Nowadays, society has come to a crossroad, and sustainable earth support is in a severe problem. The development has come at a price where natural resources are exceedingly exploited and where deforestation and land-use change has modified the tropical landscape in many areas of the world, including Indonesia. With all the science and technology that humans have developed thus far, the destruction of nature has not stopped. There is a looming challenge for implementing sustainable development. As a country rich in biocultural diversity, Indonesia offers opportunities to find new ways and knowledge of sustainability. As a country with high biological diversity as well as social culture diversity, Indonesian communities have developed much local knowledge for sustainable use of natural resources. Such a diverse natural, as well as social-cultural knowledge, is a very complex phenomenon that can be used as a new model for sustainability sciences. Sustainability sciences is a science about complexity, and its development needs the integration of social, ecological, natural sciences as well as local knowledge that may harbor local wisdom that thus far has not been understood to be of importance. As such, a transdisciplinary approach is needed to enable the birth of sustainability sciences. Sustainability Sciences articulates a new vision of harnessing science and is, thus, an attempt to strengthen the dialogue between science and society. In this regard, society becomes an active player in the development of the sciences. The integration of scientific knowledge with local knowledge can become an important approach to enrich the development of sustainability sciences in the future. This new approach is what we consider as a form of a knowledge co-creation in sustainability. The existence of a “hybrid knowledge” or “blended knowledge”, which integrate local knowledge and scientific knowledge, will become even more important in the future.The International Symposium on Transdisciplinary Approach for Knowledge Co-creation in Sustainability (ISTAKCOS), as the first scientific meeting in Indonesia of its kind, was aimed to explore new ways and new ideas on Sustainability Sciences. Indonesia, with its biocultural diversity offers, has considerable potential to participate actively in the development of sustainability science, namely by striving to create knowledge co-creation through collaborative work between scientists and the local communities. We believe that this symposium has provided an opportunity for scientists and researchers from different disciplines to have insights into the implementation of Transdisciplinary and Sustainability Science in solving the problems of increasingly complex development issues. We hope that we can forge a partnership for the future of sustainability in Indonesia.The symposium was divided into three parts: plenary session, parallel session, and poster exhibition. The plenary session consisted of presentations by international and national keynote and invited speakers. The parallel session contained the papers presentations by participants divided into three different topics: (1) Sociology, Culture, and Knowledge Management, (2) Ecology and Conservation for Sustainability, (3) Basic Science, Economy and Engineering for Sustainability Sciences. Exhibition activities displayed posters from selected participants who took apart on poster session. The keynote and invited speakers presented at this conference were listed below.List of Scientific Committee, Conference Chair, Editorial Committee and Assistant Editors are available in this PDF.