Human Urinary Trypsin Inhibitor Research Articles

Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).

Human urinary trypsin inhibitor (UTI) and (4-(2-carboxyethyl) phenyl trans 4-aminoethylcyclohexanecarboxylate hydrochloride (DV-1006) competitively inhibited the human acrosomal proteinase acrosin; Ki values were 1.2 x 10-8 M and 9.4 x 10-7, respectively.

Studies on human urinary trypsin inhibitor 1. Its modification on treatment of urine with acid

A urinary trypsin inhibitor with an estimated molecular weight of 67,000 (UTI-1) was isolated from normal human urine by ammonium sulfate precipitation and gel filtration on Sephadex G-100. When urine was acidified prior to ammonium sulfate precipitation, two new inhibitors (UTI-11 and UTI-111) with molecular weights of 45,000 and 23,000 were obtained. The modification of UTI-1 seemed to be due to a heat-labile enzyme in native urine, since it could be prevented by heating the urine at 100 °C for 15 min. The heat labile enzyme might be a protease which was active under acidic condition, such as uropepsin.

Pancreatic hydrolases and the formation of a myocardial depressant factor in shock.

Pancreatic hydrolases and the formation of a myocardial depressant factor in shock.