Hyde Park Research Articles

Heterogeneity between Two α Subunits of α2β2 Human Hemoglobin and O2 Binding Properties: Raman, 1H Nuclear Magnetic Resonance, and Terahertz Spectra.

Following a previous detailed investigation of the β subunit of α2β2 human adult hemoglobin (Hb A), this study focuses on the α subunit by using three natural valency hybrid α(Fe2+-deoxy/O2)β(Fe3+) hemoglobin M (Hb M) in which O2 cannot bind to the β subunit: Hb M Hyde Park (β92His → Tyr), Hb M Saskatoon (β63His → Tyr), and Hb M Milwaukee (β67Val → Glu). In contrast with the β subunit that exhibited a clear correlation between O2 affinity and Fe2+-His stretching frequencies, the Fe2+-His stretching mode of the α subunit gave two Raman bands only in the T quaternary structure. This means the presence of two tertiary structures in α subunits of the α2β2 tetramer with T structure, and the two structures seemed to be nondynamical as judged from terahertz absorption spectra in the 5-30 cm-1 region of Hb M Milwaukee, α(Fe2+-deoxy)β(Fe3+). This kind of heterogeneity of α subunits was noticed in the reported spectra of a metal hybrid Hb A like α(Fe2+-deoxy)β(Co2+) and, therefore, seems to be universal among α subunits of Hb A. Unexpectedly, the two Fe-His frequencies were hardly changed with a large alteration of O2 affinity by pH change, suggesting no correlation of frequency with O2 affinity for the α subunit. Instead, a new Fe2+-His band corresponding to the R quaternary structure appeared at a higher frequency and was intensified as the O2 affinity increased. The high-frequency counterpart was also observed for a partially O2-bound form, α(Fe2+-deoxy)α(Fe2+-O2)β(Fe3+)β(Fe3+), of the present Hb M, consistent with our previous finding that binding of O2 to one α subunit of T structure α2β2 tetramer changes the other α subunit to the R structure.

Measured short-term subsurface ground displacements from EPBM tunnelling in London Clay

Subsurface ground displacements from the construction of the twin-bore Crossrail tunnels in London Clay by earth pressure balance machines (EPBMs) are presented and discussed, complementing a companion paper by the authors that focused on the surface response. Both papers report vertical and horizontal displacements, in this case measured using comprehensive arrays of instruments installed within boreholes in Hyde Park, London. The Crossrail tunnels are deeper than those cited in most UK case histories concerning tunnelling in stiff clay. Clear insights were gained into subsurface displacement mechanisms: an ‘inward’ displacement field was observed around the Crossrail tunnel construction, in contrast to the ‘outward’ displacement field that developed around the shallower Channel Tunnel Rail Link tunnels constructed east of London using similar EPBMs in London Clay. This has important implications when estimating subsurface displacements using currently available empirical methods. Appraisal of the EPBM operational variables suggests that the relative magnitude of face and tail grout pressures to overburden stress is the key factor contributing to the opposing senses of the observed displacement fields. Earlier tunnelling-induced strain softening of the London Clay is evident from greater subsurface incremental volume losses and settlement trough width parameters relating to subsequent tunnel construction.

Numerical investigation of the effects of tunnelling on existing tunnels

Construction of the Crossrail tunnels just beneath the existing Central line tunnels at the northern side of Hyde Park provided the impetus for this paper. A basic three-dimensional (3D) finite-element (FE) model was developed to study a general case of a new tunnel (NT) crossing perpendicularly below an existing tunnel (ET). A series of 3D FE analyses was carried out and the results presented in this paper reveal some of the interaction effects. Changes in hoop forces, bending moments and lining deformations of the ET due to excavation of the NT are discussed. Conclusions are drawn about how the relative position of the excavation face of the NT in relation to the ET's axis affects the latter's behaviour. Cross-sectional and longitudinal deformations of the ET are discussed, leading to recommendations for field monitoring of similar interaction cases. Two parametric studies were also carried out to quantify the effects of the magnitude of the earth pressure balance machine face pressure and the longitudinal stiffness of the ET on the predicted behaviour of the ET due to construction of the NT.

Spatial distribution patterns of phosphorus in top-soils of Greater London Authority area and their natural and anthropogenic factors

Soil phosphorus (P) has a strong impact on soil and water quality. Soils in urban areas tend to enrich P, however, they have not been adequately investigated. A total of 6467 top-soil samples were collected and analysed by the British Geological Survey, providing basic data for studying the top-soil P distribution patterns and their environmental implications. The hotspots and cool spots were identified using the index of local Moran's I, which is a powerful methodology for discerning spatial clusters and spatial outliers. Combined with the results of one-way analysis of variances (ANOVA), a strong natural control of P was illustrated with elevated concentrations in areas of alluvium and river terrace deposits. P concentration in the lower Thames Estuary was clearly influenced by the tidal effect which has diluted the P-enriched sediments. The high concentration of Si and low pH level were linked to the low value clusters of P in Hyde Park and Richmond Park. Besides the natural control, the high value clusters concentrated in the city centre and built-up area, which indicated soil P content was strongly affected by human activities. The results of a t-test also showed the significant distinction of P concentrations between urban area and non-urbanised area, implying that urbanization and built-up materials accounted mostly for the locations and magnitude of the P pool. To conclude, the spatial patterns of P observed in the study area were controlled by both natural (parent materials (PMs) and geomorphology) and anthropogenic (urbanization) factors.

Measured short-term ground surface response to EPBM tunnelling in London Clay

Earth-pressure-balance machines (EPBMs) were used for the construction of Crossrail tunnels in London, providing opportunities for field investigation of consequent ground response. Analysed results from an instrumented research site in Hyde Park with extensive surface and subsurface monitoring arrays are presented and discussed. The Crossrail tunnels at the site are 34·5 m below ground, deeper than those in most case histories of tunnelling in stiff clay in the UK. This paper characterises the tunnelling-induced ground response, both ‘greenfield’ and in the proximity of the existing Central Line tunnels, dealing with measurements at the ground surface. A companion paper covers the subsurface ground response. Vertical and horizontal ground surface displacements were obtained from manual precise levelling and micrometer stick measurements. Several key findings will benefit future tunnelling projects involving EPBMs. Volume loss values measured at the instrumented site were low, being less than 0·8% and 1·4% for the first and second tunnel drives respectively, higher values being associated with ground softening from the first tunnel construction. Smaller volume losses were recorded in the vicinity of the existing Central Line tunnels, compared with the greenfield location, suggesting that their presence inhibited the development of ground movements. Asymmetric settlement troughs developed due to either the nearby pre-existing tunnels or the construction of the first tunnel. Marginally smaller values of trough width parameter, Ky, were determined for these deeper tunnels compared with previous greenfield ground case histories. Resultant vectors of ground surface displacement were directed to well-defined point-sinks above the tunnel axis level.

A Comedian Sees the World

A Comedian Sees the World

Conversando con... Kathryn Gustafson

<p>Kathryn Gustafson es una paisajista norteamericana reconocida a nivel internacional. Tras estudiar arte y diseño de moda, se formó como paisajista en Francia, en la Escuela de Versalles. En este país realizó sus primeras obras, entre las que destacan los mágicos Jardines de L´Immaginaire. Actualmente, Kathryn Gustafson desarrolla su práctica profesional a través de dos estudios diferentes: Gustafson Porter, afincado en Londres, y Gustafson Nicol Guthrie, con oficinas en Seattle. Entre sus obras más relevantes podemos citar el parque cultural de la Westergasfabriek en Amsterdam o el Lurie Garden, en el Millenium Park de Chicago, el memorial de la princesa Diana en Hyde Park, su propuesta para la 11ª Bienal de Venecia y el proyecto ganador del concurso para Union Square, en el National Mall de Washington.</p><p>La obra de Kathryn Gustafson ha sido ampliamente publicada internacionalmente, y ha obtenido un número impresionante de premios y distinciones. Algunos de los más recientes son el Arnold Brunner Memorial Prize in Architecture de 2012, de la Academia Americana de Artes y Letras, en reconocimiento a su contribución a la arquitectura como arte, y el premio Obayashi en 2014. Kathryn Gustafson recibió en 2015 un Doctorado Honoris Causa por la Universitad Politècnica de València.</p><p>Kathryn Gustafson ha tenido siempre una voz propia dentro del paisajismo contemporáneo, una voz relevante, innovadora y significativa en muchos aspectos. Esta voz destaca, especialmente, por la forma en que aborda el modelado del terreno en sus proyectos, un modelado escultural y sensual, que podemos apreciar también en su proyecto para el Parque Central de Valencia, un proyecto que surge como resultado de un concurso internacional, en el que Gustafson Porter, junto con las Ingenierías Nova y Grupotec y el estudio Borgos Pieper, presentó una propuesta que recibió el primer premio, suscitando después una opinión favorable absolutamente unánime.</p>

The Kensington Gardens and the Solstices

Here we discuss the orientation of two avenues of the Kensington Gardens along the sunrise on solstices. The Kensington Gardens are one of the Royal Parks of London. The gardens are covering an area of 270 acres, and, with the Hyde Park, Green Park, and St. James's Park form an almost continuous green area in London.

A Trustworthy Collaboration: Eleanor Roosevelt and Martha Graham’s Pioneering of American Cultural Diplomacy

The article analyzes Eleanor Roosevelt’s intricate and innovative relationship with American arts during a time when Americans did not believe yet in the power of the arts in making (and un-making) political and diplomatic statements. Focusing on the collaboration between the First Lady and the modern dancer Martha Graham, it also proves that their partnership and its valuable and long lasting outcomes qualify them as pioneers of American cultural diplomacy. As the article shows, Roosevelt invited Martha Graham to perform “American Document” at the White House when the USA was contemplating its entrance in the Second World War. Like in the case of Marion Anderson’s invitation, Graham’s performance of modernism and patriotism was by no means a social event, but a conscientious decision to use the arts in the service of politics and diplomacy. The article follows Roosevelt’s visionary involvement in the inception of American cultural diplomacy during the early fifties, when the former First Lady, now a recognized politician and savvy diplomat on her own, used her prestige and connections in helping Graham during her tours in Europe. Accompanied by the American Ambassador David Bruce, Roosevelt attended Graham’s opening night in Paris, during the dancer’s difficult first European tour in 1950. Subsequently, when Roosevelt’s old friend, Queen Juliana of the Netherlands, visited Hyde Park in 1952, she orchestrated the Queen’s meeting with Graham in New York City. On the occasion of Graham’s second European tour, in 1954, the Queen attended one of her performances, which was an unprecedented diplomatic and audience success for the dancer and American diplomacy in Europe. Based on research in archives, as well as public and private collections from the USA, The Netherlands, Britain and France, the article is not only a historical reconstruction of a special collaboration, but also an homage to the two fascinating First Ladies – of politics and dance – who pioneered American cultural diplomacy.

HAMILTON’S DERACIALIZATION

AbstractMany commentators have described Barack Obama as a ‘deracialized’ politician. In contrast to ‘racialized’ Black candidates, deracialized politicians are said to deemphasize their Black racial identity, downplay the racial legacies of American inequality, and favor race-neutral over racially targeted policies. Puzzlingly, this narrative of Obama’s racial politics sits incongruously with his politicalcurriculum vitae, spent largely in contexts which are difficult to describe as deracialized. This article holds that commentators have misjudged Barack Obama’s racial politics by conflating a contingent electoral strategy with a deeper expression of Obama’s racial philosophical commitments. In explaining these commitments, the article finds the deracialized/racialized framing inadequate. Instead, it favors the typology of racial policy alliances situating Obama within the “race-conscious” policy alliance rather than the “color-blind” alliance. By returning to the site of Obama’s political development, Hyde Park in Chicago, the paper uncovers a tradition of racial politics in which Blacks formed coalitions with progressive Whites but also embraced Black racial identity, acknowledged the enduring legacies of slavery and Jim Crow, and supported targeted policies to overturn these racial legacies. The article argues that Obama was an inheritor of this tradition.

Angel at the Gate

Angel at the Gate* Nathaniel Mackey (bio) —”mu” one hundred seventy-first part— “The metaphysical wishes of the body,” I’d read in Wilson’s book.A passerby with a beehive hairdo con- firmed it. Sister C and I steppedoff the bus. Was it body’s wish to rise above or to add to itself I won- dered out loud, a wish for more body or a wish to be more than body, a wish to be rid of itself. Thelady with the beehive hairdo wore a par- rot-feather boa, twinning her hair’s wish to be wing, Sister C said, tobe word, to be sigh, to be sign, to be book . . . A passerby with a scarlet Afro walked by next, frizz and flaming col- or of another world Sister C pointed out, bodily whisk as soon as it got soon gone, sad end it all comes to callingback as he passed out of sight. So it was we thought about time, vain pursuit. Had a passerby decked out in peacock feathers come next I’d’ve sighed . . . I want- [End Page 141] ed nothing if not to climb a soapbox, nothing if not to send an amen Wilson’sway, say something about soul, no body not soul’s effect, the buzz, the lowered eyes, the bitten lip. Come with us upthe Mountain of the Night Abdullah called from the box, one glamor come back, a lost or a last flare it seemed . . . I was hold-ing what came to hand, trying to hold on, contingency’s dictates contingency’s angel, soul body’s wish, viceversa [End Page 142] ________ We stepped off the bus to the plat-form, the podium, pulpit, lectern, bullhorn, soapbox I wanted it to be. Ab- dullah had my back I could hear, baritone reach, baritone bottom, no matter rectitude met lament. I stood tall affecting nothing if not stateli- ness, stately aplomb I wanted my address to come off with. I stood float- ing many a metaphysical notion, soul’s bodily tenancy one of them but only one, something seen in a face no face itself made good on, I lift-ed my arm, my heart above my head . . . I stood stately floating many a sensate no- tion. “Mouth be my witness,” I swore, “nose be my witness.” Mountain of the Night notwithstanding, the blue star toobright to be looked at bore down on us. “Eye, ear, sphincter, genital opening be my witness. Bodily gate be my witness,” Iswore. Sister C held my hand as I spoke, amen’d my every thought. Bodily gate bond- ed her book she avowed . . . We were in Hyde Park, the Speakers’ Corner. We were in back of the East Bay it seemed, thesense of being a band or in a band upon us again, the Dialectical Sound Ensemble the band we’d be, this or that drummed af- fliction’s dreamt relief . . . Got there clue-less, remained the same no matter, I toed a tight Heraclitean line, truth be told truth hid- den, the appeal of parts notshown [End Page 143] ________ I toed a strict Ogotemmêlian line, thewonder we wear nothing underneath no wonder, body’s metaphysical wish the wish it were so . . . Soul’s bodily wish was two lovers’ wish to be one I held forth, polis’s wish to be one we of like order. I spoke in search of clime, truth be told a hidden truth, hidden treasure, familiarity’s wear warded off [End Page 144] Nathaniel Mackey Nathaniel Mackey, editor of the experimental literary journal Hambone and former Chancellor of the Academy of American Poets (2001–2007), is author of a number of volumes poems and fiction, including Bass Cathedral (volume four of his ongoing serial fiction From a Broken Bottle Traces of Perfume Still Emanate, 2008), Bedouin Hornbook (fiction, 1986), Splay Anthem (poetry, 2006), Nod House (poetry, 2011), and Blue Fasa (poetry, 2015). He is also author of two books of literary and cultural criticism, Discrepant Engagement: Dissonance, Cross-Culturality, and Experimental Writing (1993) and Paracritical Hinge: Essays, Talks, Notes, Interviews (2005). His numerous honors and awards include...

“To Talk of Many Things”: Chaotic Empathy and Anxieties of Victorian Taxidermy in Alice’s Adventures in Wonderland

“To Talk of Many Things”: Chaotic Empathy and Anxieties of Victorian Taxidermy in Alice’s Adventures in Wonderland Lin Young (bio) The eponymous heroine of Lewis Carroll’s Alice’s Adventures in Wonderland (1865) traverses a mad dreamscape, one in which playing cards are employed as gardeners, flamingos serve as croquet mallets, and white rabbits wear waistcoats. For the Victorian Alice, the fantastical absurdity of Wonderland lies in the notion that the capacity for consciousness, identity, and employment extends from human to animal to object. At precisely the same time that Carroll was dreaming up these categorically confused characters, the world of Victorian taxidermy was undergoing a series of crucial changes that saw seemingly straightforward animal bodies designed for the natural history display evolve into charming and charismatic anthropomorphic creatures. When placed in the larger context of the Victorian preoccupation with natural history and the rise of anthropomorphic taxidermy as a popular entertainment, Carroll’s representation of a tangled hierarchy of consciousness can be understood as a subversion of the nineteenth century’s appetite for a categorical and governable natural world that must, in some way, address the ever-shifting role of the human within that world. This paper will argue that the modes of being as understood by the Victorians—namely, those of human, animal, and object—exist in Alice’s Adventures in Wonderland as products of an imagined process of assembly and disassembly. By exploring three distinct representations of “assembled” identity in the text—the human-object, the animal-object, and the human-animal— I will demonstrate that Carroll extends the capacity to be rendered down into parts (and, by extension, to be reassembled into alternative shapes) to all three imagined categories of being, removing the delineating lines between human, animal, and object in such a way that the individual features of each particular group become interchangeable with those of other groups. The result of this is twofold: first, it enables us to read the epistemic anxieties inherent in the display and organization of the Victorian natural history museum into Alice’s Adventures in Wonderland, particularly as they are reflected in the evolution of taxidermy from a purely categorical, instructional tool that insists on the separation of identities, into the realm of anthropomorphism, which imagines a kind of blended identity. Second, by engaging with these anxieties and extending the capacity for objecthood to all categories of being, [End Page 47] Alice’s Adventures in Wonderland can be situated as a key text in the evolution of the Victorian it-narrative and its increasing concern for the faculty of empathy, allowing for a kind of “object identity” to exist without the structures of human ownership.1 This paper thus identifies Alice’s Adventures in Wonderland as a vital intersection between two evolving modes of Victorian observation—the human observation of the animal-object and the imagined reversal of that gaze in the animal-object’s observation of the human. In understanding Alice’s Adventures in Wonderland as a product of these two prototypical Victorian approaches to increasingly tenuous hierarchies among human, animal, and object, we must read Wonderland as both the result and the embodiment of an extended rearrangement and reconfiguration of the catalogue of life in the nineteenth century. Critics have long noted that Lewis Carroll had some interest in natural history, and particularly so during Alice’s Adventures in Wonderland’s period of production: he was a regular museum-goer, and his diary records his desire to “borrow a Natural History to help in illustrating Alice’s Adventures” (Diaries 193), though the potential influence of taxidermy on his work has thus far been overlooked. Arguably this influence began in 1851, when he was said to have attended the Great Exhibition in Hyde Park, London. The Great Exhibition is particularly notable for introducing the Victorian public to the anthropomorphic taxidermy of Hermann Ploucquet, whose animal tableaux involving “frogs having a shave, kittens serving tea, and a marten acting as a schoolmaster” (Morris 4–5) were immensely popular with the Victorian public; the Illustrated London News published illustrations of them, and Queen Victoria herself wrote of them in her diary (8). It seems only logical to assume that...

Cosmopolitan Space: Political Topographies in ‘Lord Arthur Savile's Crime’

This essay responds to Julian Wolfreys's suggestion that Oscar Wilde's London is primarily psycho-geographical by seeking to read his texts within the historical and spatial context of late nineteenth-century London. Taking as a test the short story ‘Lord Arthur Saville's Crime’, this essay deploys the critical insights of Henri Lefebvre to suggest that Wilde's city writing engages more closely with London life than has been hitherto suggested. Following Lord Arthur on his three perambulations across the city, from Hyde Park and Piccadilly to Covent Garden, through Soho, and finally from St James's to the Embankment, the article focuses particularly on the ways in which Wilde's use of what might easily be assumed to be an incidental location, namely Cleopatra's Needle, invites us to reread the text's revolutionary politics within the context of the French Revolution. Concluding with a discussion of Wilde's treatment of London's ‘cosmopolitan space’, the essay shows that the way in which seemingly stock imagery deployed in Wilde's representation of the city may in fact be read as part of a wider and complex engagement with both the politics and the aesthetics of space.

Virginia Woolf: A Portrait by Viviane Forrester

Reviewed by: Virginia Woolf: A Portrait by Viviane Forrester Drew Patrick Shannon Viviane Forrester. Virginia Woolf: A Portrait. Trans. Jody Gladding. New York: Columbia UP, 2015. 247 pp. While a biography may be free in some ways to break certain narrative rules—one can always begin with the subject's death, for instance—in general it must follow a chronology, introduce its subject to readers unfamiliar with the material, and situate its subject in a historical context. Such rules may not apply to literary portraiture, a form that can show its subject at skewed angles, in odd colors, and with clearly visible brushstrokes. The late Viviane Forrester has produced something much in the latter vein in Virginia Woolf: A Portrait. First published in France, it won the 2009 Goncourt Prize for biography and appears now in an English translation by Jody Gladding. Based almost entirely on primary sources, the book assumes a certain degree of knowledge of Virginia Woolf on the reader's part and proposes to delve deeply into Woolf's psyche to rescue her from what Forrester sees as the unsavory influences of the people who surrounded her. But, as with any portrait, the book reveals perhaps more about its author than its subject. Arranged in five parts, Forrester's book argues for the concept of Virginia "alone" and aims to present her as a gallant, misunderstood figure in need of a much more focused depiction (3). But then Forrester somewhat oddly examines Woolf in light of the major figures and events in her life: her husband Leonard; her family and her childhood in Hyde Park Gate, Kensington; her sister Vanessa Bell; the other members of the Bloomsbury Group and the writers Katherine Mansfield and Vita Sackville-West; and, finally, death itself. Forrester's writing attempts to follow the model set by Woolf in some of the autobiographical writings that appear in Moments of Being as well as the witty, urbane, conversational tone set by Woolf in her best essays and in A Room of One's Own. There are many rhetorical questions scattered throughout the text, most of which ask the reader to ponder how Woolf herself fits into the swirling mix of personalities and often unpleasant events. "What is the weight of a life?" and "What entangled Virginia?" (3), Forrester asks; she provides a running commentary on the length of time it will take before Woolf drowns herself in the River Ouse. While there are moments of elegance—indeed, of poetry—in Forrester's prose, at times the sentences appear clotted and dense and verb tenses often shift from past to present for no discernible reason; sentence fragments and single words stand alone, as if to shock the reader into stillness. One assumes that Gladding reproduced this as accurately as possible from Forrester's original French. The effect, while sometimes beautiful, quickly becomes tiring and cloying. [End Page 597] More problematic than style is Forrester's stance on the other figures in Woolf's life and, ultimately, on Woolf herself. By the fourth page of the book, Forrester launches into an attack on both Leonard Woolf and Quentin Bell; the former is accused of marrying Virginia solely for personal gain (he hated life in colonial Ceylon, and Virginia, requiring much care, could serve as a reason to return to Britain) and the latter is attacked for having produced a two-volume biography of his aunt that simply perpetuated the myths of sexual coldness put forth by Leonard. Bell in particular is attacked relentlessly; he is mentioned over twenty times in the text, typically with condescension if not outright contempt. (Forrester appears to have had issues with Bell since their joint 1973 appearance on a radio program she was producing on—as she puts it—"guess who?" [19].) Troublingly, many of Forrester's arguments about Bell were current in the mid-to late 1970s, and many of the same points were made much more clearly and effectively by Ellen Hawkes Rogat in her 1974 essay "The Virgin in the Bell Biography." Many of Forrester's contentions about Leonard Woolf, Vanessa Bell, Quentin Bell, Leslie and Julia Stephen, the Duckworth brothers and their sexual misconduct, and the other...

A Walled Academic Urban Fortress: Using Neoliberal Urban Policies to Redesign and Maintain Chicago’s Hyde Park Neighborhood

A Walled Academic Urban Fortress: Using Neoliberal Urban Policies to Redesign and Maintain Chicago’s Hyde Park Neighborhood

Everyday Utopias: The Conceptual Life of Promising Spaces

Everyday Utopias: The Conceptual Life of Promising Spaces

Physical Energy Bronze Sculpture at London's Kensington Gardens.

Upon my arrival in London on a fellowship for postdoctoral studies in mid-autumn of 1966, I was provided with accommodation at the British Council Residence at Leinster Gardens, Bayswater. This is midway between the Queensway and Lancaster Gate underground stations, and within short walking distance to Kensington Gardens, which is merged seamlessly with Hyde Park. I have pleasant memories of the many enjoyable strolls in the gardens and views of all kinds of artworks displayed by artists on the outer fences of the park on weekends. On my first …

Parental Behavior Training and Latino/Hispanic Children with ADHD and/or Disruptive Behaviors

Free AccessParental Behavior Training and Latino/Hispanic Children with ADHD and/or Disruptive BehaviorsJosé J. BauermeisterJosé J. BauermeisterFaculty of the Department of Psychology, University of Puerto Rico. He serves on the Advisory Board of the ADHD Report. He can be reached at 177 Las Caobas Street, Hyde Park Urbanization, San Juan, Puerto Rico 00927; E-mail: [email protected]Search for more papers by this authorPublished Online:December 2016https://doi.org/10.1521/adhd.2016.24.8.9PDFPDF PLUS ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations About Previous article Next article FiguresReferencesRelatedDetails Cited byCited by1. Using the Ecological Validity Model to adapt parent-involved interventions for children with Autism Spectrum Disorder in the Latinx community: A conceptual reviewOnline publication date: Go to citation Crossref Google Scholar2. Family Functioning in Latinx Families of Children with ADHD: The Role of Parental Gender and AcculturationOnline publication date: 2 December 2019. Go to citation Crossref Google Scholar3. Family Burden of Raising a Child with ADHDOnline publication date: 23 February 2019. Go to citation Crossref Google Scholar Volume 24Issue 8Dec 2016 Information© 2016 The Guilford PressPDF download

First reported case of Haemoglobin-M Hyde Park in a Malay family living in Malaysia.

Haemoglobin (Hb)-M Hyde Park, also known as Hb-M Akita is a rare type of hereditary Hb M due to autosomal dominant mutation of CAC>TAC on codon 92 of β globin gene resulting in the replacement of histidine by tyrosine on β globin chain. This variant Hb has a tendency to form methaemoglobin (metHb). The iron ion in metHb is oxidized to ferric (Fe3+) which is unable to carry oxygen and the patients manifest as cyanosis clinically. A 9-year-old Malay girl was incidentally found to be cyanotic when she presented to a health clinic. Laboratory investigations revealed raised methaemoglobin levels and Hb analysis findings were consistent with Hb-M Hyde Park. β gene sequencing confirmed a point mutation of CAC>TAC on codon 92 in one of the β genes. The family study done on the individuals with cyanosis showed similar findings. A diagnosis of heterozygous Hb-M Hyde Park was made. Patients with this variant Hb usually presented with cyanosis with mild haemolysis and maybe misdiagnosed as congenital heart disease. No further treatment is needed as patients are relatively asymptomatic. Although the disease is harmless in the heterozygous carriers but the offspring of the carriers may suffer severe haemolytic anaemia when the offspring also inherit other β haemoglobinopathies/thalassemia. This can happen due to high prevalence of β thalassemia carrier (3.5-4 %) found in Malaysia. At the time of writing, this is the first case of hereditary Hb-M Hyde Park diagnosed in a Malay family living in Malaysia.

Interpretation of Free-Field Ground Movements Caused by Mechanized Tunnel Construction

AbstractThis paper summarizes greenfield ground movements caused by the construction of twin 7.1-m-diameter tunnels for London’s Crossrail project using earth pressure balance (EPB) tunnel boring machines (TBM). The data include surface deformations from a series of transects in Hyde Park together with subsurface data from one well-instrumented test section. Although far-field ground movements can be well-fitted using established empirical methods or simplified analytical solutions (elastic half-space), nonlinear, inelastic soil behavior is expected to affect measurements close to the tunnel. This paper considers the effects of constitutive behavior on the observed ground movements. Simple [Mohr-Coulomb (M-C)] and more-complex (MIT-S1) soil models are calibrated using results of high-quality laboratory element tests on intact London clay. The models are then used in two-dimensional (2D) numerical simulations in order to optimize three independent cavity-deformation parameters that control the spatial dist...