Hydrodynamic Surface Research Articles

Construction of visible-light-induced Fe2O3/g-C3N4 nanocomposites for the enhanced degradation of organic dyes: Optimization of operative parameters

This research aims to develop the highly promising Fe2O3/g-C3N4 photocatalyst through hydrothermal techniques to cope with the elevated amounts of bromophenol blue (BPB) dye in wastewater. The morphological studies were carried out by SEM analysis, while the crystallinity, structural behavior, and oxidation states of the prepared materials were determined by XRD, FTIR, and XPS analysis. The hydrodynamic size, surface area, and magnetic characteristics of the constructed materials were assessed through DLS, BET, and VSM analysis. The effectivity of the synthesized Fe2O3 and Fe2O3/g-C3N4-30 photocatalysts was appraised by the abatement of BPB under visible light radiation for 48 min. The results have shown an excellent degradation efficacy of Fe2O3/g-C3N4-30 photocatalyst with 98.39 % of BPB removal and a rate constant of 0.0757 min−1, which was much higher than Fe2O3 photocatalyst with 79.64 % of removal and a rate constant of 0.0335 min−1 under optimum conditions. The enhancement in degradation efficiency of the Fe2O3/g-C3N4-30 was due to the large surface area of Fe2O3/g-C3N4-30 (106.94 m2/g) as a result of g-C3N4 inclusion in the material, while the pure Fe2O3 unveiled a surface area of 89.67 m2/g. The impact of different reaction parameters on BPB degradation was also investigated, while the contribution of free radicals was corroborated through radical trapping experiments. The Fe2O3/g-C3N4-30 exhibited tremendous stability for repeated applications, with a loss of 8.03 % in efficiency after five consecutive experiments because of its easy magnetic separation. The experimental results have shown that synthesized Fe2O3/g-C3N4-30 photocatalysts could be used for the effective degradation of BPB from wastewater.

Spray-dried cyclophosphamide-loaded polyhydroxyalkanoate microparticles: design and characterization

Background and purpose: Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and the frequency of its administration, the microencapsulation of CP into biodegradable polymeric matrices can be performed. However, according to the literature, only a few polymers were found suitable to encapsulate CP and achieve its’ sustained release. Experimental approach: In this research, spray-dried cyclophosphamide-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microparticles were prepared and characterized in terms of their average hydrodynamic diameter, polydispersity index, surface morphology, zeta potential, encapsulation efficiency, drug loading, thermal properties and cytotoxicity against 3T3 cells. Key results: The obtained CP-loaded microparticles had a regular spherical shape, uniform size distribution with an average diameter of 4.21±0.04 μm and zeta potential of -34.2±0.2 mV. The encap­sulation of cyclophosphamide into the PHBV matrix led to a decrease in melting and degradation tempe­ratures and an increase in diameter, glass transition and cold crystallization temperatures compared to blank microparticles. Moreover, microencapsulation of cyclophosphamide lowered its cytotoxicity compared to the pure drug: the number of dead cells in the culture decreased by 28 %, while their metabolic activity increased by 20 %. The cumulative in vitro drug release studies showed a gradual release of CP up to 18 days, so the obtained microparticle formulation can be used as a sustained-release cyclophosphamide delivery system. Conclusion: In this research, a novel cyclophosphamide-loaded platform based on PHBV micro­particles was established and characterized. Overall, this study offers promising prospects for cancer therapy in the future.

Investigation of the biological activity and toxicity of bioactive silver nanoparticles synthesized via Vitex agnus-castus seed extract on honey bees.

In this study, silver nanoparticles (AgNPs) coated with bioactive molecules were synthesized via Vitex agnus-castus L. (VAC) seed extract (VAC/AgNPs). The synthesized VAC/AgNPs were characterized by surface plasmon resonance (SPR) ultraviolet-visible region spectroscopy (UV-Vis). The hydrodynamic size and surface charge analysis of the particles were measured with a Zeta sizer. The results of UV-Vis and Zeta analysis revealed that AgNPs were synthesized, the size distribution was nanoscale, and the solution was stable. The effects of the synthesized VAC/AgNPs and aqueous extract of VAC seeds on honeybees were investigated by means of lifespan test and histopathological analysis. It was determined that both VAC seed extract and VAC/AgNPs were non-toxic to honeybees at certain doses, positively affected their life span and contributed to their longevity in the life span test. Furthermore, no adverse effects were detected in terms of intestinal health in histopathological examinations. Therefore, VAC/AgNPs are considered to be a promising bioactive agent for honeybees.

Tiny particles thermal motile in magnetized chemically reacting upper-convective Maxwell stagnation point fluid with radiation

The need to enhance industrial working fluid and material thermal strength for quality output of engineering and domestic devices, has increased diverse studies on non-Newtonian viscous fluid under different constraints. Various architectures and geometries have been considered for thermal propagation of fluid particles. As such, this study addresses thermal motility of tiny particles in magnetized chemically reacting upper-convective Maxwell stagnation point fluid with radiation owing to its usages. A partial-differential model is formulated under some certain assumptions and conditions, and with applicable similarity variables, a transformed invariant coupled ordinary-differential model is obtained. The solutions to the model are determined using Galerkin-weighted residual method. The computed outcomes are quantitatively tabulated and qualitatively demonstrated in graphs. The analysis revealed that the hydrodynamic bounding surface alongside with velocity profiles declines due to augmentation of the magnetic field and Deborah number terms.

Effects of nonlinearity on Anderson localization of surface gravity waves

Anderson localization is a multiple-scattering phenomenon of linear waves propagating within a disordered medium. Discovered in the late 50s for electrons, it has since been observed experimentally with cold atoms and with classical waves (optics, microwaves, and acoustics), but whether wave localization is enhanced or weakened for nonlinear waves is a long-standing debate. Here, we show that the nonlinearity strengthens the localization of surface-gravity waves propagating in a canal with a random bottom. We also show experimentally how the localization length depends on the nonlinearity, which has never been reported previously with any type of wave. To do so, we use a full space-and-time-resolved wavefield measurement as well as numerical simulations. The effects of the disorder level and the system’s finite size on localization are also reported. We also highlight the first experimental evidence of the macroscopic analog of Bloch’s dispersion relation of linear hydrodynamic surface waves over periodic bathymetry.

Data-driven surrogate modelling of multistage Taylor cone–jet dynamics

The Taylor cone jet is an electrohydrodynamic flow typically induced by applying an external electric field to a liquid within a capillary, commonly utilized in colloidal thrusters. This flow generation involves a complex multiphase and multiphysics process, with stability contingent upon specific operational parameters. The operational window is intrinsically linked to flow rate and applied electric voltage magnitude. High voltages can induce atomization instabilities, resulting in the production of an electrospray. Our study presents initially a numerical investigation into the atomization process of a Taylor cone jet using computational fluid dynamics. Implemented within OpenFOAM, our numerical model utilizes a volume-of-fluid approach coupled with Maxwell's equations to incorporate electric body forces into the incompressible Navier–Stokes equations. We employ the leaky-dielectric model, subjecting the interface between phases to hydrodynamic surface tension and electric stress (Maxwell stress). With this model, we studied the droplet breakup of a heptane liquid jet, for a range of operation of 1.53–7.0 nL s−1 and 2.4–4.5 kV of extraction. First, the developed high-fidelity numerical solution is studied for the jet breakup and acceleration of the droplets. Second, we integrate a machine learning model capable of extending the parametric windows of operation. Additionally, we explore the influence of extractor and acceleration plates on colloidal propulsion systems. This work offers a numerical exploration of the Taylor cone–jet transition and droplet acceleration using novel, numerically accurate approaches. Subsequently, we integrate machine learning models, specifically an artificial neural network and a one-dimensional convolutional neural network, to predict the jet's performance under conditions not previously evaluated by computationally heavy numerical models. Notably, we demonstrate that the convolutional neural network outperforms the artificial neural network for this type of application data, achieving a 2% droplet size prediction accuracy.

Modal analysis of a submerged elastic disk: A hypersingular integral equation approach

A method based on the hypersingular integral equation approach and the modal analysis is presented to consider the effects of the motion of a submerged elastic disk on the incoming waves. Initially, the governing boundary value problem is reduced to a two-dimensional integral equation with a hypersingular kernel. This integral equation is further reduced to a one-dimensional Fredholm integral equation of the second kind with the help of Fourier series expansions and a newly defined function. As a part of modal analysis, eigenfunction expansion based on natural modes of structural motion is considered to describe the motion of a thin circular elastic disk. Physical quantities, such as hydrodynamic force, added mass, damping coefficient, and surface elevation, are numerically evaluated. The computed numerical results are verified by comparing them with those for the rigid disk horizontally submerged in deep water. Apart from this, as a part of the analytical verification of our present analysis, the reciprocity relation has been included. The effects of different parameters (disk's rigidity, radius, submergence depth, and mode of vibrations) on the aforementioned physical quantities have been studied. The maximum hydrodynamic force occurs around Ka = 0.5, while the maximum added mass and damping coefficient occur around the wavenumber Ka = 0.3 and Ka = 0.5, respectively. The peaks of the hydrodynamic force and free surface elevation become sharper with the increasing values of the disk's size. The numerical results emphasize that the wave focusing can be controlled by changing the submergence depth, size, and rigidity of the disk.

Clerodendrum chinense Stem Extract and Nanoparticles: Effects on Proliferation, Colony Formation, Apoptosis Induction, Cell Cycle Arrest, and Mitochondrial Membrane Potential in Human Breast Adenocarcinoma Breast Cancer Cells.

Breast cancer stands out as the most widespread form of cancer globally. In this study, the anticancer activities of Clerodendrum chinense (C. chinense) stem ethanolic extract were investigated. High-performance liquid chromatography (HPLC) analysis identified verbascoside and isoverbascoside as the major bioactive compounds in the C. chinense stem extract. Successfully developed nanoparticles exhibited favorable hydrodynamic diameter, polydispersity index, and surface charge, thus ensuring stability after four months of storage. The total phenolic content and total flavonoid contents in the nanoparticles were reported as 88.62% and 95.26%, respectively. The C. chinense stem extract demonstrated a dose-dependent inhibitory effect on MCF-7, HeLa, A549, and SKOV-3 cancer cell lines, with IC50 values of 109.2, 155.6, 206.9, and 423 µg/mL, respectively. C. chinense extract and NPs exhibited dose-dependent cytotoxicity and the highest selectivity index values against MCF-7 cells. A dose-dependent reduction in the colony formation of MCF-7 cells was observed following treatment with the extract and nanoparticles. The extract induced cytotoxicity in MCF-7 cells through apoptosis and necrosis. C. chinense stem extract and nanoparticles decreased mitochondrial membrane potential (MMP) and induced G0/G1 phase arrest in MCF-7 cells. In conclusion, use of C. chinense stem extract and nanoparticles may serve as a potential therapeutic approach for breast cancer, thus warranting further exploration.

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy.

The development of nonviral dendritic polymers with a simple molecular backbone and great gene delivery efficiency to effectively tackle cancer remains a great challenge. Phosphorus dendrimers or dendrons are promising vectors due to their structural uniformity, rigid molecular backbones, and tunable surface functionalities. Here, we report the development of a new low-generation unsymmetrical cationic phosphorus dendrimer bearing 5 pyrrolidinium groups and one amino group as a nonviral gene delivery vector. The created AB5-type dendrimers with simple molecular backbone can compress microRNA-30d (miR-30d) to form polyplexes with desired hydrodynamic sizes and surface potentials and can effectively transfect miR-30d to cancer cells to suppress the glycolysis-associated SLC2A1 and HK1 expression, thus significantly inhibiting the migration and invasion of a murine breast cancer cell line in vitro and the corresponding subcutaneous tumor mouse model in vivo. Such unsymmetrical low-generation phosphorus dendrimers may be extended to deliver other genetic materials to tackle other diseases.

Clearance of nanoparticles from blood: effects of hydrodynamic size and surface coatings

The clearance pathways of nanoparticles from blood following pore penetration and phagocytosis (take the liver and kidney as examples).

Polystyrene nanoplastics alter the ecotoxicological effects of diclofenac on freshwater microalgae Scenedesmus obliquus.

Due to the escalating risk of plastic pollution, nanoplastics have attracted considerable attention in the recent past. They can co-exist and interact with other contaminants like pharmaceuticals in the aquatic environment. Therefore, it is pertinent to understand how these pollutants interact with one another in the ecosystem. The current study examined the individual and combined effects of fluorescent polystyrene nanoplastics (FNPs) and diclofenac (DCF) on Scenedesmus obliquus using a full factorial design. The toxicity of S. obliquus significantly increased in a dose-dependent manner upon exposure to pristine forms of DCF and FNPs. The major cause of individual toxicity of DCF and FNPs in S. obliquus was oxidative stress. In the combined toxicity tests when FNPs (0.01, 0.1, and 1 mg L-1) and DCF (1 mg L-1) were mixed, a synergistic effect was noted compared to the respective pristine FNPs. However, when the DCF concentration in the mixture was decreased to 0.25 mg L-1, the combined toxicity with FNPs (0.01, 0.1, and 1 mg L-1) reduced indicating an antagonistic effect. The independent action model also showed an antagonistic effect for low-dose combinations of DCF and a synergistic effect for high-dose combinations. The estimation of oxidative stress parameters, antioxidant enzyme activity, and photosynthetic pigment content in the algae further validated the cytotoxicity data. The mean hydrodynamic diameter and surface charge analyses further indicated that the colloidal stability of the FNPs in the medium was affected when they were combined with DCF. The key reason for differences in the cytotoxicity of combinations could be observed variations in the aggregation of FNPs and differential adsorption patterns of DCF on the FNPs. These factors efficiently altered cell-particle interactions in the mixture demonstrating a hormesis effect. Thus, this current study highlighted the hazardous nature of the nanoplastics and their co-exposure risks with pharmaceuticals on microalgae in freshwater environments.

Scuffing failure analysis based on a multiphysics coupling model and experimental verification

AbstractGeneral reductions in lubricant viscosities and increasing loads in machine components highlight the role of tribofilms in providing surface protection against scuffing. However, the relationship between the scuffing process and the growth and removal of tribofilm is not well understood. In this study, a multiphysics coupling model, which includes hydrodynamic lubrication, asperity contact, thermal effect, tribochemistry reaction, friction, and surface wear, was developed to capture the initiation of surface scuffing. Simulations and experiments for a piston ring and cylinder liner contact were conducted following a step-load sequence under different temperature conditions. The results show that high temperature and extreme load could induce the lubricant film collapse, which in turn triggers the breakdown of the tribofilm due to the significantly increased removal process. The failures of both lubricant film and tribofilm progress instantaneously in a coupling way, which finally leads to severe scuffing.

Preparation of protein nanoparticles using diselenide functionalized gelatin for redox responsive release of doxorubicin

The present study demonstrates the fabrication of a nanocarrier system using diselenide conjugated gelatin (G-Se-Se-G) for the redox responsive delivery of a wide spectrum anticancer drug, doxorubicin (Dox). The method involves nanoprecipitation of the aqueous solution of G-Se-Se-G employing ethanol and F68 as the desolvating and stabilizing agents respectively. The drug, Dox is loaded within the nanocarrier by entrapment method during the nanoparticle synthesis. The physico-chemical characterizations confirm the formation of nanoparticles of regular spherical shape with hydrodynamic size, surface charge and loading efficiency of 181 ± 12.6 nm, -13.10 ± 0.83 mV and ∼9 % respectively. Notably, Dox loaded G-Se-Se-G carrier shows significantly higher drug release in response to acidic (pH = ∼5.5) and reducing (10 mM glutathione) sink conditions. Dox release kinetic data fitted to a universal Korsmeyer–Peppas model suggests that irrespective of the nature of stimuli, the release of Dox from G-Se-Se-G carrier follows non-Fickian mechanism which is attributed to the diffusion and erosion. The cytotoxicity studies employing human lung adenocarcinoma (A549) and human normal lung fibroblast (WI38) cells confirm the potency as well as selectively of Dox loaded G-Se-Se-G carrier towards cancer cells. The intracellular drug release studies through fluorescence imaging indeed corroborate the redox (reducing environment) mediated preferential release of Dox from G-Se-Se-G carrier in A549 cells as compared to WI38 cells. Finally, in vivo studies using A549 derived xenograft tumor model establishes that Dox loaded G-Se-Se-G nanocarrier is better tolerable than free Dox with almost similar efficacy.

Moist Heat Synthesis of Magnetic EGCG-Cappedα-Fe2O3 Nanoparticles and Their In Vitro and In Silico Interactions with Pristine HSA- and NDM-1-Producing Bacteria.

A simple, facile, moist-heating (e.g., autoclave), one-step procedure for EGCG-mediated biosynthesis of narrow-size magnetic iron oxide (α-Fe2O3) nanoparticles (EGCG-MINPs) was developed. The influence of pH of the reaction mixture over the size distribution of as-synthesized EGCG-MINPs was investigated systematically by employing UV-visible (UV-vis) spectroscopy and dynamic light scattering (DLS)-based hydrodynamic size, surface charge (zeta-potential), and polydispersity index (PDI). The FE-SEM, TEM, and XRD characterizations revealed that the EGCG-MINPs synthesized at pH 5.0 were in the size range of 6.20-16.7 nm and possess well-crystalline hexagonal shaped nanostructures of hematite (α-Fe2O3) crystal phase. The role of EGCG in Fe3+ ion reduction and EGCG-MINP formation was confirmed by FTIR analysis. The VSM analysis has revealed that EGCG-MINPs were highly magnetic nanostructures with the hysteretic feature of saturation magnetization (Ms), remanent magnetization (Mr), and coercivity (Hc) as 33.64 emu/g, 12.18 emu/g, and 0.33 Oe, respectively. Besides, significant (p < 0.001) dose-dependent (250-1000 μg/mL) antibacterial and antibiofilm activities against the NDM-1-producing Gram-negative Escherichia coli (AK-33), Klebsiella pneumoniae (AK-65), Pseudomonas aeruginosa (AK-66), and Shigella boydii (AK-67) bacterial isolates warranted the as-synthesized EGCG-MINPs as a promising alternative for clinical management of chronic bacterial infections in biomedical settings. In addition, molecular docking experiments revealed that compared to free Fe3+ and EGCG alone, the EGCG-MINPs or Fe-EGCG complex possess significantly high binding affinity toward HSA and hence can be considered as promising biocompatible nanodrug carriers in in vivo drug delivery systems.

Selenium‐doped albumin nanoparticles enhance tamoxifen‐induced anticancer effects in 4T‐1 mouse breast cancer cells

In this study, we aimed to improve the delivery and efficacy of the well‐known anticancer drug, tamoxifen (TAM), through its encapsulation in bovine serum albumin nanoparticles (BSA NPs) and their hybridization with selenium nanoparticles (Se NPs). The developed nanostructures were characterized by Fourier transform infrared (FT‐IR) spectroscopy, ultraviolet–visible (UV–Vis) spectroscopy, energy‐dispersive X‐ray spectroscopy (EDS) analysis, dynamic light scattering (DLS), and field emission scanning electron microscopy (FESEM) imaging. The impact of nanostructures on 4T‐1 cancer cells was assessed through MTT and flow cytometry assays to measure cytotoxicity and apoptosis rates, respectively. FT‐IR and UV–Vis spectroscopy confirmed the successful encapsulation of TAM within BSA NPs. EDS analysis confirmed the Se integration into BSA‐TAM@Se NPs, signifying successful hybridization. Size and zeta potential measurements revealed the average hydrodynamic size and surface charge of the nanostructures. BSA NPs, BSA@Se NPs, and Se NPs showed the sizes ranging from 153.37 ± 1.02 to 229.63 ± 1.36 nm, with zeta potential values from −10.12 ± 0.26 to −28.45 ± 0.40 mV. Hemocompatibility studies demonstrated minimal hemolytic activity of the nanostructures, indicating their biocompatibility for intravenous administration. Cellular toxicity assays showed higher cytotoxicity of BSA‐TAM@Se NPs compared to other formulations (****p &lt; 0.0001). The increased cell death in 4T‐1 breast cancer cells highlights the enhanced therapeutic potential of BSA‐TAM@Se NPs. Apoptosis analysis revealed a significant increase in apoptosis rate in 4T‐1 cells treated with BSA‐TAM@Se NPs compared to other formulations (****p &lt; 0.0001), emphasizing their ability to induce programmed cell death. These findings support the rational importance of BSA NPs as drug nanocarriers and their hybridization with Se NPs to improve therapeutic effects. Finally, we suggest that the developed BSA‐TAM@Se NPs can be used as a potential therapeutic approach in combination with other tools such as X‐ray irradiation in future studies.

BEM modelling of a hydrodynamic lifting surface working in ground proximity

Present paper aims to assess the performance and limits of boundary element method for the reliable simulation of ground effect phenomena on hydrodynamic lifting surfaces. Benefitting from the ground effect, especially in extreme ground proximity, suggests a promising concept for lifting bodies. On the other hand, the more pronounced the ground effect, the more complicated flow physics it exhibits, making the problem harder to handle numerically. In this study, a potential-based boundary element method (BEM) is applied to the flow past a 3D rectangular wing within a wide range of ground clearances corresponding to out of ground effect (OGE), in ground effect (GE) and extreme ground effect (EGE) conditions. Both positive and negative angles of attack are tested to examine the lift and downforce producing cases. The potential flow around the airfoil is computed using the mixed constant-strength source and constant-strength dipole based panel method. The results show that BEM successfully predicts the lift force variation for a wing working in ground proximity (GE). However, approaching the bounds of extreme ground effect is seen to introduce a progressive decrease of the fidelity of the method. A similar tendency is observed in the downforce generating conditions, which is also an important scenario for ground vehicle aerodynamics. BEM remarkably overestimates the magnitude of the downforce when the ground clearance reaches up to the EGE conditions, still, it produces quite satisfactory results for the rest of the tested configurations. The pressure distributions are also provided to examine the flow field in the aforementioned cases. Overall, the results lead us to conclude that BEM stands as a robust and reliable prediction tool for ground effect on 3D wings but the extreme ground effect condition represents the limit of its accuracy range.

Preliminary examination of sounds produced by Pacific salmon (Oncorhynchus spp.) during their fall spawning migrationa).

A preliminary description of sounds produced by three species of Pacific salmon was conducted to address the lack of quantified call characteristics in previous studies. Wild Chinook salmon (Oncorhynchus tshawytscha), pink salmon (O. gorbuscha), and coho salmon (O. kisutch) were diverted from a natural spawning migration in the Big Qualicum River located on Vancouver Island, British Columbia, Canada and held in the adjacent hatchery during the 2017 fall migration. Underwater sounds were opportunistically recorded continuously over four week in holding raceways containing Chinook only, coho only, or mixed pink and Chinook salmon, and examined for sounds. All groups produced sounds in three categories based on mechanism: hydrodynamic (surface splash), air movement (miscellaneous and 7 named types), and unknown mechanism (pulse). Pulse, gill-bubble fast repetitive tick air movement sounds, and miscellaneous air movement sounds occurred in all groups and differences in some characteristics of sounds were found between the species groups. Additionally, even though pink salmon were not recorded separately, data suggest they produce a very fast repetitive tick air movement sound more often compared to Chinook salmon. Our results represent the first detailed description of the types and characteristics of sounds produced by wild Pacific salmon.

A Novel Experimental Approach to Understand the Transport of Nanodrugs.

Nanoparticle-based drugs offer attractive advantages like targeted delivery to the diseased site and size and shape-controlled properties. Therefore, understanding the particulate flow of the nanodrugs is important for effective delivery, accurate prediction of required dosage, and developing efficient drug delivery platforms for nanodrugs. In this study, the transport of nanodrugs including flow velocity and deposition is investigated using three model metal oxide nanodrugs of different sizes including iron oxide, zinc oxide, and combined Cu-Zn-Fe oxide synthesized via a modified polyol approach. The hydrodynamic size, size, morphology, chemical composition, crystal phase, and surface functional groups of the water-soluble nanodrugs were characterized via dynamic light scattering, transmission electron microscopy, scanning electron microscopy-energy dispersive X-ray, X-ray diffraction, and fourier transform infrared spectroscopy, respectively. Two different biomimetic flow channels with customized surfaces are developed via 3D printing to experimentally monitor the velocity and deposition of the different nanodrugs. A diffusion dominated mechanism of flow is seen in size ranges 92 nm to 110 nm of the nanodrugs, from the experimental velocity and mass loss profiles. The flow velocity analysis also shows that the transport of nanodrugs is controlled by sedimentation processes in the larger size ranges of 110-302 nm. However, the combined overview from experimental mass loss and velocity trends indicates presence of both diffusive and sedimentation forces in the 110-302 nm size ranges. It is also discovered that the nanodrugs with higher positive surface charges are transported faster through the two test channels, which also leads to lower deposition of these nanodrugs on the walls of the flow channels. The results from this study will be valuable in realizing reliable and cost-effective in vitro experimental approaches that can support in vivo methods to predict the flow of new nanodrugs.

Integration of numerical models to simulate 2D hydrodynamic/water quality model of contaminant concentration in Shatt Al-Arab River with WRDB calibration tools

Abstract The hydrodynamic model is essential for building a water quality model for rivers, lakes, estuaries, and other water systems. Most model software, such as HEC-RAS, can perform a complex hydrodynamic surface water body and limitations to represent water quality for the corresponding area. In contrast, other models, like WASP, can simulate a wide range of contaminants in a multidimensional geometry of rivers, estuaries, lakes, and reservoirs. Still, it requires flow information from separate hydrodynamic models. This article aims to develop a comprehensive water quality model of the Shatt Al Arab River south of Iraq by linking HEC-RAS with WASP. A variety of software techniques has sequentially been used. This software includes GIS for DEM modification, HEC-RAS for the hydrodynamic model, Python code with PyCharm to run the external coupler, WASP software for advective and dispersive contaminant transport, and finally, WRDB software for full calibration process and results display. The results showed successful transportation of flow information had been achieved. Moreover, the article described an effective calibration process by plotting comparison graphs and statistical summaries to make the appropriate decision. Another goal of this work is to collect the equations and associated reaction rates of source/sink kinetic for eutrophication’s state variables.

Multi-modal sensor fusion towards three-dimensional airborne sonar imaging in hydrodynamic conditions

Analogous to how aerial imagery of above-ground environments transformed our understanding of the earth’s landscapes, remote underwater imaging systems could provide us with a dramatically expanded view of the ocean. However, maintaining high-fidelity imaging in the presence of ocean surface waves is a fundamental bottleneck in the real-world deployment of these airborne underwater imaging systems. In this work, we introduce a sensor fusion framework which couples multi-physics airborne sonar imaging with a water surface imager. Accurately mapping the water surface allows us to provide complementary multi-modal inputs to a custom image reconstruction algorithm, which counteracts the otherwise detrimental effects of a hydrodynamic water surface. Using this methodology, we experimentally demonstrate three-dimensional imaging of an underwater target in hydrodynamic conditions through a lab-based proof-of-concept, which marks an important milestone in the development of robust, remote underwater sensing systems.