The paper presents the results of analyzing the influence of major factors for globalization on the clinical and epidemiological manifestations of communicable diseases. Globalization is shown to considerably change the essence of an epidemic process and to affect its all component elements, by substantially accelerating the emergence and prevalence of communicable diseases. All five major aspects of globalization, such as economic, environmental, political, demographic, and technological ones, are closely related and affect both the prevalence of communicable diseases and the possibility of their prevention, control, and treatment. It is concluded that, by taking into account the global pattern of the threat associated with communicable diseases, a comprehensive approach that, in addition to international law on health care service, comprises the regulations and principles of other branches: international law of human rights, international environmental, commercial, humanitarian, and criminal laws, is the most effective method for counteracting this threat. The political will of states and the mechanism for financing the setting up of global and national infrastructures to follow all determinants of the epidemic process are of great importance in providing epidemiological security.