Hydrophobic Structure Research Articles

Structure–property relationships of cationic polyurethane surfactants: Impact on surface activity and anticorrosion performance

Three cationic polyurethane surfactants (LC1–1, LC2–2, and LC2–3), each featuring different hydrophobic structures, were synthesized using isophorone diisocyanate, N-methyl diethanolamine, 1-bromohexadecane, and 1-bromobutane. The synthesized cationic polyurethane surfactants exhibited low surface tension, excellent foaming properties, and resistance to salt, attributed to steric hindrance among long-chain alkyl groups and their “multi-point anchoring” ability. The corrosion inhibition performance of polyurethane surfactants on carbon steel in 1 M HCl solution was evalutated, and LC2–2 showing a considerable corrosion inhibition efficiency of 97.0 %. This film effectively reduced/isolated contact between the corrosive solution and the steel interface. Furthermore, quantum chemical calculations corroborated the electrochemistry experiment results, affirming that the molecular structure of LC2–2 is particularly conducive to inhibiting the corrosion of carbon steel. This study explores the relationship between the molecular structure of surfactants and its impact on both surface activity and corrosion inhibition efficiency.

A thiol-anchored solvatochromic and fluorogenic molecular rotor for covalent protein labeling in SDS-PAGE and mitochondria specific fluorescence imaging.

Fluorescent labeling is a widely used method for protein detection and fluorescence imaging. A solvatochromic and fluorogenic molecular rotor DASPBCl was developed for covalent protein labeling in solution and SDS-PAGE, and also for stable mitochondria labeling and fluorescence imaging. The dye DASPBCl consisted of a 4-(N,N-dimethylamino)phenyl moiety as the electron donor and a positively charged N-benzylpyridinium moiety as the electron acceptor. A benzyl chloride group was introduced into the pyridine moiety for covalent labeling of thiol in proteins. When the fluorescent dye DASPBCl is covalently labeled to the thiol of proteins, significantly enhanced fluorescence was obtained, which is attributed to the polarity sensitivity caused solvatochromic effect from the hydrophobic protein structure and the viscosity sensitivity caused fluorogenic effect from the restriction of single bond rotation. DASPBCl exhibits high sensitivity and good linear response for protein detection in SDS-PAGE analysis with both the pre-staining method and post-staining method. DASPBCl was also successfully used for covalently protein-anchored fluorescence imaging of mitochondria in living cells.

Salt thickening performance and mechanism of an N-Vinyl-2-Pyrrolidinone based amphiphilic polymer

Enhancing salt tolerance is a critical requirement for polymer flooding in the petroleum production process. This work introduced a novel salt thickening polymer called NDC16, which is a cationic polymer composed of poly(N-Vinyl-2-Pyrrolidinone-co-Double hexadecyldimethylallyl ammonium chloride). Notably, NDC16 does not contain traditional Acrylamide (AM) or Acrylic acid (AA). Its salt thickening performance and mechanism in sodium chloride and calcium chloride solutions were separately analyzed at aggregation and molecular levels by photophysical method, micromorphology, and molecular dynamics (MD) simulation. The results demonstrated that the novel polymer was able to increase the viscosity of the sodium chloride solution to 20 times higher than the initial one. However, its performance in increasing viscosity in a calcium chloride solution was only half as effective. The inclusion experiments indicated that almost all increasing viscosity could be contributed to the hydrophobic association effects of the polymer molecules. The results of the dynamic analysis revealed that the NDC16 aggregates showed a more orderly arrangement in NaCl solutions, while the network structure appeared as relatively disordered clusters in CaCl2. Besides, there existed an optimal salinity at which the network density of the hydrophobic structure reached the highest level. The variation in thickening performance can be elucidated by the molecular interaction. Due to their smaller molecular interactions, the Na+ ions exhibited a stronger potential to permeate into the polymer clusters. It stretched the polymer molecules and allowed them to display a structured arrangement. The large Radius of Gyration (Rg) and spatial distance of the polymers in two solutions indicated that the polymer clusters were much elongated in Na+ solvents, thereby confirming their permeation effect. These results enhance the comprehension of the process by which salt thickening occurs due to the interaction between cationic hydrophobic associative polymers and various salt solutions.

Structure-activity relationships of natural and synthetic lathyrane-based diterpenoids for suppression of NLRP3-driven inflammation and gouty arthritis

Lathyrane-based diterpenoid is one of the critical bioactive elements of Euphorbia lathyris L., a widely used traditional Chinese medicine for the treatment of inflammation and infection. In this study, we introduced and evaluated seven synthetic or natural lathyrane-based diterpenoids with the same core structure but notable structural variations at specific positions, for their anti-inflammatory and gout-alleviating properties. There was no significant cytotoxicity below 10 μM among the initial test of the cell counting kit 8 of the seven candidate derivatives (compounds 13 to 19) in this work. Furthermore, maintaining the acyloxy group at 15-C position and the strongly hydrophobic aryl structure at 3-C and 5-C positions, compounds 15 (Euphorbia factor L3, EFL3) and 17 strikingly inhibited the production of IL-1β related to the actuation of the inflammasome in our study. The ELISA assay indicated that the anti-inflammatory effects of EFL3 were better associated with MSU stimulation than other second-line pathways triggered by inflammasome. Further examinations on the acute paw gout model in C57BL/6 mice showed that EFL3 had a significantly inflammatory retarding effect by intraperitoneal injection. It decreased swelling volume as well as the cleavage and activation of local IL-1β and casepas-1 in the paw. To conclude, our findings reveal several potential key structure–activity relationships that govern the anti-inflammatory effects of lathyrane-type diterpenoids, the dispensable acyl group at the 15-C position, the importance of maintaining the spatial structure of the B-ring, and the potential importance of hydrophobic substituents at the 3-C position. These insights may provide guidance for the structural design of lathyrane-type agents in the future; furthermore, we found that the lathyrane-based diterpenoid EFL3 is a potential agent for gout that is expected to provide a novel therapeutic strategy for inflammation intervention.

Rapid differential diagnosis of periprosthetic joint infection by microdroplet reaction on portable biochip and indicator

Periprosthetic joint infection (PJI) is a catastrophic complication after joint arthroplasty. A key step to treat PJI is accurate diagnosis. However, according to the existing guidelines, no biomarker has been used to diagnose PJI alone and autoimmune diseases such as rheumatoid arthritis (RA) often interfere with the diagnosis. Patients with PJI often still face issues such as misdiagnosis and delayed treatment after a comprehensive scoring diagnosis. Thus, a rapid quantitative detection method based on excellent biomarker is needed. Here, an all-printed photonic crystal (PC) biochip is reported. Through the fluorescence enhancement effect of the photonic crystals and the design of the hydrophilic and hydrophobic patterning structure, trace detection of lactoferrin (LTF) in a drop of viscous synovial fluid can be achieved within 10 min by the biochip. The detection limit is as low as 4.6 ng/mL. For more intuitive results, portable testing equipment is developed with indicator light displays of three colors (green = NPJI, yellow = RA, and red = PJI) to indicate the diagnosis depending on the biochip’s fluorescence intensity. Furthermore, 79 clinical synovial fluid samples are tested with PC biochips, and the PC results are in good agreement with the ELISA results. Due to the microdroplet reaction on PCs, biochips are suitable for the detection of the selected markers in the synovial fluid. The use of the three-color portable testing equipment avoids the need for professional testing devices. Overall, this strategy provides a new paradigm for the early and differential diagnoses of PJI.

Interfacial Shear Rheology of the Waxy Oil-Water Interfacial Layer Construction by Span80/60/65: Influence of Hydrophobic Chain Structure

Interfacial Shear Rheology of the Waxy Oil-Water Interfacial Layer Construction by Span80/60/65: Influence of Hydrophobic Chain Structure

CO2-responsive polymer promoted by polyether to efficient viscosity increase for CO2 plugging

A novel series of CO2-responsive polymers with unique hydrophobic structures were developed, capable of efficiently increasing viscosity in response to CO2 at low concentrations. These polymers, namely PAD-H, were synthesized by copolymerizing acrylamide, 2-(dimethylamino)ethyl methacrylate, and octadecyl polyoxyethylene ether methacrylate. In parallel, two comparative polymer sets were crafted, lacking the long polyether chains in their hydrophobic structures. DMAEMA imparts CO2-responsiveness through its tertiary amine groups, while the hydrophobic monomer contributes an alkyl structure with polyether long chains. These hydrophilic polyether long chains provide enhanced mobility to the hydrophobic alkyl chains, enabling lower concentration molecular hydrophobic association post CO2 exposure, thus leading to an increase in viscosity. This research delved into the mechanism of CO2-responsive viscosity increase, examining the impact of the polymer's intrinsic structure and external factors on its responsive behavior. Additionally, the polymer was applied in CO2 flooding, a crucial technique in carbon capture, utilization, and storage (CCUS). Simulated reservoir conditions were used to conduct in-situ CO2-responsive viscosity increase tests and CO2 gas channeling plugging experiments, substantially enhancing plugging efficiency. This advancement offers practical materials for addressing gas channeling in CO2 flooding and augments the technical methodologies for carbon utilization and storage within the CCUS framework.

The Role of Lipid Intrinsic Curvature in the Droplet Interface Bilayer.

Model bilayers are constructed from lipids having different intrinsic curvatures using the droplet interface bilayer (DIB) method, and their static physicochemical properties are determined. Geometrical and tensiometric measurements are used to derive the free energy of formation (ΔF) of a two-droplet DIB relative to a pair of isolated aqueous droplets, each decorated with a phospholipid monolayer. The lipid molecules employed have different headgroup sizes but identical hydrophobic tail structure, and each is characterized by an intrinsic curvature value (c0) that increases in absolute value with decreasing size of headgroup. Mixtures of lipids at different ratios were also investigated. The role of curvature stress on the values of ΔF of the respective lipid bilayers in these model membranes is discussed and is illuminated by the observation of a decrement in ΔF that scales as a near linear function of c02. Overall, the results reveal an association that should prove useful in studies of ion channels and other membrane proteins embedded in model droplet bilayer systems that will impact the understanding of protein function in cellular membranes composed of lipids of high and low curvature.

Completely Methylene-Free Side Chain Enables Significant Microphase Separation at Medium IECs for Fuel-Cell Anion Exchange Membranes.

The introduction of hydrophobic side chain structures in anion exchange membranes (AEMs) to facilitate ion transport has been widely studied; however, low or moderate hydrophobic hydrocarbon and semifluorinated side chains are insufficient to induce a high degree of microphase separation. Herein, we design and prepare poly(aryl piperidinium) AEMs with completely methylene-free perfluorinated side chains, which can maximize the thermodynamic incompatibility between main- and side chains, thus enhancing microphase separation at medium ion exchange capacities (IECs). According to the molecular dynamics study, the methylene-free perfluorinated side chain leads to better hydration of cations. The hydroxide conductivity of the methylene-free perfluorinated side chain-grafted PAP-pF-1 membrane reaches 124.9 mS cm-1 at 80 °C, and the PAP-sF-1 with semifluorinated side chains and PAP-CH-1 with hydrocarbon side chains show lower conductivity (116.8 and 104.0 mS cm-1). The H2/O2 fuel cell using the PAP-pF-1 membrane demonstrates a remarkable peak power density (1651 mW cm-2 at 80 °C) and durability (greater than 300 h). This work provides a novel insight into enhancing microphase separation in AEMs; it opens up new possibilities for developing high-performance AEMs.

Synergizing tetra-coordinated Ti sites anchored onto micropore-free silica with Au sites to boost propylene hydro-oxidation

Constructing tetra-coordinated Ti sites on the micropore-free oxide surface as a substitute for the Ti-containing zeolites to synergize with Au sites for propylene epoxidation with H2 and O2 to propylene oxide (HOPO) can solve the problems resulting from micropores but remains a great challenge. Here, we report a facile strategy to anchor tetra-coordinated Ti sites onto micropore-free silica by precisely cleaving the surface hydroxyl and siloxane bridges of silica to generate under-coordinated O sites to bind Ti sites. Multiple spectroscopic characterizations, including ultraviolet Raman, UV–vis and Fourier transformation infrared and 29Si solid nuclear magnetic resonance spectroscopy, demonstrate the anchored Ti sites on the surface of silica are mainly the target tetra-coordinated ones. It is further unveiled that the removal of surface hydroxyl also improves the hydrophobicity of synthesized Ti-SiO2, which enhances the desorption of PO. Benefitting from the weak acidic properties, high hydrophobicity and micropore-free structures, the tetra-coordinated Ti sites on silica synergize well with Au sites in propylene epoxidation, demonstrating high activity, selectivity and stability, which are superior to those achieved on the most extensively researched Au/TS-1 catalysts.

Hydrophobicity of montmorillonite synergistically controlled by silanization and aliphatic amine modification

The hydrophobic modification of montmorillonite significantly extends its potential applications across various industrial sectors. In this study, montmorillonite with controlled hydrophobicity was prepared based on Cu2+-exchanged montmorillonite by synergistic modification with perfluorodecyltrimethoxysilane and aliphatic amines. Our findings indicate that copper ion-exchange process not only increases the interlayer spacing of montmorillonite but also promotes the formation of antlerite crystals on its surface. The presence of interlayer water impedes the silanization process with perfluorodecyltrimethoxysilane, confining the grafting to the external surface of the clay. Consequently, this method can only increase the water contact angle (WCA) from 0° to 54.4°. Conversely, treatment with aliphatic amines removes interlayer water and establishes a hydrophobic structure on the internal surface, raising the WCA to 47.0°. Remarkably, the synergistic modification of perfluorodecyltrimethoxysilane and aliphatic amine resulted in a WCA of 157.3°. Further investigations demonstrated that adjusting the type and concentration of the aliphatic amines allows for precise control of WCA, enabling adjustments within the range of 54.4° to 157.3°. This study offers a viable approach for the controllable hydrophobic modification of montmorillonite.

Regenerated SERS substrate based on Ag/AuNPs-TiO2-oxidized carbon cloth for detection of imidacloprid

Imidacloprid (IMI) are widely used in modern tea industry for pest control, but IMI residues pose a great threat to human health. Herein, we propose a regeneration metal-semiconductor SERS substrate for IMI detection. We fabricated the SERS sensor through the in-situ growth of a nano-heterostructure incorporating a semiconductor (TiO2) and plasmonic metals (Au, Ag) on oxidized carbon cloth (OCC). Leveraging the high-density hot spots, the formed Ag/AuNPs-TiO2-OCC substrate exhibits higher enhancement factors (1.92 × 108) and uniformity (RSD = 7.68%). As for the detection of IMI on the substrate, the limit of detection was lowered to 4.1 × 10−6 μg/mL. With a hydrophobic structure, the Ag/AuNPs-TiO2-OCC possessed excellent self-cleaning performance addressing the limitation of single-use associated with traditional SERS substrates, as well as the degradation capability of the substrate under ultraviolet (UV) light. Accordingly, Ag/AuNPs-TiO2-OCC showcases outstanding SERS sensing and regenerating properties, making it poised for extensive application in the field of food safety assurance.

Development of VEGF mimetic QK peptide on polycaprolactone nanofiber for vascular tissue engineering

Electrospinning allows promoting vascular tissue formation. Polycaprolactone (PCL) is a promising polymer for vascular tissue engineering because of its great mechanical strength and efficient fabrication. However, PCL shows limited biocompatibility owing to its hydrophobic structure. PCL nanofibers can be modified by peptides to improve biological activity. KLTWQELYQLKYKGI (QK) is a peptide that mimics the Vascular Endothelial Growth Factor (VEGF) by organizing endothelial cells. It is critically important to identify the optimum concentration of QK peptide conjugation onto PCL nanofiber for vascularization. Thus, PCL nanofibers were conjugated by different QK peptide concentrations (10 µM, 100 µM and 1000 µM). QK conjugated nanofibers were characterized by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) analysis. The vascularization was evaluated by Live and Dead staining assay, real time PCR of platelet/endothelial cell adhesion molecule (PECAM-1), VEGF and vascular endothelial-cadherin (VE-cadherin) genes and VEGF immunofluorescence analysis. The surfaces of PCL nanofibers were modified by different concentrations of QK peptide. The roughness of nanofibers increased depending on the increased concentration of QK peptide. The higher cell attachment and cell viability were observed in 1000 µM of QK peptide. 1000 µM of QK peptide showed higher vasculogenic potential in terms of PECAM, VEGF, and VE-cadherin gene expression than all the other experimental groups. In the same on gene expression analysis by qPCR, 1000 µM concentration of QK peptide showed the higher VEGF protein than the other experimental groups. 1000 µM concentration of QK peptide can be used to improve the vasculogenic property of PCL nanofibers.

Effects of ultrasound on the structural, physicochemical, and emulsifying properties of aquafaba extracted from various legumes

This study investigated the effect of ultrasound (20–60 min, 40 kHz, 280 W) on the structural, physicochemical, and emulsifying properties of aquafaba extracted from various legumes (chickpea [CH], yellow soybean [YSB], black soybean [BSB], small black bean [SBB]). The hydrophobic amino acids and protein secondary structures (α-helix, random coil) significantly increased with sonication time (p < 0.05). The particle size of aquafaba was reduced by ultrasound (p < 0.05). A total of 27 volatile compounds were identified. Most volatiles increased with sonication time, and beany flavor was lowest in CH and SBB. The EAI, ESI, adsorbed proteins, and zeta-potential increased, while emulsion droplet size decreased in all legumes by ultrasound. The overall emulsifying properties were the highest in SBB sonicated for 40 min. This study discusses the applicability of ultrasound to aquafaba and provides insights into the functional properties and potential of aquafaba as a plant-based natural emulsifier

Preparation and properties of self‐humidifying anodic gas diffusion layer with hydrophilic polymer material

AbstractIn this paper, an anodic gas diffusion layer (GDL) with a gradient hydrophobic structured microporous layer (MPL) was prepared using a spraying method. The hydrophobicity of the MPL was changed by adding polyvinylpyrrolidone to the MPL close to the catalyst layer side to obtain a bilayer MPL with a gradient hydrophobic structure. By performing the above operation, we designed a double‐layer MPL structure with different hydrophobic gradients. In this study, we analyzed the effect of the gradient hydrophobic structure of bilayer MPL on the electrochemical performance of proton exchange membrane fuel cell by characterizing the physical properties, such as water contact angle, of anode self‐humidified GDL prepared in the laboratory. The study compared the limiting power density of the laboratory‐prepared GDL sample 10% with that of the commercial GDL29BC. The limiting power density of the sample 10% is 1.59, 1.5, and 1.49 W/cm2 under three humidity conditions of 40%, 60%, and 100%, respectively, which improve the performance by 19.5%, 17.2%, and 23.1% over that of the commercial GDL29BC. The anode GDL samples prepared in the laboratory showed good self‐wetting effect, which play a positive role in the improvement of fuel cell performance.

Preparation of HTV silicone rubber with hydrophobic–uvioresistant composite coating and the aging research

Abstract A series of high temperature vulcanization (HTV) silicone rubbers with TiO2 ultraviolet (UV) shielding layer and polytetrafluoroethylene (PTFE) hydrophobic layer were prepared via stepwise spray method. It was found that the hydrophobic PTFE liquid emulsion (PTFEL) could steadily and tightly adhere to the HTV silicone rubber surface by spray method after pre-mixing with permanent room temperature vulcanized (PRTV) silicone rubber during the first step spray. And the subsequent introduction of TiO2 and PTEF solid powder (PTFES) could improve the UV shielding ability and further increase the hydrophobicity of HTV silicone rubber during the second step spray after pre-blending. The accelerated hygrothermal aging process and UV aging process were used to analyze the effect of coating structure and composition on anti-aging performance. And the results indicated that the HTV silicone rubber with PRTV-PTFEL/TiO2-PTFES composite coating showed a favorable UV shielding ability and also possessed an excellent hydrophobicity due to the introduction of low surface energy matter and the building of coarse micro-nano hydrophobic structure. After the aging process, the cracked micro-surface, increased water absorption and decreased mechanical property were displayed for the neat HTV silicone rubber, and these aging phenomena got dramatically improved for PRTV-PTFEL/TiO2-PTFES coating HTV silicone rubber.

Preparation and Characterization of pH-sensitive Doxorubicin Grafted Hyaluronic Acid Nano-micelles

Background: This study was done to achieve a new drug delivery system delivering two different chemotherapy molecules to the target tissue simultaneously. Significance: Co-delivery of chemotherapy medicines provides synergistic effects leading to lowering the dose of administered drugs and side effects. Methods: Doxorubicin (DOX) was introduced to water-soluble hyaluronic acid (Hyal) using 1-amino-3,3-diethoxy-propane (ADEP), as a pH-sensitive linker, to develop a new hydrophobic structure, i.e. Hyal-ADEP-DOX. The conjugates were grafted in three ratios (7.5%, 12.5%, and 20%) to Hyal and characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance (1HNMR). Cannabidiol (CBD) was physically loaded in the core of nano-micelles. Results: Prepared nano-micelles were analyzed for critical micelle concentration (CMC) particle size stability and drug release before and after loading the CBD. Hyal-ADEP-DOX-12.5 was the optimized ratio and had a mean diameter of 50 nm before loading the CBD and 120 nm after loading (observed by transmission electron microscopy). The release results showed that DOX releases slowly in physiological pH, and CBD has a burst release at acidic pH from Hyal-ADEP-DOX-12.5. These properties altogether make Hyal-ADEP-DOX nano-micelles, as a stimuli-sensitive nano-carrier, a potential candidate for hydrophobic anticancer agents’ co-delivery. Conclusion: The grafted DOX exhibited pH-sensitive release behavior, i.e. while 22.8% of the drug was released after 24 h at pH 5.5, and 5% was released after 24 h at pH 7.4. Hyal-ADEP-DOX due to its low CMC value, colloidal stability, slow drug release in physiological pH, and burst release in acidic pH Hyal-ADEP-DOX, is an excellent candidate as a carrier to co-deliver hydrophobic therapeutic agents to tumor tissues.

Preparation of SiO2-polydimethylsiloxane-octadecyltrichlorosilane superhydrophobic coating and its self-healing performance

The self-healing performance of superhydrophobic coatings is an important property to enhance the durability and self-cleaning character, which has been a focus of surface modification in recent years. In this work, a simple method was proposed for preparing the superhydrophobic coatings with self-healing properties on slides using nano-SiO2, octadecyltrichlorosilane, and polydimethylsiloxane. The hydrophobic properties, morphologies, compositions, structures, stability, and self-healing properties were respectively investigated via various characterizations and tests. The results indicated that the self-healing properties of the coatings were induced by the Si-O-Si bonds through X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The best self-healing property and hydrophobicity after healing were obtained when the content of polydimethylsiloxane was 35% (wt.), and the contact angle of water would arrive at 160.98° when the concentration of nano-SiO2 was 3% (wt.). The contact angle of each coating surface remained stable and thermally stable when the temperature was increased from 100 to 300 °C ( Tg), and the coatings remained stable under natural acidic and alkaline environments as well as mechanical shocks. So superhydrophobic coatings with self-healing performance have potential applications for the development of durable surfaces.

Two-photon polymerized wetting morphologies for tunable external and internal electrode micropatterning

Numerous existing and emerging microsize technologies operate by utilizing electrical circuits on surfaces and within solid objects, i.e., external and internal electrodes, respectively. While current micropatterning techniques have achieved extensive progress on current systems via pattern resolution and discretization on simple surfaces, the introduction of new applications relies on the complexity of the parts on which these patterns are fabricated. Additionally, many state-of-the-art applications utilize novel materials for functional systems, which further complicates their fabrication. This paper introduces innovative electrode micropatterning and microchannel filling approaches that support complex 3D designs and reduce the number of fabrication steps. The approaches leverage microsize hydrophobic and hydrophilic morphologies fabricated using the two-photon polymerization (2PP) additive manufacturing (AM) process, in conjunction with the target part. Once fabricated, the part is dipped into a conductive solution or other functional liquids, forming patterns on the surfaces and filling the channels based on the pre-designed wetting morphologies. These morphologies incorporate additional structures beyond the conventional hydrophilic and reentrant hydrophobic structures to facilitate the dipping process. This paper demonstrates the efficacy of the tunable electrode micropatterning approach to fabricate various microsystems utilizing 2PP, wetting morphologies, and the developed dipping process.

A Trifunctional Electrolyte Enables Aqueous Zinc Ion Batteries with Long Cycling Performance

AbstractAqueous zinc ion batteries hold promise as alternative systems to lithium‐based batteries. However, practical development faces critical challenges due to parasitic side reactions and dendrite growth in zinc anodes. While introducing electrolyte additives is promising, monofunctional additives offer limited protection to the zinc anode from a single aspect. Herein, a disodium succinate additive is presented to establish a hydrophobic and zincophilic dual electric layer structure on the Zn surface, regulate the solvation structure of Zn2+, and act as a pH buffer during cycling. As a result, the symmetrical cell with an electrolyte containing 0.2 m SADS shows a durable life of over 2200 h, and the Zn||MnO2 full cell still maintains an 80% capacity retention after 1000 cycles. In addition, SADS both show wide applicability in the match with NVO and I2 cathode. This work provides a low‐cost and multifunctional electrolyte additive, facilitating the development of high‐performance aqueous zinc ion batteries.