Metal-organic frameworks (MOFs) is easy to agglomerate at high temperature, resulting in the rapid collapse of the MOFs structure and the aggregation of metal sites. In this paper, Al2O3 is used as the support material to support the in-situ synthesis of Ni-MOF on the surface, and the metal Ni nanoparticles are successfully fixed on the Al2O3. The results showed that both Ni/Ni-MOF-300 and Ni/NA-MOF-300 catalysts reduced at 300 ℃ have good hydrogenation activity of benzene, and Ni/Ni-MOF-450 catalysts reduced at 450 ℃ formed huge Ni aggregates, which significantly reduced the hydrogenation activity of benzene. However, Ni/NA-MOF-450 catalyst reduced at 450 ℃ can effectively resist the metal Ni agglomeration caused by the collapse of MOFs structure at high temperature, and has better hydrogenation activity of benzene.