Anion-exchange membrane fuel cells (AEMFCs) allow for the use of Pt-free or precious group metal (PGM-free) catalysts and for a wider choice of cell and stack materials. Currently, there are still development challenges, such as the need to improve the efficiency of anode catalysts, due to the sluggish hydrogen oxidation reaction (HOR) in alkaline electrolytes. It has been demonstrated that the HOR rate can be improved using bifunctional materials, which have both an optimized hydrogen binding energy (HBE) and a favorable OHads binding energy (OHBE) [1,2]. In literature, experimental and theoretical studies demonstrate that HOR electrochemical activity of PdCu alloys strongly depends on their crystalline structure, which can be tuned through thermal treatment (300-600°C) modifying the Body-Centered Cubic (BCC) and Face-Centered Cubic (FCC) phase ratio [3-5]. On this basis, a FCC-phased PdCu(1:1) alloy supported on Vulcan XC-72 was synthesized via a metal-vapor method (MVS) and furtherly modified through thermal annealing (5 hours under N2 atmosphere) in order to obtain the appearance of an ordered BCC structure. The HOR performance and stability of these materials were tested for first time in a complete in AEMFC. The use of PdCu allows us to lower the effective Pd loading on the electrode to about 0.16 mg cm-2, obtaining in the case of PdCu/C-500°C (where FCC-BCC phases coexist) a maximum power density of 941 mW/cm2. The increased activity and stability of the PdCu/C-500°C was demonstrated through long stability test, where it exhibits an average of 685 mW/cm2 of power density over 15 hours of testing during 3 days in AEMFC fixed at a constant potential of 0.4 V and 80°C (H2 0.5 L/min, O2 1 L/min), 10% more of the FCC-phased PdCu. Moreover, acquiring a final scan of potential at the end of the experiments, it is clear that PdCu/C 500°C suffers of a minor drop of performances (only of 19%), respect with disordered FCC-phased PdCu which efficiency in terms of maximum power density drops of 30% (Figure 1). Figure 1