Background: The incidence of nonunion of humerus has been as high as 15% of all humeral fractures. Majority of humeral shaft fractures were treated by conservative treatment using splints, hanging arm cast, braces compromising anatomical reduction in view of wide range of movement of shoulder and elbow joint. Methods: The prospective study was conducted at Dept. of Ortho-Surgery, Sheikh Sayera Khatun Medical College & Hospital, Gopalgonj, Bangladesh from January 2021 to June 2022. Total 20 patients with fracture shaft humerus, who were treated with locking compression plate from the period were study. All patients are admitted and subjected to clinical & radiological examination, necessary lab investigations are carried out for proposed surgery. Regular follow up will be carried out by clinical examination and with X-rays at interval of 6 weeks, 3 months than 6 months and study will be conducted on a minimum of 20 patients. Results: Total 20 patients with fracture shaft humerus, who were treated with locking compression plate from the period of study. The age group of the patients in our study ranged from 15 years to 65 years. Most of the patients belong to 21- 40 years. 65% with male predominance (70%), with type A3 as the commonest fracture (50%) involving the mid shaft (70%) of humerus, underwent open reduction and internal fixation using locking compression plate. Conclusion: The age of the patient ranged from 15 years to 65. Majority of the patients were males. (M: F = 14: 6). In our series, left humerus was involved in 50% cases, while right was involved in the other 50% of cases.