specific back pain in population reaches alarming figures and its causes are largely preventable. Adequate training in postural education is necessary along students' academic career. Method: Retrospective descriptive study, using the PRISMA method. Results: 61 original articles published from 2017 to 2021 have been analysed. Discussion: Postural education programs have demonstrated their effectiveness and have provided benefits for the participating students.

Potential Hepatitis a Analysis: Research on Healthy and Safe Lifestyles in Indonesian Education in Taiwan

Purpose: This research aims to develop a predictive model using the Health Belief Model behavioral theory approach to understand changes in eating habits and physical activity among Indonesian students in Taiwan. Given the historical context of hepatitis A outbreaks in Taiwan and the importance of preventive health behaviors, the study seeks to lay the foundation for further intervention research focused on promoting healthy lifestyles among Indonesian students. Methods: The research employs a basic research approach to develop a predictive model, drawing on the Health Belief Model framework. Data collection involves administering questionnaires to Indonesian students in Taiwan to assess their eating habits, physical activity, knowledge about hepatitis A prevention, and adherence to Clean and Healthy Living Behavior (PHBS) practices. Statistical analysis is conducted to identify factors influencing knowledge and behavior related to hepatitis A prevention. Results and Discussion: Analysis of questionnaire data from 112 Indonesian students reveals that many behaviors do not reflect PHBS practices aimed at preventing hepatitis A transmission. The results indicate that factors such as age, gender, and level of education significantly influence knowledge about hepatitis prevention and healthy hygiene behavior. Specifically, higher levels of knowledge correlate with better preventive behaviors, suggesting the importance of educational interventions in promoting health awareness among students. Implications of the Research: The findings have implications for public health interventions targeting Indonesian students in Taiwan to prevent hepatitis A transmission and promote healthy lifestyles. By identifying factors influencing knowledge and behavior related to hepatitis prevention, the research provides insights for developing targeted interventions and educational campaigns aimed at improving health outcomes among this population. Originality/Value: This research contributes to the literature by applying the Health Belief Model framework to understand and predict changes in eating habits and physical activity among Indonesian students in Taiwan. The study addresses the need for preventive health measures in response to hepatitis outbreaks and underscores the importance of cultural and contextual factors in shaping health behaviors among international student populations. The findings provide a basis for future intervention research and highlight the significance of promoting health awareness and preventive practices in diverse cultural settings.

Food Security and Foodborne Mycotoxicoses-What Should Be the Adequate Risk Assessment and Regulation?

The purpose of this review is to elucidate the actual threat of the most prevalent mycotoxins in agricultural commodities and human/animal food/feed for the induction of foodborne diseases or ailments. The underestimated hazard of combined mycotoxin uptake by animals or humans is critically discussed with regard to synergistic or additive interaction between some target mycotoxins. The real toxicity of target mycotoxin combinations as it happens in practice is evaluated and possible lower limit values or control measures are suggested in such cases. Some critical points on adequate risk assessment, hygiene control, and regulation of mycotoxins are discussed. The efficiency of current mycotoxin regulations and control measures is evaluated in regard to human/animal health hazards. The risk assessment in the case of multiple mycotoxin exposure of humans/animals via food/feed or agricultural commodities is evaluated and some suggestions are proposed in such cases. Appropriate control measures and food safety issues throughout the food supply chain are proposed in order to prevent the target foodborne diseases. Some preventive measures and possible veterinary hygiene controls or risk evaluations are proposed in some natural cases of foodborne diseases for preventing mycotoxin contamination of animal products designed for human consumption and to avoid possible public health issues.

Subgingival microbial changes in Down Syndrome adults with periodontitis after chlorhexidine adjunct non-surgical therapy and monthly recalls–A 12-month case series study

ObjectivesDown Syndrome (DS) adults are at risk for periodontitis. Previous reports indicated difficulties in periodontopathogen reduction or eradication in DS individuals after periodontal treatment. This case series follows the subgingival microbial changes in adult DS individuals with periodontitis who received chlorhexidine adjunct non-surgical therapy plus 12-month recalls. MethodsTwenty periodontitis DS participants (7 females; 25.5 ± 5.6 years of age; 3 with generalized periodontitis) partook in a study involving non-surgical mechanical periodontal therapy, twice daily chlorhexidine gel toothbrushing, chlorhexidine mouthwash, and monthly recalls. The subgingival microbiota profile was followed at baseline, 6-, and 12-months post-operation. ResultsDesulfobulbus, Saccharibacteria (TM7), Tannerella, and Porphyromonas were the major subgingival genera in this DS cohort. Favorable chlorhexidine adjunct non-surgical treatment outcomes were observed, with the relative abundance of Desulfobulbus sp. HMT 041, Saccharibacteria (TM7) [G-1] bacterium HMT 346 or 349, and Tannerella forsythia significantly reduced at the end of the study, but no significant reduction of Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans could be observed. Relative abundance of Desulfobulbus sp. HMT 041 and T. forsythia were also found to be significantly associated with plaque, bleeding on probing, and probing pocket depth (PPD, in mm) at a site level, while the relative abundance of Halomonas pacifica was negatively associated with PPD. ConclusionsSuccessful chlorhexidine adjunct non-surgical treatment with hygiene care was accompanied by a subgingival microbial shift involving certain periodontopathogenic species, except P. gingivalis and A. actinomycetemcomitans. Further investigations are required to clarify the mechanism underpinning the unchanged relative abundance of the above two pathogens despite favorable clinical responses. Clinical SignificanceDS adults face challenges achieving optimal home care or hygiene for periodontal healing and disease prevention. Chemical adjunct mechanical periodontal therapy plus regular recalls appeared promising clinically and microbiologically, with subgingival periodontopathogenic species reduction. The persistence of A. actinomycetemcomitans and P. gingivalis in subgingival niches post-treatment warrants further investigation.

Antimicrobial Resistance and Sports: The Scope of the Problem, Implications for Athletes' Health and Avenues for Collaborative Public Health Action.

Antimicrobial resistance (AMR) poses a global threat, leading to increased mortality and necessitating urgent action-however, its impact on athletes and the world of sports has hitherto been neglected. Sports environments (including athletic and aquatic) exhibit high levels of microbial contamination, potentially contributing to the spread of resistant microorganisms during physical activities. Moreover, the literature suggests that travel for sports events may lead to changes in athletes' gut microbiomes and potentially impact their antibiotic resistance profiles, raising questions about the broader implications for individual and public/global health. The prevalence of Staphylococcus aureus (S. aureus) among athletes (particularly those engaged in contact or collision sports) ranges between 22.4% and 68.6%, with MRSA strains being isolated in up to 34.9% of tested individuals. Factors such as training frequency, equipment sharing, delayed post-training showers, and a history of certain medical conditions are linked to higher colonization rates. Moreover, MRSA outbreaks have been documented in sports teams previously, highlighting the importance of implementing preventive measures and hygiene protocols in athletic settings. In light of the growing threat of AMR, there is a critical need for evidence-based treatment guidelines tailored to athletes' unique physiological demands to ensure responsible antibiotic use and mitigate potential health risks. While various initiatives-such as incorporating AMR awareness into major sporting events-aim to leverage the broad audience of sports to communicate the importance of addressing AMR, proactive measures (including improved AMR surveillance during large sporting events) will be indispensable for enhancing preparedness and safeguarding both athletes' and the general public's health. This narrative review thoroughly assesses the existing literature on AMR and antibiotic usage in the context of sports, aiming to illuminate areas where information may be lacking and underscoring the significance of promoting global awareness about AMR through sports.

PASQUALE - A long-term partnership to improve hand hygiene and capacity building in infection prevention and control in the Faranah region of Guinea

Across the globe, hand hygiene (HH) is promoted to fight the spread of healthcare associated infections. Despite multiple ongoing HH campaigns and projects, the healthcare associated infection rates remain high especially in low- and middle-income countries. In the narrative overview presented here, we aim to share objectives, framework, successes and challenges of our long-term partnership in Guinea to offer guidance for other projects aiming to sustainably improve HH.

Long-Term Prevalence Trends in Children in Relation to Environmental Issues in the Astrakhan Region

Introduction: One of the tasks of preventive medicine and hygiene is to study the relationship between environmental factors and human health. The purpose of the study was to compare pediatric prevalence rates in the Astrakhan Region and in the city of Astrakhan in 2007–2020 with those for the Russian Federation in relation to per capita emissions of environmental pollutants. Materials and methods: We used official statistics on the size of population, prevalence rates in children, and emissions of air pollutants in the Astrakhan Region for the years under study. Methods of mathematical and statistical analysis, construction of trend lines and calculation of linear regression equations using built-in Microsoft Excel software were applied. An online Spearman’s Rho Calculator was used to compute correlation coefficients. Results: The prevalence in children showed a statistical downward trend both in Astrakhan and in the Astrakhan Region as a whole with its rates being, on average, 7.8 % and 15.6 % lower than the national ones, respectively. The Spearman’s Rho (rs) showed the presence of a high and direct statistically significant correlation between per capita emissions of air pollutants and disease prevalence in the child population in the Astrakhan Region (rs = 0.73; p = 0.003) with a moderate direct, yet insignificant, correlation for the Russian Federation as a whole (rs = 0.32; p = 0.41) and null correlation for the data computed for the of Astrakhan (rs = 0.26; p = 0.32). Conclusion: Along with the predicted decreasing trend in prevalence in the pediatric population, we established a statistical relationship between local environmental problems and children’s health, which should be taken into account in the development of disease prevention programs.

Behavioral Change Interventions in Dental Hygiene for Prevention of Dental Caries in Children at SDN 09 North Pontianak

Behavioral Change Interventions in Dental Hygiene for Prevention of Dental Caries in Children at SDN 09 North Pontianak