Over the past decades, it has been widely shown that Low Salinity Waterflooding (LSW) outperformed High Salinity Waterflooding (HSW) in terms of higher oil recovery, particularly in combining with other conventional Enhanced Oil Recovery (EOR) methods such as chemical flooding to benefit from their synergies. This paper presents a novel approach to mechanistically model Hybrid Low Salinity Chemical Flooding, with: (1) development of a hybrid EOR concept from past decades; (2) utilizing a Multilayer Neural Network (ML-NN) artificial intelligent technique in a robust Equation-of-State reservoir simulator fully coupled with geochemistry; (3) systematic validation with laboratory data; and (4) uncertainty assessment of the LSW process at the field scale.Various parameters such as polymer, surfactant, and salinity can affect on the relative permeability simultaneously during hybrid recovery processes. To overcome this problem, the ML-NN technique was applied for multidimensional interpolation of the relative permeability. Additionally, ML-NN was used within a Bayesian workflow to capture the uncertainties in both history matching and forecasting stages of LSW at field scale. The proposed model indicated good agreements with various coreflooding experiments including HSW, LSW, and Low Salinity Surfactant flooding (LSS), where it can efficiently capture the complex geochemistry, wettability alteration, microemulsion phase behavior, and the synergies occurring in these hybrid processes.