Hydrolysis Precipitation Method Research Articles

Hollow mesoporous calcium peroxide nanoparticles for drug-free tumor calcicoptosis therapy

Calcium ions (Ca2+) participate in the regulation of cellular apoptosis as a second messenger. Calcium overload, which refers to the abnormal elevation of intracellular Ca2+ concentration, is a factor that can lead to cell death. Here, based on the unique biological effects of Ca2+, hollow mesoporous calcium peroxide nanoparticles (HMCPN) were developed by a facile hydrolysis-precipitation method for drug-free tumor calcicoptosis therapy. The average pore size of the optimized HMCPN17 is 6.4 nm, and the surface area is 81.3 m2/g, which enables HMCPN17 with high drug loading capability. The Ca2+ release from HMCPN17 is much faster at pH 6.8 than that at pH 7.4, which can be ascribed to the acid-triggered conversion of HMCPN17 to Ca2+ and H2O2, indicating a pH-responsive decomposition behavior of HMCPN17. The high drug loading contents of doxorubicin (DOX) and/or sorafenib (SFN) indicate that HMCPN17 can be employed as a generic drug delivery system (DDS). The in vitro and in vivo results reinforce the high calcicoptosis therapeutic efficacy of tumors by our HMCPN17 without drug loading, which can be attributed to the efficient accumulation in tumors and the ability of H2O2 and Ca2+ production at acidic TME. Our HMCPN17 has broad application prospect for construction of multi-drug-loaded composite nanomaterials with diversified functions for the treatment of tumors. Statement of significanceThe combination of hollow mesoporous nanomaterials and calcium peroxide nanoparticles has a wide range of applications in the synergistic treatment of tumors. In this study, hollow mesoporous calcium peroxide nanoparticles (HMCPN) were developed based on a simple hydrolysis-precipitation method for tumor calcicoptosis therapy without drug loading. The high drug loading contents of DOX and/or SFN indicate that our HMCPN can serve as a generic DDS. The experimental results demonstrated the high calcicoptosis therapeutic efficacy of HMCPN on tumors even without drug loading.

Rapid Hydrolysis Precipitation of BiOBr Nanosheets for Boosting Photocatalytic N2 Fixation

AbstractIn this paper, BiOBr nanosheets were synthesized through a novel hydrolysis precipitation method, which significantly reduced energy consumption and time cost compared to traditional hydrothermal synthesis methods. The subjected hydrothermal and high‐temperature calcination process promote the generation of surface oxygen vacancies, which inhibited the recombination of photogenerated electron hole pairs and improve the photocatalytic performance of BiOBr. Additionally, by adjusting the addition amount of KOH in the synthesis process, BiOBr can grow towards more complex crystal structure, which also provides a new path for the fabrication of 2D materials.

Hydrolysis Precipitation Method for the Preparation of Cu‐ZnO@Al2O3 Catalyst in Methanol Steam Reforming

AbstractA hydrolysis precipitation method was developed to prepare Cu based catalyst for methanol steam reforming. A comparison of the hydrolysis precipitation and the conventional coprecipitation method was conducted. The test results present that Cu‐ZnO@Al2O3 prepared by hydrolysis precipitation exhibits better catalytic activity and stability in MSR reaction. XRD, XRF, EDS, SEM, TPR, XPS and N2 adsorption/desorption reveal that the high catalytic performance of Cu based catalyst from hydrolysis precipitation could be attributed to developed pore organization, surface enrichment of active components and higher reducibility.

Solvent extraction and recovery of beryllium from hydrochloric acid solution with naphthenic acid

Beryllium is an essential metal for strategic purposes but remains an under-explored element. The separation of beryllium and aluminium and the purification of beryllium hydroxide from a multi-component solution has always been a challenging task in the beryllium industry and offers great research potential in academic fields. In this research, a solvent extraction method was used to purify and recover beryllium from trace impurities. A systematic investigation of the extraction process revealed that under optimal conditions, 98.66% of the beryllium was extracted in a three-stage countercurrent extraction using naphthenic acid (NA) as the extractant. The aluminium, iron and other trace impurities in the organic phase can be scrubbed with 1 mol/L HCl, then 99.27% of the beryllium was stripped with 5 mol/L NaOH by two-stage stripping. Be(OH)2 with a purity of 99.67% was recovered from the stripped beryllium solution by hydrolysis precipitation method. Furthermore, FT-IR analysis and slope analysis demonstrate the mechanism of beryllium extraction with naphthenic acid accompanied by cation exchange. The influence of temperature on the beryllium extraction was investigated and the thermodynamic parameters and the equilibrium constant of the extraction reaction were calculated. Accordingly, a process flowsheet for the separation of beryllium from multiple impurities using naphthenic acid was developed. This process is believed to offer the advantages of high efficiency, recyclability, and a favorable beryllium-aluminium separation effect; presenting a promising new approach to beryllium recovery.

Enhancing soft magnetic properties of FeSiBNbCu nanocrystalline powder cores by coating ZrO2 insulation layer

The insulation coating plays a crucial role in minimizing core loss (Pcv) in soft magnetic powder cores (SMPCs). In this work, we prepared ZrO2 coating layer on FeSiBNbCu spherical powder by the hydrolysis-precipitation method and investigated the magnetic properties of the FeSiBNbCu@ZrO2 nanocrystalline SMPCs. ZrO2 coating layer were successfully fabricated on the powder by adding a proper amount of K2ZrF6 in alkaline ethyl alcohol solution. The micromorphology and chemical structure of the ZrO2 coating layer on the surface of FeSiBNbCu nanocrystalline powder, as well as the conversion mechanisms, has been investigated. The presence of the ZrO2 coating reduces the Pcv by significantly lowers eddy loss (Pe) of the nanocrystalline SMPCs, meanwhile improves DC bias performance and slightly decreases their permeability. When the additive amount of K2ZrF6 is 1.0 wt%, the nanocrystalline SMPCs has best comprehensive soft magnetic properties, including stable effective permeability (μe) of 57.8 up to 1 MHz, excellent DC bias performance of 59.3 % at a bias field of 100 Oe, and the lowest Pcv of 194.7 mW/cm3 at a frequency (f) of 150 kHz and maximum magnetic induction (Bm) of 50 mT.

Catalytic direct dehydrogenation of ethyl lactate to produce ethyl pyruvate over a synergetic Cu0/Cu+ interface

The direct dehydrogenation of ethyl lactate (EL) to produce ethyl pyruvate (EP) over non-precious heterogeneous catalysts is highly desirable, but challenging. Herein, we report a highly efficient silica-supported copper catalyst prepared via a hydrolysis-precipitation method (Cu/SiO2-HP) for the dehydrogenation of ethyl lactate, which exhibited an 85.4 % EL conversion with 91.1 % selectivity toward EP at 320 °C. XAFS, in situ XPS, and CO-adsorption FT-IR spectra revealed that the Cu/SiO2-HP catalyst had abundant Cu0/Cu+ interfaces. In situ FT-IR spectra, kinetic studies, and theoretical calculations also demonstrated that the Cu0/Cu+ interfaces synergistically activate the O−H and C−H bonds in the adsorbed EL for direct dehydrogenation into EP. The H/D kinetic isotope effect for model reaction confirmed that C−H bond activation is the key step in the dehydrogenation reaction. This study offers a new approach toward the selective conversion of EL into EP, which is of great significance for biomass conversion.

Catalytic properties of LaNiO3 and Mn-modified LaNiO3 catalysts for oxidation of CO and benzene

ABO3-type perovskite oxides containing transition metals at the B site are effective catalysts for oxidation reactions. In this study, LaNiO3 was prepared by the hydrolysis-precipitation method, and LaNiO3 was modified with Mn by the impregnation method. LaNiO3 showed higher CO oxidation activity than LaCoO3, LaMnO3, and LaFeO3. The high activity of LaNiO3 was attributed to the reactivity of the lattice oxygen in LaNiO3, as confirmed by temperature-programmed reduction by H2 (H2-TPR) and CO-TPR studies. The Mn-modified LaNiO3 exhibited higher activity for benzene oxidation than LaNiO3. The CO oxidation properties of the Mn-modified LaNiO3 catalysts correlated with their H2-reduction properties, whereas benzene oxidation properties were improved by the increasing amount of Mn on the catalyst surface.

Impact of oxygen-calcium-generating and bone morphogenetic protein-2 nanoparticles on survival and differentiation of bone marrow-derived mesenchymal stem cells in the 3D bio-printed scaffold

Although stem cell therapy is a major area of interest in tissue engineering, providing proper oxygen tension, good viability, and cell differentiation remain challenges in tissue-engineered scaffolds. In this study, an osteogenic scaffold was fabricated using the 3D bio-printing technique. The bio-ink contained alginate hydrogel, encapsulated human bone marrow-derived mesenchymal stem cells (hBM-MSCs), calcium peroxide nanoparticles (CPO NPs) as an oxygen generating biomaterial, and bone morphogenic protein-2 nanoparticles (BMP2 NPs) as an osteoinductive growth factor. CPO NPs were synthesized with the hydrolysis–precipitation method, and their concentrations in the bio-ink were optimized. Scaffolds containing CPO 3% (w/w) were preferred, because they generated sufficient oxygen gas for 20 days, increased mechanical strength after 20 days, and had sufficient stability. The CPO NPs effect on the viability of embedded hBM-MSCs under hypoxic conditions was analyzed. Live/Dead staining results represented a 22% improvement in CPO 3% scaffold viability on day 7. Therefore, CPO NPs constituted a promising survival factor. BMP2 NPs were prepared with the double emulsification technique. The incorporation of both BMP2 and CPO NPs resulted in the upregulation of Runt-related transcription factor 2, Collagen type I alpha 1, and the osteocalcin genes compared to internal references in osteogenic media. Overall, the proposed 3D bio-printed osteogenic scaffold in this study has moved scientific research one step forward toward successful stem cell therapy and helped improve host tissue healing by biological activity enhancement, especially for low oxygen pressure tissues.

N-TiO2-Coated SiC Foam for the Treatment of Dyeing Wastewater under Blue Light LED Irradiation

TiO2 is widely used for the photocatalytic degradation of organic pollutants in wastewater, but the practical applications of the photocatalyst are limited due to its poor visible light absorption and low recovery rate. In this study, high production of nitrogen-doped TiO2 was achieved by a hydrolysis precipitation method; the obtained N-TiO2 had a small crystallite size and good dispersibility. The effect of calcining temperature on the photocatalytic performance of N-TiO2 was evaluated through the degradation of methylene blue (MB) in a blue light LED irradiation cylinder, it was found the N-TiO2 calcined at 400 °C showed the best photocatalytic activity. Then the N-TiO2 was immobilized on SiC ceramic foam by dip-coating with PVA as the binder. The prepared N-TiO2/SiC foam showed excellent photocatalytic activity under blue light LED irradiation; as high as 96.3% of MB was degraded at optimum conditions. After five cycles of MB photodegradation, the photocatalytic activity of N-TiO2/SiC foam only changed slightly, which makes it a promising photocatalytic material for wastewater treatment.

Biological renewable nanocellulose templated CeO2/TiO2 synthesis and its photocatalytic removal efficiency of pollutants

The CeO2/TiO2 templated with nanocellulose was prepared through hydrolysis–precipitation method. The nanocellulose templated CeO2/TiO2 catalyst abbreviated as CeO2/TiO2-NCC was characterization by XPS, XRD, UV–Vis DRS, FTIR, SEM, TEM and N2 adsorption/desorption methods. The CeO2/TiO2-NCC photocatalytic efficiency was also checked for the removal of Rhodamine B (RhB), methyl orange (MO), and reduction of Cr(VI). As it is indicated from the results, the CeO2/TiO2-NCC prepared with nanocellulose as a template showed greater performance than CeO2/TiO2 prepared without nanocellulose templated. Complete removal of MO and RhB, (250 mL, 50 ppm), and reduction of Cr(VI) solution (250 mL, 50 ppm) were achieved within 70, 50, and 60 min, respectively. Therefore, the CeO2/TiO2-NCC exhibited enhanced photocatalytic activity due to smaller crystallite size, greater specific surface area, and lower electron and hole recombination rate.

Preparation of TiO2/cellulose nanocomposites as antibacterial bio-adsorbents for effective phosphate removal from aqueous medium

The design of environmentally benign bio-adsorbents for the removal of phosphate from aqueous medium was an economic and effective way for controlling eutrophication. Herein, we prepared three kinds of TiO2/cellulose (CE-Ti) nanocomposites by a facile hydrolysis-precipitation method, and used them as antibacterial bio-adsorbents for the removal of phosphate from aqueous medium. Multiple techniques including Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) and thermogravimetric analysis (TGA) were employed to characterize the nanostructure and characteristics of the prepared CE-Ti nanocomposite. The adsorption capacity of the CE-Ti was 19.57 mg P g−1 according to the Langmuir model, which was 6 times higher than that of CE. Importantly, the bacterial inhibition zone of the CE-Ti was 2.88 mm (that of CE was 0 mm), indicating that CE-Ti had good antibacterial activity that could reduce the attachment of the microorganism to the surface of CE-Ti, which was suitable for long-term phosphate removal. Moreover, the CE-Ti had good adsorption selectivity and anti-interference capability, according to interfering ions and ion strength experiments. Furthermore, Ti4+ leakage tests suggested that CE-Ti was highly stable under acidic, neutral and alkali conditions. These results indicated that the CE-Ti nanocomposite could be utilized as a promising antibacterial bio-adsorbent for effective phosphate removal from aqueous medium.

Efficient and selective oxidation of cyclohexane to cyclohexanone over flake hexagonal boron nitride/titanium dioxide hybrid photocatalysts

• A flake h -BN/TiO 2 hybrid photocatalyst was successfully synthesized by hydrolysis-precipitation method. • h -BN/TiO 2 photocatalyst exhibited enhanced photocatalytic activity and selectivity. • A desired efficient and selective oxidation of CHA to CHA-one was achieved. • Possible mechanism for enhancing photocatalytic performance was proposed. Selective oxidation of cyclohexane (CHA) with oxygen (O 2 ) to product cyclohexanone (CHA-one) is an important reaction for the modern chemical industry. The present work constructs a flake hexagonal boron nitride/titanium dioxide ( h -BN/TiO 2 ) hybrid photocatalyst to achieve a desired selective and efficient oxidation of CHA to form CHA-one with a mild and green condition under atmospheric pressure, at room temperature, and in solvent-free. The activity of 14 wt% h -BN/TiO 2 composite is significantly enhanced to about four times as compared with that of bare TiO 2 . Moreover, the CHA-one selectivity of 14 wt% h -BN/TiO 2 composite (>85%) is much higher than that of pure TiO 2 (approximately 60%). Additionally, h -BN/TiO 2 composites can also display superior cycling stability and recoverability. The reasons for the promoted photocatalytic performance of h -BN/TiO 2 were revealed by the photo-electrochemical experiments and DFT calculations. Both the negatively charged h -BN and its flake structure can effectively enhance valence band holes transfer from the inside of TiO 2 to h -BN surface, and further improve the separation of photoformed hole-electron pairs to promote photocatalytic performance. The present approach will contribute to the build of more efficient photo-oxidation systems and to the construction of advanced composite photocatalysts for selective oxidation.

Interface engineering of earth-abundant Cu/In(OH)3 catalysts towards electrochemical reduction of CO2 favoring CO selectivity

Interface engineering has been an alternative strategy applied to catalysts, which is desirable for CO2 electrochemical reduction reaction (ECO2RR) to obtain high selectivity for specific products. Herein, we report Cu/In(OH)3 heterogeneous structure catalyst attached on mildly oxidized carbon nanotubes (CNTs) originating from CuO/In(OH)3 via a facile wet hydrolysis precipitation method for ECO2RR. The selectivity of CO can be tuned by slightly adjusting the In/(Cu + In) (YIn) atomic fraction. Typically, high Faradaic efficiency (FE) of CO (89%) with the partial current density of 10.1 mA/cm2 at –1.0 V(versus a reversible hydrogen electrode, RHE) is obtained at YIn = 4.5%, outperforming the most reported Cu-In based catalysts. The strong interaction between Cu and In(OH)3 are responsible to promote FECO. Designing the metal/metal hydroxide electrocatalysts for electrochemical CO2 reduction reaction opens an alternative opportunity for optimizing efficient and selective catalysts for desired products.

Adsorption and photocatalytic activity of Cu-doped cellulose nanofibers/nano-titanium dioxide for different types of dyes.

Cu-doped cellulose nanofibers/nano-titanium dioxide (Cu-TOCN/TiO2) photocatalysts were prepared by the hydrolysis-precipitation method using TiCl4 as the source of titanium and cellulose nanofibers suspension as a reaction medium. The prepared photocatalysts were used to decolorize organic dyes (reactive brilliant red K-2BP and cationic red X-GRL) efficiently under the synergistic effect of simultaneous adsorption and photocatalysis. The combination of TOCN inhibited the growth of TiO2 crystals, reduced agglomeration and increased the specific surface area. When compared with TiO2, TOCN/TiO2 improved the decolorization efficiency of the two dyes by 14.82% and 22.87%, respectively, under UV-light irradiation. The absorption edge exhibited red-shift from 380 to 410 nm after Cu doping. An excellent photocatalytic activity was recorded by 0.5 mol % Cu-TOCN/TiO2 and the decolorization efficiency of the two dyes was further improved by 34.76% and 10.44% respectively, compared with no Cu doping. After 2 hours of irradiation, the decolorization efficiency reached 96.57% and 99.73% respectively, while under dark conditions, it was 47.64% and 91.56% for the two dyes. The degradation mechanism of the dyes was verified as the destruction of the azo chromophore and benzene ring. This work provides a potential method for the development of a novel adsorptive photocatalyst with excellent recyclability.

Separation of Aluminum and Iron from Lanthanum—A Comparative Study of Solvent Extraction and Hydrolysis-Precipitation

This study investigates the removal of aluminum and iron from rare earth element (REE) containing solutions by solvent extraction with saponified naphthenic acid and by hydrolysis-precipitation. The results emphasize both, the preferential application as well as limitations of every method. We find that emulsification occurring during the solvent extraction of aluminum is caused by its slow extraction rate in comparison to the neutralization reaction and by the proximity of the pH value required for aluminum extraction and the pH value at which hydrolysis of aluminum occurs. However, by choosing a long shaking time of at least 4 h, the emulsion recedes. The formation of emulsion can be avoided by strict control of pH value during the extraction. Moreover, the loading capacity of the organic phase with aluminum is limited due to the strong increase in viscosity of the organic phase with increasing aluminum concentration and due to the gel formation. Regarding the extraction of iron, the amount of extracted ions is limited due to the overlap of the pH range required for the extraction with pH range in which sparingly soluble iron oxides/hydroxides are formed. In summary, aluminum and iron can be simultaneously removed from REE-sulfate solution by solvent extraction with saponified naphthenic acid in one extraction stage only from diluted solutions. However, in comparison to the hydrolysis-precipitation method, a higher purity of the solution is achieved. A complete removal of aluminum and iron from concentrated solutions can be achieved in two stages. First, the content of aluminum and iron should be reduced by hydrolysis-precipitation. After that, a high-purity solution can be obtained by subsequent solvent extraction by saponified naphthenic acid.

Enhanced visible light activity of EuFeO3/TiO2 nanocomposites prepared by thermal treatment–hydrolysis precipitation method

The present paper aimed to, through combination of TiO2 and a rare earth ferrite and EuFeO3 nanoparticles, synthesize a new visible light active photocatalyst. The EuFeO3/TiO2 nanocomposites were synthesized by a thermal treatment approach, in combination with a hydrolysis precipitation processing. The influences of concentration of TiO2 nanoparticles on morphological, magnetic and structural properties of EuFeO3/TiO2 nanocomposites were examined by different characterization techniques. Moreover, the optical characteristic of the synthesized samples was evaluated by UV–visible diffuse reflectance spectrophotometry. The nanocomposites’ photocatalytic activity was also assessed under the visible light (λ > 400 nm), considering Congo red molecules degradation. Considerable degradation efficiency was observed (68% after 30 min), especially after using EuFeO3/TiO2 nanocomposites ratio of 1:0.5. The performed analysis revealed that EuFeO3/TiO2 (1:0.5) nanocomposite could be structured in a way that led to a considerable redshift in the onset of light absorption in comparison with that of pure TiO2. The constructed EuFeO3–TiO2 heterojunction caused a considerable increase in the photocatalytic degradation of the target pollutant, as a result of occurred diminished in electron–hole recombination.

The Role of the Aluminum Source on the Physicochemical Properties of γ-AlOOH Nanoparticles

The effect on the physicochemical properties of aluminum salts on the synthesis of γ-AlOOH nanostructures has been investigated in detail using a hydrolysis-precipitation method. X-ray fluorescence (XRF), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM), were used to characterize the synthesized samples. The specific surface area, pore size distribution and pore diameter of the different γ-AlOOH structures were discussed by the N2 adsorption-desorption analysis. According to the results of the nanostructure, characterization revealed that for synthesized γ-AlOOH nanostructures from AlCl3 and Al(NO3)3, obvious XRD peaks corresponding to the bayerite phase are found indicating an impure γ-AlOOH phase. Furthermore, the nitrogen adsorption-desorption analysis indicated that the obtained γ-AlOOH nanoparticles from Al2(SO4)3 of technical grade (95.0 % of purity) and low cost, possess a high BET surface area of approximately 350 m2/g, compared to the obtained nanostructures from aluminum sources reactive grade, which was attributed to the presence of Mg (0.9 wt.%) in its nanostructure.

Cu/Al2O3 catalyst prepared by a double hydrolysis method for a green, continuous and controlled N-methylation reaction of nitroarenes with methanol

Cu/Al2O3 catalyst was developed by a double hydrolysis precipitation. Over the Cu/Al2O3 catalyst, a continuous mode of N-methylations of nitroarenes with methanol was successfully achieved under the exogenous base- and H2- free condition. Methylation process of nitroarenes could be controlled just by adjusting reaction conditions, affording the desired N-monomethylanilines or N, N-dimethylanilines, respectively. The characterization displayed that the double hydrolysis precipitation method made active metal Cu surface enrichment and high dispersion, meanwhile endow Cu/Al2O3 with more developed pore system, which were responsible for the higher performance of our catalyst relative to Cu/Al2O3-CP. Compared with the reported batch mode, our procedure possessed the merits of low cost, environment-friendliness, better controllability and wide universality.

Interface tuning of Cu+/Cu0 by zirconia for dimethyl oxalate hydrogenation to ethylene glycol over Cu/SiO2 catalyst

An efficient ZrO2–doped Cu/SiO2 catalyst was fabricated through hydrolysis precipitation method (HP) and used to produce ethylene glycol (EG) through dimethyl oxalate (DMO) hydrogenation. The states for zirconia on copper catalyst and roles in DMO hydrogenation were investigated through various characterization tools, including N2 physical adsorption, XRD, H2–TPR, Methyl glycolate–TPD–MS, XPS, XAES as well. Compared with common ammonia evaporation and co–precipitation methods used in catalyst preparation, this HP method is found to effectively suppress the agglomeration and further size growth of copper nanoparticles by enhancing the interactions between copper and zirconia species. More importantly, uniform distribution of ZrO2 dopant is achieved due to the pseudo-homogeneous reactions in the mixing step of catalyst preparation. A proper amount of zirconium dopant helps achieve the desirable proportion of Cu+/(Cu++Cu0) for surface copper species, especially promotes the production of Cu+ species originated from Cu–ZrO2 species at the interface of copper and zirconia particles. In comparison with Cu+ species formed from copper phyllosilicates reduction, the Cu+ sites derived from Cu–ZrO2 species show higher adsorption ability of MG, an important intermediate species in ethylene glycol production. These adsorbed MG molecules further react with atomic hydrogen shifted from adjacent metallic copper surface, leading to a higher catalytic behavior. For the EG production via DMO hydrogenation, the turnover frequency (TOF) normalized by Cu0 species on CuZr/SiO2 catalyst is 1.8 times than that of traditional Cu/SiO2 counterpart. Due to the enhanced synergy effect between Cu+ and Cu0 active sites, a lower activation energy of ester hydrogenation on this ZrO2–doped Cu/SiO2 catalyst is believed to be responsible for the significant improvement.

Highly active Ce, Y, La-modified Cu/SiO2 catalysts for hydrogenation of methyl acetate to ethanol.

Rare earth element (Ce, Y, and La) modified Cu/SiO2 catalysts via hydrolysis precipitation and impregnation method were fabricated for the vapor-phase hydrogenation of methyl acetate to ethanol. LaOx showed the most pronounced promotion in the catalytic tests. After detailed characterizations, via N2 adsorption–desorption, XRD, N2O chemisorption, FTIR, H2-TPR, H2-TPD, TEM, XPS, and TG/DTA, we found that the addition of promoter LaOx can decrease the particle size while in turn, it can increase the dispersion of copper species. The strong interactions between copper and lanthanum atoms alter the surface chemical states of the copper species. This results in the generation of more Cu+ species and high SCu+ values, which are responsible for the excellent activity and stability during hydrogenation. In addition, the content of additive LaOx and reaction conditions (reaction temperature and LHSV) were optimized. Then, the long-term stability performance was evaluated over the selected catalyst in contrast with Cu/SiO2.