Repetitive changes in Early Pliocene marine and continental sediments were forced by astronomical cycles (eccentricity, precession) and related to low amplitude climatic fluctuations as demonstrated at Capo Rossello and Monte San Nicola (Sicily). This work aims to establish if such climatic fluctuations have also controlled changes in the vegetation during the warm Early Pliocene. High-resolution pollen analysis of the Lupoaia section (SW Romania) provides evidence of a clear response owing to its location within a delta system which constitutes a reliable area for pollen deposition near the Carpathians (i.e. capable of registering all the vegetation ecosystems from edaphic coastal associations up to the highest altitudinal belts), and owing to its Southeastern European longitude probably where warm–humid air masses arrived regularly, making the region a highly favourable refuge for thermophilous plants. Eccentricity appears to have controlled fluctuations in temperature (development of thermophilous elements during eccentricity minima, and descent of altitudinal trees during eccentricity maxima) while precession appears to have forced changes in humidity (expansion of cypress swamps related to precession maxima, and spread of herbaceous marshes requiring more humidity related to precession minima) with respect to increased precipitation and run-off.