Hydroxyapatite-coated Implants Research Articles

Long-Term Evaluation of Hydroxyapatite-Coated Implants: Paradigm for Success

Long-Term Evaluation of Hydroxyapatite-Coated Implants: Paradigm for Success

Efficacy of threaded hydroxyapatite-coated implants placed in the posterior mandible in support of fixed prostheses

Efficacy of threaded hydroxyapatite-coated implants placed in the posterior mandible in support of fixed prostheses

EFFICACY OF THREADED HYDROXYAPATITE-COATED IMPLANTS PLACED IN THE POSTERIOR MANDIBLE IN SUPPORT OF FIXED PROSTHESES

A data subset from an ongoing prospective multicenter clinical study of threaded hydroxyapatite-coated implants was evaluated to assess safety and efficacy of the implants when used to support fixed prostheses in the posterior mandible. Observations were recorded before surgery, at first-stage surgery, at second-stage surgery, at loading, and at quarterly postrestoration prophylactic exams and annual comprehensive patient visits. Implant failure criteria included mobility, radiographic evidence of bone loss greater than one-third the length of the implant or peri-implant radiolucency, fracture, exfoliation, removal for any reason, and patient reported pain upon palpation. Soft tissue indices were monitored as part of the study. Postrestoration implant performance was analyzed using life-table methodology. From the 2,062 implants restored in 720 patients in the parent study, a total of 423 implants in 195 patients were included in the posterior mandibular data subset. Thirteen implants failed at or before second-stage surgery for a surgical success rate of 96.9 percent. Prosthodontics was completed, and one or more postrestoration annual follow-up visits occurred for 314 implants as of the interim analysis cutoff date. Fourteen implants failed during an observation period extending up to 62 months after completion of prosthodontic treatment. One failed implant was removed, whereas the 13 remaining implants are functional despite having been identified as failures under the protocol criteria. The Cutler-Ederer life table success rate after 5 years was 92.2 percent. Results of this investigation suggest that threaded hydroxyapatite-coated implants are effective when placed in posterior mandibular regions in support of fixed prostheses.

Efficacy of threaded hydroxyapatite-coated implants in the anterior mandible supporting overdentures

Efficacy of threaded hydroxyapatite-coated implants in the anterior mandible supporting overdentures

When to Use Hydroxyapatite-Coated Implants

When to Use Hydroxyapatite-Coated Implants

Performance of Maxillary Hydroxyapatite-Coated and Non-Coated Implants at Second-Stage Surgery

Performance of Maxillary Hydroxyapatite-Coated and Non-Coated Implants at Second-Stage Surgery

A Comparison of Hydroxyapatite-Coated Micro-Vent and Pure Titanium Swede-Vent Implants in Humans

A Comparison of Hydroxyapatite-Coated Micro-Vent and Pure Titanium Swede-Vent Implants in Humans

Heat generation in hydroxyapatite-coated implants as a result of CO 2 laser application

Previous studies have demonstrated that heat may induce bone resorption and minimize the regenerative capacity of bone. This finding is of potential clinical importance because the carbon dioxide laser may often be used to surgically expose dental implants. However, little is known about the actual amount of heat generated at the implant-bone interface. This experiment measured heat generation on the surface of dental implants exposed to the carbon dioxide laser. A total of 90 trials were performed. A complete factorial (3 x 3 x 2) experimental design was used to evaluate the interactions among laser wattage output (4, 8, and 15 watts), duration of exposure time (1, 5, or 15 seconds) and variations in emission conditions (pulsed or continuous laser mode). Linear increases in temperature to temperatures greater than 50 degrees C were observed with increases in wattage output or duration of exposure time. The pulse mode generated significantly less heat. The results of this study suggest that caution should be used when using the carbon dioxide laser for second stage dental implant surgery.

The effect of warfarin on the attachment of bone to hydroxyapatite-coated and uncoated porous implants.

The attachment of bone to hydroxyapatite-coated and uncoated porous implants made of cobalt-chromium-molybdenum alloy was investigated with and without postoperative administration of warfarin sodium. The implants were placed transcortically in the femoral diaphysis of adult female goats and were evaluated after three, six, and twelve weeks in situ. Mechanical push-out testing and histological evaluation revealed that the attachment strength and the ingrowth of bone at the bone-implant interface increased with time in situ for both the hydroxyapatite-coated and the uncoated implants. The administration of warfarin significantly impaired both the attachment strength and the ingrowth of bone at twelve weeks. At twelve weeks, the attachment strength and bone ingrowth of the hydroxyapatite-coated implants in the animals that had received warfarin were statistically equal to those of the uncoated implants in the control animals.

The effect of operative fit and hydroxyapatite coating on the mechanical and biological response to porous implants.

Femoral intramedullary implants were constructed by threading 4.0-millimeter-thick disks with a titanium-alloy (Ti-6Al-4V) porous bead coating onto a two-millimeter-diameter threaded rod. Each porous-coated disk, which was 6.0, 8.0, 9.0, or 10.0 millimeters in diameter, was separated by a two-millimeter-thick acrylic disk with a diameter of ten millimeters. Implants with and without a hydroxyapatite coating of twenty-five micrometers were inserted into fifteen skeletally mature adult mongrel dogs. The femoral canal was sequentially reamed bilaterally to a ten-millimeter diameter, resulting in uniform initial implant-bone interface gaps of 0.0, 0.5, 1.0, and 2.0 millimeters. Each animal received paired hydroxyapatite-coated and uncoated implants. Three animals each were killed at four, eight, twelve, twenty-four, and fifty-two weeks after the implantation. The harvested femora were sectioned through the acrylic spacers, transverse to the long axis, to produce individual push-out test specimens for mechanical testing. Characteristics of interface attachment were determined with test fixtures that supported the surrounding bone to within 150 micrometers of the interface. Histological sections were prepared, and the amount of bone within the porous structure and the amount of the original gap that was filled with new bone were quantified with a computerized video image-analysis system. Mechanical attachment strength and bone ingrowth were found to increase with the time after implantation and with a decrease in the size of the gap. Placement of the implant in proximal (cancellous) compared with distal (cortical) locations had no significant effect on the strength of attachment, bone ingrowth, or gap-filling. However, implants with a large initial gap (1.0 or 2.0 millimeters) demonstrated greater attachment strength in cancellous bone than in cortical bone. With a few exceptions, hydroxyapatite-coated implants with an initial gap of 1.0 millimeter or less demonstrated significantly increased mechanical attachment strength and bone ingrowth at all time-periods. Interface attachment strengths were positively correlated with bone ingrowth, the time after implantation, the use of a hydroxyapatite coating, and decreasing initial gap size. Initial implant-bone apposition is thought to be a prerequisite for good biological fixation. This apposition is often not achieved because of the design of the implant or instruments and the operative technique. Poor initial fit during the operation may decrease the longevity of the implant. The results of the present study indicate that attachment strength and bone ingrowth are significantly affected by gaps in the interface, particularly those of more than 1.0 millimeter.(ABSTRACT TRUNCATED AT 400 WORDS)

When to Use Hydroxyapatite-Coated Implants: A Clinical Perspective

When to Use Hydroxyapatite-Coated Implants: A Clinical Perspective

Performance of Maxillary Hydroxyapatite-Coated and Non-Coated Implants at Second-Stage Surgery

Performance of Maxillary Hydroxyapatite-Coated and Non-Coated Implants at Second-Stage Surgery

A Comparison of Hydroxyapatite-Coated Micro-Vent and Pure Titanium Swede-Vent Implants in Humans

A Comparison of Hydroxyapatite-Coated Micro-Vent and Pure Titanium Swede-Vent Implants in Humans

EFFICACY OF THREADED HYDROXYAPATITE-COATED IMPLANTS PLACED IN THE ANTERIOR MAXILLA

A data subset from an ongoing prospective multicenter clinical study of threaded hydroxyapatite-coated implants was evaluated to assess safety and efficacy of the implants in anterior maxillary regions when used to support fixed prostheses. Observations were recorded before surgery, at first-stage surgery, at second-stage surgery, at loading, and at quarterly post-restoration prophylactic exams and annual comprehensive patient visits. Of 2,062 implants restored in 720 patients in the parent study, a total of 95 implants in 54 patients met the criteria for inclusion into this portion. Implant failure criteria included mobility, radiographic evidence of bone loss greater than one-third the length of the implant or peri-implant radiolucency, fracture, exfoliation, removal for any reason, and patient reported pain upon palpation. Soft tissue indices were monitored as part of the study. Post-restoration implant performance was analyzed using life-table methodology. No failures were observed before prosthodontic rehabilitation. Three implants failed during an observation period of up to 5 years after completion of prosthodontic treatment. The Cutler-Ederer life table success rate after 5 years was 93.4 percent. Results of this investigation suggest that threaded hydroxyapatite-coated implants are safe and effective when placed in anterior maxillary regions to support fixed prostheses.

Efficacy of threaded hydroxyapatite-coated implants placed in the anterior maxilla

Efficacy of threaded hydroxyapatite-coated implants placed in the anterior maxilla

Bioactive ceramics

The Journal of Bone and Joint Surgery. British volumeVol. 76-B, No. 6 ArticlesFree AccessBioactive ceramicsP DucheyneP DucheyneSearch for more papers by this authorPublished Online:1 Nov 1994https://doi.org/10.1302/0301-620X.76B6.7983107AboutSectionsPDF/EPUB ToolsAdd to FavouritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited ByBiomedical Applications of Inorganic Biomaterials30 March 2022Zein-based composites in biomedical applications27 March 2017 | Journal of Biomedical Materials Research Part A, Vol. 105, No. 6Hydroxyapatite scaffolds constituting highly oriented crystals derived from synthetic precursors by hydrothermal reactionsCeramics International, Vol. 42, No. 15In Vitro Resorbability of Three Different Processed Hydroxyapatite1 August 2015 | Key Engineering Materials, Vol. 659Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior18 February 2015 | Journal of Biomaterials Applications, Vol. 30, No. 1Pulsed laser deposition of hydroxyapatite on nanostructured titanium towards drug eluting implantsMaterials Science and Engineering: C, Vol. 33, No. 5The next generation of biomaterial development28 April 2010 | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 368, No. 1917Biomimetic nanostructured coatings on nano-grained/ultrafine-grained substrate: Microstructure, surface adhesion strength, and biosolubilityMaterials Science and Engineering: C, Vol. 29, No. 8In vitro biological characterization of macroporous 3D Bonelike® structures prepared through a 3D machining techniqueMaterials Science and Engineering: C, Vol. 29, No. 3Implant Surface Treatment Using Biomimetic AgentsImplant Dentistry, Vol. 18, No. 1Materials viewpoints in bone regenerative medicine: progress and prospects19 July 2013 | Materials Science and Technology, Vol. 24, No. 9In vitro response of hFOB cells to pamidronate modified sodium silicate coated cellulose scaffoldsColloids and Surfaces B: Biointerfaces, Vol. 64, No. 2A new in vivo screening model for posterior spinal bone formation: Comparison of ten calcium phosphate ceramic material treatmentsBiomaterials, Vol. 27, No. 3Effects of bone morphogenetic protein-2 and hyaluronic acid on the osseointegration of hydroxyapatite-coated implants: An experimental study in sheepJournal of Biomedical Materials Research Part A, Vol. 73A, No. 3Biomechanical and histomorphometric study on the bone–screw interface of bioactive ceramic-coated titanium screwsBiomaterials, Vol. 26, No. 16Calcium Phosphate Coatings for Implant FixationA Novel Polymer-Synthesized Ceramic Composite Based System for Bone Repair: Osteoblast Growth on Scaffolds with Varied Calcium Phosphate Content1 February 2011 | MRS Proceedings, Vol. 845Relative Contributions of Chemistry and Topography to the Osseointegration of Hydroxyapatite CoatingsClinical Orthopaedics and Related Research, Vol. 405Influence of coating strain on calcium phosphate thin-film dissolution1 January 2001 | Journal of Biomedical Materials Research, Vol. 57, No. 1Nanophase ceramics: The future orthopedic and dental implant materialUse of β-tricalcium phosphate in foot and ankle surgery: a report of 20 casesFoot and Ankle Surgery, Vol. 7, No. 4Enhancement of human osteoblast proliferation and phenotypic expression when cultured in human serum8 July 2009 | Acta Orthopaedica Scandinavica, Vol. 72, No. 4Comblement des pertes de substance osseuse par le phosphatetricalcique β en traumatologie*11Communication présentée à l’Académie nationale de chirurgie au cours de la séance du 12 avril 2000.Annales de Chirurgie, Vol. 125, No. 10Editor's Note: This is the eighth in a series of state-of-the-art papers covering all aspects of craniofacial care. To be published throughout volumes 36 and 37 of the CPCJ, these papers will reflect on where we have been, where we are now, and the challenges we face in the new millennium.The Cleft Palate-Craniofacial Journal, Vol. 37, No. 1Bone Substitutes15 December 2017 | The Cleft Palate-Craniofacial Journal, Vol. 37, No. 1Porous-coated versus grit-blasted surface texture of hydroxyapatite-coated implants during controlled micromotionThe Journal of Arthroplasty, Vol. 13, No. 4Chemical modification of titanium surfaces for covalent attachment of biological moleculesJournal of Biomedical Materials Research, Vol. 40, No. 2Resorption of hydroxyapatite and fluorapatite ceramic coatings on weight-bearing implants: A quantitative and morphological study in dogsJournal of Biomedical Materials Research, Vol. 39, No. 1Hydroxyapatite and Fluorapatite Coatings for Fixation of Weight Loaded ImplantsClinical Orthopaedics and Related Research, Vol. 336Improved fixation of porous-coated versus grit-blasted surface texture of hydroxyapatite-coated implants in dogs8 July 2009 | Acta Orthopaedica Scandinavica, Vol. 68, No. 4Mini-review: Proactive biomaterials and bone tissue engineering26 March 2000 | Biotechnology and Bioengineering, Vol. 50, No. 4 Vol. 76-B, No. 6 Metrics Downloaded 85 times History Published online 1 November 1994 Published in print 1 November 1994 InformationCopyright © 1994, The British Editorial Society of Bone and Joint Surgery: All rights reservedPDF download

Effect of diclofenac on fixation of hydroxyapatite-coated implants. An experimental study

We studied the effect of non-steroidal anti-inflammatory drugs on the fixation of hydroxyapatite-coated implants. Cylindrical plugs of pure titanium, coated with hydroxyapatite (HA), were inserted into both femora of 10 adult rabbits, 5 of which received 7 daily doses of 30 mg diclofenac. Three weeks after implantation the interface strengths were measured by the pull-out test. The mean peak force for the diclofenac-treated group was 290 +/- 57 N compared with 369 +/- 37 N for the control group (p < 0.025). We conclude that the inhibitory effect of diclofenac on bone repair is not neutralised by HA-coating of an implant.

Histological observations of coated and prestressed dental implants under flexible or rigid loading conditions

Hydroxyapatite-coated and hydroxyapatite-prestressed titanium implants were implanted under load-free, flexible-loaded and rigid-loaded conditions in dog mandibula in vivo. The bone response, bone contact and the quality of the coating were evaluated histologically and histometrically. Hydroxyapatite coating on titanium implants enhanced the bone apposition. The bone contact can still be present while the coating is resorbed. Gingiva contact with the coating led to a faster degradation of the coating. There was no significant difference in bone contact between hydroxyapatite-coated and -prestressed implants with regard to the loading systems: rigid, flexible and load-free. All three implants showed the highest amount of bone contact apically. Only at the mesial side of the implant did the flexible element show rather high amounts of bone contact compared to the rigid and load-free implants. The hydroxyapatite coating more or less degraded during the implantation period. The degree of degradation varied in the implant itself, between the implants and between the animals.

Bone response to hydroxyapatite‐coated and commercially pure titanium implants in the human arthritic knee

Rough and smooth commercially pure (c.p.) titanium implants and hydroxyapatite-coated (HA-C) implants were inserted in arthritic human knees and left in situ in order to compare the response of bone to these three implants. Radiographic examination alone could not determine if bone apposition had occurred. After 3 and 6 months, histomorphometric analyses of undecalcified sections, 10 microns thick, revealed a statistical significance in the amount of bone apposition to rough-surfaced and HA-C implants as compared with smooth uncoated implants. Most of the rough-surfaced c.p. titanium implants and the HA-C implants had achieved bone apposition on the order of 50%. No statistically significant differences in apposition were seen between the rough-surfaced and HA-C implants. The smooth c.p. titanium implants were mostly encapsulated in fibrous tissue.

Immediate insertion of two types of implants into vascularized bone grafts used for mandibular reconstruction in miniature pigs

Reaction of bone tissue was investigated after placement of two different types of implants in vascularized iliac bone grafting. After the mandibles of six Go¨ttingen minipigs were reconstructed with vascularized bone of the iliac crest, hydroxyapatite-coated implants and titanium screw implants were placed in the graft. The animals were killed at 14, 28, and 56 days after the implantation, and the healing processes were examined histologically. In the vascularized bone graft, new bone formed well around the implants, but some of the implant surfaces were covered with soft tissue by advancing bone resorption. The results suggest that a hydroxyapatite-coated implant as well as a titanium screw-type implant might be applied with a vascularized bone graft for jaw reconstruction. However, implants placed simultaneously with the vascularized bone graft had less osteointegration than implants placed in nongrafted control sites.