High-fidelity simulations of RDEs with H2-Air-NOx chemistry are employed to study NOx emissions in such devices. Discrete injection of gaseous hydrogen fuel and continuous injection of air oxidizer is used at various mass flow rate conditions in several 3D RDE simulations to understand resulting NOx production behaviors. Simulations are also performed for two different injector configurations, one in which air is injected axially into the detonation chamber [Axial Air Inlet (AAI)] and one in which air is injected radially [Radial Air Inlet (RAI)]. It is seen that the AAI RDE produces much less NOx than the RAI RDE, mainly due to the weaker waves seen in this system as a result of parasitic combustion losses from product gas recirculation. Parasitic combustion does lead to NOx formation in its own right, but the emissions levels from this process are negligible compared to emissions stemming directly from detonation processes. In regards to detonation strength in particular, it is generally seen that detonation strength increases with increasing mass flow rate, in turn increasing peak pressure, peak heat release and NOx emissions levels. Nevertheless, even the highest recorded NOx levels at the combustor exit in this study remain on the same order of magnitude as compared to gas turbine exhaust emissions levels, supporting the claim that significant differences between detonative and deflagrative combustion do not necessarily lead to significant differences in NOx levels. Overall, this study provides greater understanding into the behaviors of NOx formation in RDEs and how these behaviors are affected by changes in operating parameters.