This work integrates detailed geological and hydrogeological information with PSI data to obtain a better understanding of subsidence processes detected in the detrital aquifer of the Vega de Granada (SE Spain) during the past 13years. Ground motion was monitored by exploiting SAR images from the ENVISAT (2003–2009), Cosmo-SkyMed (2011–2014) and Sentinel-1A (2015–2016) satellites. PSInSAR results show an inelastic deformation in the aquifer and small land surface displacements (up to −55mm). The most widespread land subsidence is detected during the ENVISAT period (2003–2009), which coincided with a long, dry period in the region. The highest displacement rates recorded during this period (up to 10mm/yr) were detected in the central part of the aquifer, where many villages are located. For this period, there is a good correlation between groundwater level depletion and the augmentation of the average subsidence velocity and slight hydraulic head changes (<2m) have a rapid ground motion response. The Cosmo-SkyMed period (2011–2014) coincided with a rainy period, and the land subsidence is only concentrated in some points. Rates of average subsidence up to 11.5mm/yr are obtained for this period and are anthropogenic in origin, being related to earthmoving works. During the Sentinel-1A monitoring period (2015–2016) most of the region showed no deformation, except for some points of unknown origin in the NE sector. A general conclusion is that there is a clear lithological control in the spatial distribution of ground subsidence; all the subsiding areas detected are located where a higher clay content was identified. Although the SE sector of the aquifer had more intense groundwater exploitation, no land subsidence processes were detected, as coarse-grained sediments predominate in the substratum. This research will contribute to the drawing-up of a management plan for the sustainable use of this strategic aquifer, taking into account critical levels of groundwater depletion to avoid land subsidence in the areas identified as vulnerable. The European Space Agency satellite Sentinel-1A could be an effective decision-making tool in the near future.