The paradigm relevance analysis of digital humanitarianism 2.0 today arouses great interest from all sides, so today, in combination with computer technologies, an original innovative paradigm, aptly named Digital Humanitie, appeared. Central to this combination is the connection between the humanities and digital or computer technologies. The computer technology use in their research is nothing new for researchers in the humanities or social sciences. Today, the changes brought about in the teaching of the humanities by new communication technologies, including web-based media forms, technology, digital archives, social networks, mixed realities, and cloud computing, are so vast in scale and reach that they can be measured by comparison with the print revolution. The purpose of the research is a systematic philosophical problematic analysis of scientific knowledge in digital humanities 2.0 paradigm. The aim is to move beyond these critical positions and understand the nature of the relationship between the humanities and the digital. The research is based on the hypothesis that digital humanities are approaches to knowledge that build theories, which are aimed at explaining and understanding the complexity of certain semiotic objects, which help to implement “digital” processing of semiotic objects. We hope to show that HNs unfold in a context between the scientific approach of pragmatic influence and the scientific approach of hermeneutic influence related to the interpretation required by the semiotic objects of scientific research. Research objectives: 1) to provide a conceptual analysis of “humanism” in an evolution context of humanitarian knowledge; 2) reveal the humanitarian scientific concept and its transdisciplinary nature; 3) characterize the scientific humanity concept: from theory to practice; 4) to investigate the applied role of digital humanitarianism in the new scientific paradigm context. – to form a digital city model as a creative sustainable development factor. The basis of the research is the axiological method as a learning value method of digital humanitarianism, the method systemic analysis and synthesis, aimed at uniting the disparate system of knowledge into a single coherent scientific system – theory, Agile methodology method, which analyze principles and approaches system, based on which adaptive human adaptation mechanisms to the “knowledge society”, digital society, which uses the entire digital humanitarianism system to learn objective reality. The richness and ambiguity of the terms “humanities” and “humanism” make their use both difficult and inevitable. The applied digital humanitarianism value is that it has an applied value, and is often used as a humanitarian mission to help populations that are in a digital inequality or live situation in hard-to-reach regions of the planet, as needing humanitarian assistance in the humanitarian mission context.