Study regionPrahova river basin located in the central-southern region of Romania. Study focusThis study aims to assess the susceptibility to flooding by using state-of-the-art machine learning and optimization procedures. To achieve this goal, we employed ten flood-related variables as independent variables in our machine learning models. These variables include slope angle, convergence index, distance from the river, elevation, plan curvature, hydrological soil group, lithology, topographic wetness index, rainfall, and land use. We used 158 flood locations as dependent variables in the training of four hybrid models: Deep Learning Neural Network-Statistical Index (DLNN-SI), Particle Swarm Optimization-Deep Learning Neural Network-Statistical Index (PSO-DLNN-SI), Support Vector Machine-Statistical Index (SVM-SI), and Particle Swarm Optimization-Support Vector Machine-Statistical Index (PSO-SVM-SI). Utilizing the Statistical Index method, we calculated coefficients for each flood predictor class or category. New hydrological insights for the regionThe PSO-DLNN-SI model demonstrated the best performance, achieving an AUC-ROC curve of 0.952. It's worth noting that the application of the PSO algorithm significantly enhanced the model's performance. Additionally, it's crucial to highlight that approximately 25 % of the study region exhibits a high to very high susceptibility to flood events. Taking into account the very precise results of the models applied in the present study, we can state that from a hydrological point of view, the current research contributes to a better understanding of the intensity with which floods can affect the different areas of the Prahova river basin.