AbstractSandwich structures have garnered interest as versatile structures for applications in advanced engineering structures. To fabricate sandwich structures, plastics have replaced conventional materials; however, most of these plastics remain in the environment beyond their functional lifespan. This study describes the fabrication of sustainable hybrid sandwich structures with 3D printed poly‐lactic acid (PLA) cores and self‐reinforced polyethylene terephthalate (srPET) face sheets. The mechanical responses of the hybrid sandwich structures with three types of lattice cores, S‐90, S‐45, and S‐V, were compared with those of the parent material sandwich structures after performing bending and impact tests. The face sheet in the hybrid sandwich structure transferred the load to the core without failure. The hybrid sandwich structure containing the S‐90 core exhibited a higher fracture strength (52.4 MPa) and tangent modulus of elasticity (2860 MPa) than those of the other structures. S‐V exhibited the highest fracture strains of 3.3% and 5% for parent material and hybrid sandwich structures, respectively. This study highlights the sandwich structures with excellent mechanical properties for structural applications.Highlights Novel sandwich structures with 3D printed PLA cores are fabricated. Three‐point bending and low‐velocity impact tests are performed. Failure occurred in the core, but the Sr‐PET face sheets did not deform. Hybrid sandwich structures significantly improve mechanical performance.