It is challenging to investigate the transport and dispersion of contaminants in river confluence areas due to the complex flow dynamics. In recent studies on the flow dynamics in river confluence areas, it has been revealed that changes in inflow conditions (discharge ratio, width-depth ratio and concentration difference) can greatly influence pollutant diffusion. In this study, an asymmetric confluence-type river is modeled by a three-dimensional hydrodynamic water quality model, and three hydrodynamic scenarios are numerically simulated. The results show that a higher discharge ratio and width-depth ratio led to an increase in the lateral diffusion area of pollutants, deviation in the trajectory line of the mixing interface towards the opposite bank of the interchange, and an increase in the mixing rate of pollutants. For R = 0.267 and b/h = 3.75, the pollutants at the bottom are completely mixed in the exit end section. However, the difference in the pollutant concentration slightly affects the area, length and shape of the pollutant dispersion zone and notably affects only the concentration in each section.