The aim of this paper is to evaluate the roll-out of a hydrogen refuelling station (HRS) infrastructure in the Member States of Europe Union. The effort contributes to a preliminary, indicative assessment of the commercial viability and profitability of a hydrogen refuelling station network roll-out. In these concrete cases were provided scenarios at both the Member States and Europe Union levels. The business case assessment was realised for the roll-out of HRS network in a 15 years program. The results refer to key metrics to assess the overall profitability of the investment: the annual number evolution of HRSs based on the inputs provided by the user; the annual number evolution of FCEVs; annual total amount of hydrogen sold; annual capital expenditures on HES procurement (CAPEX); cash flow after interest and debt payment representing the cash flow available for equity holders; annual debt service coverage ratio (ADSCR); and net present value (NPV) at the end of the period. The first scenarios were designed to achieve results across the Member States of Europe Union. There were presented three individual detailed examples also. A second series of sensitivity analyses consider that the hydrogen mobility penetration appears more constrained, being limited to a few stakeholders in the EU with well-defined policies and programs or with more favourable conditions. Both categories of scenarios outline the idea that at the beginning of a HRS network development it is already good to have an adequate number of FCEVs for a profitable programme. The net present value (NPV) is positive and the development program is commercially viable if there is a correlation between both the HRS number and FCEV fleet dimension. This correlation leads to good or optimistic results, but for the majority NPV became positive only in the second part of the program.The roll-out's analysis of the hydrogen refuelling station network in the EU indicated that hydrogen is a part of solutions for a decarbonisation of the transport sector. There is a need to carefully develop an adequate hydrogen refuelling infrastructure if the final scope of the program is its commercial viability and profitability.