High-pressure structural search was performed on the hydrogen-rich compound LuBeH8 at pressures up to 200 GPa. We found an structure that exhibits stability and superconductivity above 100 GPa. Our phonon dispersion, electronic band structure, and superconductivity analyses in the 100–200 GPa pressure range reveal a strong electron–phonon coupling in LuBeH8, while the superconducting critical temperature T c shows a decreasing trend as the pressure increases, with T c = 255 K at 200 GPa and maximal T c = 355 K at 100 GPa. This study demonstrated the room-temperature superconductivity in -LuBeH8, thus enriching the family of ternary hydrides. These findings provide valuable guidance for identifying new high-temperature superconducting hydrides.