Hydrogen Sulfide Gas Research Articles

A potent nano-strategy for dual energy deprivation to inhibit pancreatic cancer progression

Pancreatic cancer is a highly malignant tumor that poses significant threats to public health, and glycolysis plays a crucial role in its energy metabolism. Here, glycolysis was confirmed to be directly associated with poor prognosis through the use of clinical samples from 130 patients with pancreatic ductal adenocarcinoma (PDAC), and the effectiveness of zinc ions (Zn2+) in inhibiting glycolysis-related genes was further validated. Therefore, polyvinyl pyrrolidone (PVP)-modified zinc sulfide nanomedicines (ZnS-PVP) were developed for dual energy suppression by targeting glycolysis and mitochondrial respiration in pancreatic cancer. On the one hand, the released Zn2+ efficiently inhibited glycolysis in pancreatic cancer cells through the PI3K-Akt-mTOR-HIF-1α signaling axis. On the other hand, acid-responsive release of hydrogen sulfide (H2S) gas damaged mitochondria and further reduced energy compensation by inhibiting oxidative phosphorylation. This two-pronged energy deprivation nano-strategy effectively eliminated pancreatic cancer cells and was proven to overcome chemotherapeutic resistance. Moreover, ZnS-PVP administration combined with immune checkpoint blockade (ICB) therapy significantly suppressed tumor progression in mouse orthotopic pancreatic tumor models, as also demonstrated in a pancreatic cancer patient-derived xenograft (PDX) model. Our work highlights the positive role of bioactive metal ions in targeting tumor energy metabolism and the great potential of nano-strategy for energy deprivation in the treatment of pancreatic cancer.

Chemoresistive H2S sensor based on PANI/TiO2/CuCl2 nanocomposite impregnated conductive fabric using TOPSIS and Taguchi method

Abstract Conductive polymer/metal oxide nanocomposites have been widely used for chmoresistive gas sensors. PANI/TiO2/CuCl2 nanocomposite(PTCN) impregnated conductive fabric was prepared by in-situ synthesis method. To improve the performance of PTCN impregnated fabric for detecting H2S gas, Taguchi orthogonal array(TOA) is used to experimental design, and best values of factors affecting to the sensing performance are determined using Technique for order preference by similarity to ideal solution (TOPSIS) and Taguchi optimization method. PTCNs were charactierized by SEM, XRD, FTIR. The sensing performances of the proposed sensor such as linear detection range, sensitivity, repeatability and effect of humidity for hydrogen sulfide gas were evaluated.

Synthesis of MIPs@H2S Nanoparticle Adsorbent for the Specific Adsorption of Hazardous Hydrogen Sulfide Gas: Approach to Optimization

Synthesis of MIPs@H2S Nanoparticle Adsorbent for the Specific Adsorption of Hazardous Hydrogen Sulfide Gas: Approach to Optimization

Evidence for a hydrogen sulfide-sensing E3 ligase in yeast.

In yeast, control of sulfur amino acid metabolism relies upon Met4, a transcription factor that activates the expression of a network of enzymes responsible for the biosynthesis of cysteine and methionine. In times of sulfur abundance, the activity of Met4 is repressed via ubiquitination by the SCFMet30 E3 ubiquitin ligase, but the mechanism by which the F-box protein Met30 senses sulfur status to tune its E3 ligase activity remains unresolved. Herein, we show that Met30 responds to flux through the trans-sulfuration pathway to regulate the MET gene transcriptional program. In particular, Met30 is responsive to the biological gas hydrogen sulfide, which is sufficient to induce ubiquitination of Met4 in vivo. Additionally, we identify important cysteine residues in Met30's WD-40 repeat region that sense the availability of sulfur in the cell. Our findings reveal how SCFMet30 dynamically senses the flow of sulfur metabolites through the trans-sulfuration pathway to regulate the synthesis of these special amino acids.

Degree of Impact of Applying Environmental Cost Accounting on Tax Revenues from Oil Companies Operating in Iraq

Protecting the environment and its natural resources is an issue of great importance at the local and global levels. The phenomenon of environmental pollution resulting from the work of oil companies is one of the dangerous phenomena facing the environment in Iraq in general, and the environment of Kirkuk Governorate in particular, as the latter is considered one of the governorates rich in mineral resources, especially oil, as it contains six oil fields, and it contains the largest oil field in Iraq. Estimates indicate that it produces (40%) of the total Iraqi oil, so it suffers from a significant increase in the proportions of toxic and environmentally polluting gases resulting from the work of these companies in it. The work of oil companies from exploration, extraction and refining oil will naturally result in the emission of many gases that are highly toxic, dangerous and harmful to human health. The most important of these gases are carbon monoxide, sulfur dioxide, nitrogen dioxide, hydrocarbon compounds, hydrogen sulfide and other gases that pollute the environment, which has resulted in the spread and increase in the number of patients with respiratory diseases in a clear and increasing manner in the governorate. This increase in environmental costs falls on society as a whole, so it was necessary to identify and measure environmental costs from the society’s point of view and work to re-charge them to oil companies by applying the environmental tax.

Synergistic Gas Therapy and Targeted Interventional Ablation With Size-Controllable Arsenic Sulfide (As2S3) Nanoparticles for Effective Elimination of Localized Cancer Pain.

The elimination of localized cancer pain remains a globally neglected challenge. A potential solution lies in combining gas therapy with targeted interventional ablation therapy. In this study, HA-As2S3 nanoparticles with controlled sizes are synthesized using different molecular weights of sodium hyaluronate (HA) as a supramolecular scaffold. Initially, HA co-assembles with arsenic ions (As3+) via coordinate bonds, forming HA-As3+ scaffold intermediates. These intermediates, varying in size, then react with sulfur ions to produce size-controlled HA-As2S3 particles. This approach demonstrates that different molecular weights of HA enable precise control over the particle size of arsenic sulfide, offering a straightforward and environmentally friendly method for synthesizing metal sulfide particles. In an acidic environment, HA-As2S3 nanoparticles release hydrogen sulfide(H2S) gas and As3+. The released As3+ directly damage tumor mitochondria, leading to substantial reactive oxygen species (ROS) production from mitochondria. Concurrently, the H2S gas inhibits the activity of catalase (CAT) and complex IV, preventing the beneficial decomposition of ROS and disrupting electron transfer in the mitochondrial respiratory chain. Consequently, it is found that H2S gas significantly enhances the mitochondrial damage induced by arsenic nanodrugs, effectively killing local tumors and ultimately eliminating cancer pain in mice.

Characterization and Ambient Temperature Hydrogen Sulfide Sensing of Annealed NiO-MnO₂ Thin Films Prepared via Jet Nebulizer Spray Pyrolysis

A jet nebulizer spray pyrolysis technique to synthesize NiO-MnO2 thin films was demonstrated. These nanosheets were annealed at 350, 450 and 550 °C for 2 hours. The thin films surface morphology and structure were characterized using scanning electron microscopy, XRD, and UV spectroscopy. Subsequently, utilized as gas sensors for the detection of hydrogen sulphide gas. The introduction of NiO into MnO2 nanosheets significantly improved the gas-sensing performance. Notably, the gas-sensing response of the NiO-MnO2 nanosheet sensor surpassed that of both NiO and MnO2 alone, reaching a notable value of 165 when detecting 100 ppm hydrogen sulfide gas with the NiO-MnO2 thin film sensor. A remarkable feature of the NiO-MnO2 thin film sensor is its accelerated response time, registering at 10 seconds when exposed to 100 ppm of hydrogen sulfide gas. The mechanism underlying gas sensing and the factors contributing to the enhanced gas response of NiO-MnO2 thin film is thoroughly discussed. From a broader perspective, these developed sensors present a novel platform for the identification and monitoring of hydrogen sulfide gas, showcasing significant advancements in gas-sensing technology.

Gastrointestinal Impact of Flatulence-Causing Compounds in Foods: A Scientometric Study

Flatulence, or the passing of gas, can be caused by various factors, including the consumption of foods that contain hydrogen sulfide. When these foods are digested, they can release hydrogen sulfide gas, accumulating in the intestines and releasing flatulence. The present study aimed to give a scientometric overview of publications on flatulence regarding productive sources/journals, top active authors, foremost affiliations, prominent countries, and most used author’s keywords. In all, 4752 articles were downloaded from the Web of Science [WoS] database [2007-2021], consisting of journal articles, review articles, and the English language. Data analysis and network visualization maps were created using Micro Soft Excel, Biblioshiny, and VOS viewer. The results indicate that the most productive author was Germain DP contributed 53 papers with the highest received 4026 citations. The topmost journal contributions were Plos One with number 113. Findings revealed that the top two institutions were from Canada. It was revealed that the United States, and China were the second-ranked in document contributions related to flatulence research. Articles produced by single-country publications had a higher number of papers compared with papers produced by multiple-country publications. Clinical research is a crucial aspect of healthcare as it helps determine the safety and effectiveness of new medical interventions, which can be used to improve patient outcomes related to flatulence research.

Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of H2S.

The kidney is an essential excretory organ that works as a filter of toxins and metabolic by-products of the human body and maintains osmotic pressure throughout life. The kidney undergoes several physiological, morphological, and structural changes with age. As life expectancy in humans increases, cell senescence in renal aging is a growing challenge. Identifying age-related kidney disorders and their cause is one of the contemporary public health challenges. While the structural abnormalities to the extracellular matrix (ECM) occur, in part, due to changes in MMPs, EMMPRIN, and Meprin-A, a variety of epigenetic modifiers, such as DNA methylation, histone alterations, changes in small non-coding RNA, and microRNA (miRNA) expressions are proven to play pivotal roles in renal pathology. An aged kidney is vulnerable to acute injury due to ischemia-reperfusion, toxic medications, altered matrix proteins, systemic hemodynamics, etc., non-coding RNA and miRNAs play an important role in renal homeostasis, and alterations of their expressions can be considered as a good marker for AKI. Other epigenetic changes, such as histone modifications and DNA methylation, are also evident in AKI pathophysiology. The endogenous production of gaseous molecule hydrogen sulfide (H2S) was documented in the early 1980s, but its ameliorative effects, especially on kidney injury, still need further research to understand its molecular mode of action in detail. H2S donors heal fibrotic kidney tissues, attenuate oxidative stress, apoptosis, inflammation, and GFR, and also modulate the renin-angiotensin-aldosterone system (RAAS). In this review, we discuss the complex pathophysiological interplay in AKI and its available treatments along with future perspectives. The basic role of H2S in the kidney has been summarized, and recent references and knowledge gaps are also addressed. Finally, the healing effects of H2S in AKI are described with special emphasis on epigenetic regulation and matrix remodeling.

Identifying sulphurous water discharge from legacy oil and gas wells using spectral band analysis of aerial and satellite imagery

Legacy oil and gas wells are a significant source of hydrogen sulphide and methane gas release to the atmosphere. Unanticipated occurrences of gas release in urbanized areas can pose human health risks. Several high hydrogen sulphide-emitting wells have been identified in Norfolk County, Ontario, Canada, based on the remote detection of sulphurous water discharging to the surface along the wellbore. Although oil and gas well records report well status and location, community reports of noxious hydrogen sulphide odours suggest potentially compromised well seals and inaccuracies in their documented location. Given the broad-scale nature of this issue and limitations in site access, a remote-sensing based methodology utilizing satellite and high-resolution aerial photography could support identification of undocumented sulphurous water leaks associated with compromised oil and gas wells and subsequent characterization of hydrological and ecohydrological impacts over time. This study presents a multifaceted approach to identifying sulphurous leaking wells utilizing complimentary remote sensing imagery and image analysis tools within ArcGIS. Southwestern Ontario Orthophotography Project air photos and Sentinel-2 satellite imagery were determined to be the most applicable sources of imagery based on their respective advantages in resolution and revisit time. The application of a normalized difference vegetation index showed that major well leaks could exhibit signs of vegetative scarcity, while minor well leaks may have only a limited impact on vegetation. A band combination utilizing the green and near infrared bands was created to enhance the detection of sulphurous water leaks. Utilizing the identified band combination, a pair of potentially undiscovered leaks were located west of a fluvial river channel. Continued research should attempt to employ an automated approach for discerning additional sulphurous water leaks in the region or at different points in time. Possible techniques may involve the deep learning object and change detection models incorporated in ArcGIS.

Research and Prevention of Harmful Gases in Special Structures of Urban Deep Drainage Systems

Wastewater remaining in pipes for extended periods can create anaerobic environments, fostering the growth of anaerobic bacteria and producing harmful gases such as methane and hydrogen sulfide. Additionally, certain structures within drainage systems, such as drop shafts and vertical shafts, induce turbulent flow, causing the release of dissolved harmful gases, which pose significant risks to public health and urban infrastructure. This study focused on the investigation and analysis of vertical shafts with helical tray structures in drainage systems. Using ANSYS 2021 R2 software, simulations of the shafts were conducted by employing the standard k-ε turbulence model and Eulerian multiphase flow method to simulate the shaft’s operation and obtain various parameters of hydrogen sulfide release. Concurrently, a scale model constructed in the laboratory was used to study and analyze the release of hydrogen sulfide gas dissolved in water from this type of structure. Combining the simulation and laboratory experiments, the hydrogen sulfide gas release rate from water in this structure was 0.05–0.4%. This research provides a reference for the study and control of hydrogen sulfide gas release.

Study on the changes and transformation characteristics of intermediate liquid products in hydrogen sulfide production from lignite degraded by sulfate-reducing bacteria.

The changes and transformation laws of intermediate liquid-phase products during the anaerobic degradation of lignite by sulfate-reducing bacteria in the formation of hydrogen sulfide play an important role in supplementing and improving the existing theories on the genesis of hydrogen sulfide gas in coal mines. In this paper, H2S gas and key intermediate liquid-phase products produced during the anaerobic degradation of lignite by sulfate-reducing bacteria were detected and analyzed by gas chromatography and gas chromatography-mass spectrometry. The results showed that the process of hydrogen sulfide production from lignite degradation by sulfate-reducing bacteria can be roughly divided into four stages: slow production phase, rapid growth phase, steady production phase, and slight decline phase. In this reaction system, the SO42- concentration showed a decreasing trend, the pH value showed an increasing trend, and the ORP value decreased and then slightly increased with time. Ten volatile component types were detected during the experiment: straight-chain alkanes, branched-chain alkanes, alcohols, aldehydes, ketones, olefins, amines, lipids, acids and phenols. The key components in the intermediate liquid phase products were straight chain alkanes, straight chain alkanes, acids, alcohols, phenols and amines. PAHs, alkanes, and phenols are closely related to H2S production, while amides stimulate nitrogen production. The process is divided into three stages: hydrolysis stage, H2S gas production stage, and decay stage. Liquid-phase intermediates play an important role in the formation process of coal mine BSR hydrogen sulfide and the mechanism of coal mine H2S genesis.

High-sensitive and fast-responsive In2O3 thin film sensors for dual detection of NO2 and H2S gases at room temperature

In this work, the room-temperature dual gas sensing characteristics of indium oxide (In2O3) thin films towards NO2 and H2S have been studied. In2O3 thin films were synthesized by the thermal oxidation of indium metal films of various thicknesses in the range of 50–250 nm deposited by thermal evaporation method. Grazing incidence X-ray diffraction (GI-XRD) revealed the change in preferred orientation of In2O3 thin films corresponding to varying thickness, while field-emission electron microscopy studies showcased evolving surface morphologies from individual grains to granular network with respect to the increase in film thickness. Investigations were made on the ability of In2O3 thin films to detect various low concentrations of nitrogen dioxide (NO2) and hydrogen sulfide (H2S) gases at ambient temperature. In2O3 thin films synthesized using 100 nm thick In films exhibited good sensing response of around 58 and 68 % towards NO2 and H2S gases of 5 ppm respectively, at room temperature (27 °C) with the response time of 36 and 18 s. Remarkably, the lower experimental detection limit of these toxic gases could be extended up to 100 ppb. Using X-ray photoelectron spectroscopy, a large presence of surface oxygen is observed on the In2O3 thin film. The sensor has demonstrated remarkable sensing abilities, including strong selectivity, quick sensing response, and good repeatability.

Persulfide Dioxygenase from Pseudomonas aeruginosa unveils a novel crosstalk mechanism between the bioenergetically-relevant gaseous signaling molecules nitric oxide and hydrogen sulfide

Persulfide Dioxygenase from Pseudomonas aeruginosa unveils a novel crosstalk mechanism between the bioenergetically-relevant gaseous signaling molecules nitric oxide and hydrogen sulfide

Is Farming a Risk Occupation for Cardio-cerebrovascular Diseases? A Scoping Review on Cardio-cerebrovascular Disease Risk in Farmers.

In the Republic of Korea, cardiocerebrovascular disease (CCVD) is recognized as an occupational disease when sufficient evidence of a work-related burden exists. In 2021, approximately 26.8% of the payments from occupational disease insurance under the Industrial Accident Compensation Insurance Act were allocated to CCVDs. However, due to the specific nature of insurance policies for farmers, CCVD is not acknowledged as an occupational disease in their case. We reviewed studies on the differences in the incidence, prevalence, and mortality rates of CCVDs between farmers and the general population or other occupations and described the exposure of farmers to risk factors for CCVDs. Several studies showed that farming is a high-risk occupation for CCVDs, with the following risk factors: long working hours, night work, lack of holidays, and strenuous physical labor; physical factors (noise, cold, heat, humidity, and vibration); exposure to hazardous gases (diesel exhaust, carbon monoxide, hydrogen sulfide, carbon disulfide, nitrogen oxides, and polycyclic aromatic hydrocarbons), pesticides, and dust (particulate matter, silica, and organic dust); exposure to a hypoxic environment; and job-related stress. Social isolation and lack of accessible medical facilities also function as additional risk factors by preventing farmers from receiving early interventions. Farmers are exposed to various risk factors for CCVDs and are an occupation at risk for CCVDs. More studies are needed in the future to elucidate this relationship. This study lays the groundwork for future research to develop guidelines for approving CCVDs as occupational diseases among farmers.

A Two-Pronged Nanostrategy of Iron Metabolism Disruption to Synergize Tumor Therapy by Triggering the Paraptosis-Apoptosis Hybrid Pathway.

Iron metabolism has emerged as a promising target for cancer therapy; however, the innate metabolic compensatory capacity of cancer cells significantly limits the effectiveness of iron metabolism therapy. Herein, bioactive gallium sulfide nanodots (GaSx), with dual functions of "reprogramming" and "interfering" iron metabolic pathways, were successfully developed for tumor iron metabolism therapy. The constructed GaSx nanodots ingeniously harness hydrogen sulfide (H2S) gas, which is released in response to the tumor microenvironment, to reprogram the inherent transferrin receptor 1 (TfR1)-ferroportin 1 (FPN1) iron metabolism axis in cancer cells. Concurrently, the gallium ions (Ga3+) derived from GaSx act as a biochemical "Trojan horse", mimicking the role of iron and displacing it from essential biomolecular binding sites, thereby influencing the fate of cancer cells. By leveraging the dual mechanisms of Ga3+-mediated iron disruption and H2S-facilitated reprogramming of iron metabolic pathways, GaSx prompted the initiation of a paraptosis-apoptosis hybrid pathway in cancer cells, leading to marked suppression of tumor proliferation. Importantly, the dysregulation of iron metabolism induced by GaSx notably increased tumor cell susceptibility to both chemotherapy and immune checkpoint blockade (ICB) therapy. This study underscores the therapeutic promise of gas-based interventions and metal ion interference strategies for the tumor metabolism treatment.

Low-concentration H2S gas sensors based on MOF-derived Co3O4 nanomaterials

Metal-organic frameworks (MOF)-based gas sensors have garnered significant interest and are highly desirable for monitoring indoor air quality and mitigating various environmental reclamation challenges. Herein, we describe a unique approach for fabricating hydrogen sulfide (H2S) gas sensors based on MOF-derived cobalt oxide nanosheets (Co3O4 Ns) nanostructures. The surface morphology and porosity of the fabricated material were confirmed through comprehensive Brunauer-Emmett-Teller (BET) and electron microscopy analyses. Chemical composition and phase purity were identified using Energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The sensor exhibited remarkable sensitivity towards hydrogen sulfide in the range of 0.5–100 ppm, reaching a maximum response of 1702.61 % at an operating temperature of 250 °C for 100 ppm H2S gas. Furthermore, the sensor demonstrated a detection limit of 500 ppb with a response rate of 78.22 %. A consistent stability over 30 days was observed, validating its suitability for real-world applications. The response and recovery times of the H2S gas sensors were assessed with τres/τrec = 63.56/103.34 s, offering valuable insights into their real-world applicability.

Reactive adsorption and catalytic oxidation of gaseous hydrogen sulfide using a prototype air purifier built with bismuth-doped titanium dioxide

A prototype air purifier (AP) module has been constructed using bismuth-doped titanium dioxide (Bix-P25: x(%) as Bi/Ti molar ratios of 1.1, 2.1, 3.3, 5.3, and 8.7). The reactive adsorption property of Bix-P25 materials is evaluated against H2S gas at a recirculation rate of 160 L min−1 in a 17 L closed chamber. The AP (Bi5.3-P25) exhibits superior performance against 10 ppm H2S in dry air under dark conditions (i.e., without light irradiation), with a removal efficiency (XH2S)= 99% in 5 mins, reaction kinetic rate (r (at X = 10%))= 7.3 mmol h−1g−1, and partition coefficient= 0.18 mol kg−1 Pa−1. As such, its superiority is evident over the reference AP (P25) filter with XH2S < 10%. The clean air delivery rate (CADR) of AP (Bi5.3-P25) increases noticeably from 9.9 to 17.8 L min−1 with increasing relative humidity (RH) from 0 to 80%, respectively. In contrast, the CADR decreases from 9.9 to 5.8 L min−1 as the H2S increases from 10 to 20 ppm. According to density functional theory (DFT), the presence of H2O vapor enhances the hydroxylation of Bix-P25 surface to promote H2S mineralization through the formation of TiS3 (i.e., thermodynamic reaction of S atom with the catalytic surface). Complete removal of H2S on the Bi5.3-P25 surface is also confirmed consistently through gas chromatography-mass spectrometry (GC-MS), in-situ diffuse reflection infrared spectroscopy (in-situ DRIFTS), and elemental analysis (EA). This work represents the first utilization of Bix-P25 materials fabricated on an AP platform toward the desulfurization of H2S at room temperature (RT). The practical utility of Bix-P25 is overall validated by its eminent role in reactive adsorption and catalytic oxidation (RACO) of H2S from the air.

Exploring the potential of boron-nitride nanobelts in environmental applications: Greenhouse gases capture

This study examines boron-nitride nanobelts, including Möbius-type, for capturing and detecting nine greenhouse gases (ammonia, carbon dioxide, carbon monoxide, hydrogen sulfide, methane, methanol, nitric dioxide, nitric oxide, and phosgene). Negative adsorption energies indicate favorable adsorption on both nanobelt types. The systems show recovery times ranging between 2 h to few nanoseconds. Only nitric oxide forms covalent bonds; other gases interact non-covalently. Molecular dynamics simulations reveal consistent single-molecule interactions and attractive forces with multiple molecules. Semi-empirical tight-binding methods, as implemented in the xTB software were used for computational efficiency. Results demonstrate the potential of boron-nitride nanobelts for environmental monitoring and remediation of industrial toxic gas emissions, addressing concerns about human health and environmental impact.

Growth boundary of Fusarium graminearum spores as a function of temperature, pH, and H2S based on neural network

Fusarium graminearum (F. graminearum) poses a substantial threat to global food security, with its impact closely linked to environmental conditions. This study aims to anticipate F. graminearum spore growth across diverse environments and assess alterations in the fungistatic capacity of hydrogen sulfide (H2S) gas in response to environmental variations. The experimental data, namely spore germination ratios, are monitored and recorded at hourly intervals across 100 permutations comprising four distinct temperature levels, five varying pH values, and five diverse concentrations of H2S. The investigation integrates three environmental factors as input variables, utilizing a feedforward neural network to establish growth boundaries based on spore germination ratios. The accuracy of models at various stages–training, validation, and testing–is evaluated using a confusion matrix. Logistic regression models are employed for effectiveness comparison with neural networks. Results indicate that neural networks successfully predict F. graminearum spore germination events. Notably, H2S does not influence the temperature preferences of spores. Temperature has a more substantial impact on the fungistatic ability of H2S compared to pH. The study reveals the adaptability of F. graminearum spores to adverse conditions over time. This research delves into temperature, pH, and H2S synergistic effects on spore germination, contributing to predictive models for F. graminearum and enhancing our understanding of how environmental factors regulate its growth.