Problem setting. The quality of cooperation of public authorities with public organizations in the humanitarian sphere is one of the key indicators of the development of relations in the country. It is not necessary to prove that culture and art significantly influence economic and other spheres. Humanitarian policy should promote the free development of Ukrainian culture, the cultures of other ethnic groups living in Ukraine, the achievement of development goals of the state and regions. At the same time, the main vector in the interaction of public authorities with public organizations should be the focus on the real success of Ukraine in carrying out reforms, bringing its activities closer to the standards of the European state. Recent research and publications analysis. Scientists engaged in the study of managerial and humanitarian problems are faced with the task of finding and studying traditional and new system-functional methods and tools, in particular, and considering interaction as cooperation and counteraction, adequacy of decision-making consequences of their implementation in the cultivation of rationalism, pragmatism, practicality. Although humanitarian policy should ensure the formation of a single humanitarian space in the state, at the regional level, too, should pursue its own policy, which would be based on regional characteristics. The quality of this policy is significantly determined by the quality of the interaction of OPV with NGOs and, accordingly, the set of tools for organizing such interaction in certain areas. The analysis of scientific publications shows that various elements of interaction of public authorities with public organizations in the field of humanitarian development of regions have become the subject of research by Ukrainian scientists: I. Artemenko [1], V. Bebyk [2], Y. Goremykina [5], V. Kuybida and S. Vozny [14], O. Mykhailovska [16], L. Usachenko [23], O. Yakubovsky and T. Butyrska [24] and others. The need for interaction of public authorities with public organizations in the field of humanitarian development of the region is emphasized in the State Strategy for Regional Development until 2020 [7], the National Strategy for Civil Society Development in Ukraine for 2016-2020 [17]. Problems and approaches to the humanitarian and other spheres of regional development were investigated by: I. Degtyareva [6], V. Kuybida [13], O. Lebedynska, V. Vakulenko, V. Koltun [15], O. Ishchenko [18] and others. Research of the essence and tools of interaction of public authorities with public organizations in the field of humanitarian development of the region is important, but first of all it is necessary to determine the essence and possible directions of this interaction. The paper objective. Thus, the purpose of the article is to determine the essence and main directions of interaction of public authorities with public organizations in the field of humanitarian development of the region in Ukraine. The paper main body. Initiated in Ukraine, the administrative reform and a number of other reforms are designed to change the outdated system of organization of power and lay the foundation for consolidating a new one, where the interaction of public authorities with civil society organizations is designed to solve the tasks and not only the humanitarian sphere of the region. In general, the main objectives of the interaction of public authorities with non-governmental organizations in the region are the creation of a dynamic, balanced socio-economic, humanitarian development of the region, raising the living standards of the population, ensuring the observance of the state-guaranteed social standards for each citizen, and deepening the processes of market transformation on the basis of efficiency improvement use of the potential of the region, increase of efficiency of administrative decisions, improvement of work of bodies of public authority and gr Omad organizations. At the same time, the main line of cooperation between public authorities and non-governmental organizations in the humanitarian sphere should be targeted cooperation for the creation of a favorable informational and cultural environment that would contribute to the implementation of the best principles of the functioning of a sustainable democratic society. Conclusions of the research. The humanitarian sphere should become the dominant part of the modern interaction between OPV and the GO. Let us not forget the order of the universe accomplished by the Creator: above - spiritual, and then - material. An integral component of the humanitarian development of the region, along with man, society and culture, is the interaction of all its subjects. Therefore, in our opinion, studying the areas of interaction between public authorities and NGOs in the field of humanitarian development of the region will provide an opportunity to more clearly understand and plan the processes taking place in public administration and local self-government in Ukraine. Indeed, the presence of these relations is a prerequisite for the functioning of a democratic state and civil society whose construction has been announced and is being gradually realized in Ukraine. The main directions of interaction between OPVs and NGOs in the humanitarian sphere outlined in this article require a well-thought-out strategy and proper coordination. When planning cooperation, the parties should clearly identify the phases, timeframes, expected effectiveness of the implementation of joint plans and responsible executives by the structure, rights and joint responsibility of public authorities and public organizations. While paying tribute to civic organizations, territorial communities as the central components of the state-building process, it is necessary to determine specifically the structure, rights and responsibilities of public authorities regarding interaction with them, which should be the subject of further research.