Human Risk Research Articles

Ecological and human health risk of heavy metals in Nubui River: a case of rural remote communities

IntroductionThe Nubui River is a primary source of water for drinking purposes and other domestic activities in the rural communities dotted along its riparian zone, with agriculture being the major activity occurring in this important ecotone. The river has become a potential sink for agrochemical residue, including heavy metals, and has apparent aesthetic water quality issues, with associated health consequences. This study, therefore, assessed the health risks of heavy metals within the rural populations in the catchment areas, who have limited sources of improved water supply.MethodsThe concentration of iron (Fe), lead (Pb), cadmium (Cd), mercury (Hg), and zinc (Zn) was assessed on cumulatively 275 water samples, using a Perkin Elmer PINAAcle 900 T atomic absorption spectrophotometer for 11 months. A cross-sectional survey was conducted amongst 338 community members, following field observations on utilisation types, aesthetic appeal, and perceived quality of water from the Nubui River. To determine the potential human and ecological risks of heavy metals, the hazard quotient, chronic daily intake, contamination factor, and health pollution indices of heavy metals were computed. STATA version 16 was used to analyse the survey results.ResultsDescriptive statistics of average concentrations of heavy metals in surface water at all sampling stations showed the pattern Hg < Pb < Cd < Zn < Fe, with relatively low concentrations, between 0.001 and 0.004 mg/L for Hg, 0.0011 and 0.0019 mg/L for Pb, 0.0461 and 0.0739 mg/L for Zn, and 0.2409 and 0.377 mg/L for Fe. The findings, however, showed relatively high cadmium levels between 0.0215 mg/L and 0.0383 mg/L in two of five sampling stations in comparison with the World Health Organisation (WHO) drinking water guideline values in some months. Hazard quotient values indicate that the population is safe from the non-carcinogenic health risks of exposure to heavy metals through oral routes. The contamination factor and heavy metal pollution indices for cadmium exceed recommended guideline values of 1 and 100, respectively. Meanwhile, 73.1% of community members evidently preferred the Nubui River for various domestic activities with 86.1% of them utilising it for drinking purposes. This occurrence results in exposure to associated health risks.

Impacts of credit constraints on adoption of risk management strategies and income of maize farmers in Northern Nigeria

PurposeA correlation has been shown in the literature between credit constraints and the adoption of agricultural technologies, technical efficiencies and measures for adapting to climate change. The relationship between credit constraints, risk management strategy adoption and income, however, is not well understood. Consequently, the purpose of this study was to investigate how credit constraints affect the income and risk management practices adopted by Northern Nigerian maize farmers.Design/methodology/approachCross-sectional data were collected from 300 maize farmers in Northern Nigeria using a multi-stage sampling technique. Descriptive statistics, seemingly unrelated regression and double hurdle regression models were the analysis methods.FindingsThe results showed that friends and relatives, banks, “Adashe”, cooperatives and farmer groups were the main sources of credit in the study area. The findings also revealed that the sources of risk in the study area included production risk, economic risk, financial risk, institutional risk, technological risk and human risk. In addition, the risk management strategies used to mitigate observed risks were fertilizer application, insecticides, planting of disease-resistant varieties, use of herbicides, practising mixed cropping, modern planning, use of management tools as well as making bunds and channels. Furthermore, we found that interest rate, farm size, level of education, gender and marital status were significant determinants of statuses of credit constraints while the age of the farmer, gender, household size, primary occupation, access to extension services and income from maize production affected the choice and intensity of adoption of risk management strategies among the farmers.Research limitations/implicationsThe study concluded that credit constrained status condition of farmers negatively affected the adoption of some risk management strategies and maize farmers’ income.Practical implicationsThe study concluded that credit constrained status condition of farmers negatively affected the adoption of some risk management strategies and maize farmers’ income. It therefore recommends that financial service providers should be engaged to design financial products that are tailored to the needs of smallholder farmers in the study area.Originality/valueThis paper incorporates the role of constraints in influencing farmers’ decisions to uptake credits and subsequently their adoption behaviours on risk management strategies. The researcher approached the topic with a state-of-the-art method which allows for obtaining more reliable results and hence more specific contributions to research and practice.

The Influence of Taste Genes on Body Fat and Alcohol Consumption.

Dietary intake and alcohol consumption might be influenced by genetic variations in taste receptor genes. The objectives of this study were to examine the relationship between polymorphisms in the bitter taste receptor genes TAS2R13 (rs1015443) and TAS2R38 (rs1726866, rs10246939, and rs713598) as well as alcohol consumption and body fat percentage in college students. Four hundred and two students with a mean age of 20.2 years participated in this study. An NIH Diet History Questionnaire (DHQ II) was used to collect data on their dietary intake, while an AUDIT survey was used to determine their level of alcohol consumption. Bitter taste receptor gene polymorphisms were assessed by TaqMan allelic discrimination assays. Despite significant associations between TAS2R13 (rs1015443) and certain aspects of alcohol consumption, including the frequency of alcohol intake, no significant associations were found between TAS2R13 (rs1015443) and alcohol consumption after accounting for confounding variables in the regression model. Neither association was found regarding percent of body fat. In contrast, ethnicity and gender significantly influenced percent of body fat (p < 0.001), while no significant association was observed between TAS2R13 (rs1015443) and percent of body fat. Likewise, TAS2R38 (rs1726866, rs10246939, and rs713598) demonstrated no significant association with alcohol consumption and percent of body fat. These results were controlled for confounding factors, such as ethnicity and gender. Body fat percentage and alcohol consumption may be influenced by ethnicity, gender, and age rather than SNPs of TAS2R13 and TAS2R38 genes. Assessing taste genes' interactions with diet and body composition might be useful in identifying human disease risk.

Economic efficiency of small-scale wheat production in Jigawa state, Nigeria

Africa’s most populous country has failed to grow more food for its fast-rising population. With 420,000 metric tons of wheat produced in Nigeria in 2020, the country is still far from bridging its 4.6 million metric tons annual wheat gap. Increasing wheat production is a challenge for the nation to fulfill the food requirements of its growing population. So far literature has shown a rise in research on wheat in different parts of Nigeria, with a paucity of information on the economic efficiency of wheat production in the study area, and the country in general. To bridge these knowledge and empirical gaps, this research investigates the economic efficiency of wheat production in Jigawa State of Nigeria using information gathered from a survey elicited by a well-structured questionnaire coupled with an interview schedule from 341 active wheat farmers selected through a multi-stage sampling technique. Both descriptive and inferential statistics were used to analyze the data collected. Empirically, despite the wheat enterprise being profitable in the study area, farmers didn’t achieve the targeted goals of output maximization, cost minimization, and profit maximization as evident respectively by the technical, cost, and economic efficiency indexes. However, these goals were challenged by induced human risks viz. gender discrimination that affects women’s access to productive resources, poor labor productivity due to diminishing marginal returns associated with old age, capital consumption triggered by increased income, poor prioritization of wheat enterprise as a business, and vulnerable household size. Furthermore, the identified constraints mediating the links that affected the economic efficiency of wheat farmers were price/marketing, technological, managerial, and infrastructural risks. Therefore, for long-run sustainable wheat production, the responsibility lies on policymakers to concentrate more on marketing and technological risks challenging wheat production in the study area as empirically established by this research.

Differentiation of cellular responses to particulate and soluble constituents in sunscreen products

Despite the growing awareness of potential human and environmental risks associated with sunscreens, identifying the specific constituents responsible for their potential toxicity is challenging. In this study, we applied three different types of sunscreens with contrasting compositions and compared the effects of their particulate and soluble fractions based on 15 cellular biomarkers of HaCaT cells. Multilinear regression analysis revealed that the internalized soluble fractions played a primary role in the overall cytotoxicity of sunscreen mixtures, which was primarily attributed to their biotransformation, generating metabolites with higher toxicity. The presence of plastic microspheres in sunscreens either inhibited the internalization of soluble fractions or led to their redistribution toward lysosomes. Conversely, subcellular toxicity resulting from the sunscreen mixture was predominantly influenced by particulates. Bio-transformable particulates such as ZnO dissolved in the organelles and induced higher subcellular toxicity compared to bioinert particulates such as microplastics. Subcellular biomarkers including lysosomal count, lysosomal size, mitochondrial count and mitochondrial shape emerged as the potential predictors of sunscreen presence. Our study provides important understanding of sunscreen toxicity by elucidating the differential impacts of particulate and soluble fractions in mixture contaminants.

Occurrence of organic ultraviolet absorbers in the particle and gas samples from plastic greenhouses: Human inhalation intake risk assessment

The environmental pollution of organic ultraviolet absorbers (UVAs) has attracted global attention. However, the distribution, sources and risk assessment of UVAs in air from plastic greenhouses are rarely reported. This study was the first to investigate the concentrations of ten UVAs in the air samples from plastic greenhouses. The total concentrations of ten UVAs (∑10UVAs) in the air samples ranged from 5.7 × 103 ng/m3 to 6.3 × 103 ng/m3 (median 5.7 × 103 ng/m3) in greenhouses covered with biodegradable mulch film, 288.2 ng/m3 to 376.4 ng/m3 (median 333.9 ng/m3) in greenhouses covered with PE mulch film, and 97.9 ng/m3 to 142.6 ng/m3 (median 114.9 ng/m3) in greenhouses covered without mulch film. The concentrations of ten UVAs in 65 commercial agricultural films were simultaneously analyzed. Additionally, the potential health risks for greenhouse workers exposed to UVAs were estimated. And the migration simulations showed that the health risk in greenhouses may be higher even if only one UVA is added to the biodegradable mulch film. Therefore, the exposure risk of UVAs in plastic greenhouses needs to be highly prioritized.

Occurrence and distribution of pesticides and transformation products in ambient air in two European agricultural areas

Pesticides present a significant risk for both humans and the environment. However, quantitative data for a broad range of airborne pesticides in agricultural areas are missing. During or after the application, pesticides can reach the atmosphere and partition between the particulate and gaseous phase. As part of the EU project SPRINT, weekly ambient air samples were collected from two agricultural areas in Portugal (vineyard) and the Netherlands (potatoes, onions, and sugarbeet) between April 2021 and June 2022 using high-volume air samplers. The samples were analysed for 329 pesticides, of which 99 were detected. The most frequently detected compounds included the fungicides folpet, fenpropidin and mandipropamid, the insecticide chlorpyrifos-methyl, the herbicide terbuthylazine, and the metabolite prothioconazole-desthio, which were found with detection frequencies between 40 and 57 %. Pesticide concentrations ranged between 0.003 ng/m3 and 10 ng/m3. Remarkably, 97 % of the samples contained at least one pesticide and in 95 % of the samples, pesticide mixtures were present. The calculated particle phase fractions correlated with the octanol-air partitioning coefficient for most of the investigated compounds. Furthermore, calculated daily inhalation rates for individual pesticides and pesticide mixtures were far below the Acceptable Daily Intake (ADI) with a margin of exposure (MOE) of >1000 for the highest calculated daily inhalation rate for a child. However, as this value only includes pesticide intake from food and drinking water and considering that 91 % of the detected pesticides are associated with potential adverse human health effects. These findings highlight the broad range of airborne pesticides in agricultural areas and the need for quantitative data to include the intake of mixtures of highly hazardous pesticides by inhalation in human risk assessment.

Current and future environmental suitability for bats hosting potential zoonotic pathogens in rural Kenya.

Synanthropic bats live in close proximity to humans and domestic animals, creating opportunities for potential pathogen spillover. We explored environmental correlates of occurrence for a widely distributed synanthropic African bat, Mops pumilus-a species associated with potential zoonotic viruses-and estimated current and future environmental suitability in the Taita Hills region and surrounding plains in Taita-Taveta County in southeast Kenya. To project future environmental suitability, we used four Coupled Model Intercomparison Project Phase 6 general circulation models that capture temperature and precipitation changes for East Africa. The models were parameterized with empirical capture data of M. pumilus collected from 2016 to 2023, combined with satellite-based vegetation, topographic, and climatic data to identify responses to environmental factors. The strongest drivers for current environmental suitability for M. pumilus were short distance to rivers, higher precipitation during the driest months, sparse vegetation-often related to urban areas-and low yearly temperature variation. To predict current and future areas suitable for M. pumilus, we created ensemble niche models, which yielded excellent predictive accuracies. Current suitable environments were located southward from the central and southern Taita Hills and surrounding plains, overlapping with urban centers with the highest human population densities in the area. Future projections for 2050 indicated a moderate increase in suitability range in the southern portion of the region and surrounding plains in human-dominated areas; however, projections for 2090 showed a slight contraction of environmental suitability for M. pumilus, potentially due to the negative impact of increased temperatures. These results show how environmental changes are likely to impact the human exposure risk of bat-borne pathogens and could help public health officials develop strategies to prevent these risks in Taita-Taveta County, Kenya, and other parts of Africa.

A survey in Liangshan, Sichuan showed higher human papillomavirus infection rate and cervical cancer risk for Yi Chinese compared to Han Chinese

A survey in Liangshan, Sichuan showed higher human papillomavirus infection rate and cervical cancer risk for Yi Chinese compared to Han Chinese

Effects of wind-induced vibrations in tall buildings on human balance and risk of falls

Effects of wind-induced vibrations in tall buildings on human balance and risk of falls

Temperature-related Saccharification of Delignified Sawdust Materials from the Lagos Lagoon in Nigeria

Sawdust, a product of the forest industry is mostly left untreated as solid waste. This phenomenon is well observed along the Lagos Lagoon in Nigeria where hundreds of trees are cut daily by sawmills to deliver wood for mainly the furniture industry. Different types of trees are utilized in this manner and the massive amounts of sawdust produced as a result of these activities are polluting the environment causing health risks for humans and animals. Cellulose, a glucose bio-polymer is a major structural component of sawdust and could be developed as a renewable energy resource should the cellulose be degraded into glucose, a fermentable sugar. This saccharification was done with Aspergillus niger cellulase and to make the cellulose more susceptible for cellulase action the sawdust was delignified with hydrogen peroxide. Both delignified and non-delignified sawdust were treated with the cellulase enzyme at incubation temperatures of 30°C, 40°C, 50°C, and 60°C. Delignification proved to be effective as an increased amount of sugar was released from all delignified sawdust materials relative to the non-delignified materials when saccharified with A. niger cellulase. Most of the materials were degraded at an incubation temperature of 40°C and 50°C and the highest percentage saccharification of 58% was obtained during the degradation of delignifed cellulose from the tree, Ricindendron heudelotti

Preserving Tell Atrib: Analysing Human Risks and Applying Protective Measures

Preserving Tell Atrib: Analysing Human Risks and Applying Protective Measures

Unveiling human vulnerability and a new interspecies scaling law for brain injury under blast loading

The common belief that animals with larger heads are more tolerated to brain injury faces challenges under the extreme conditions of blast loading. Recent studies indicate that humans, who have notably larger heads than other species of similar body weight, exhibit a unique vulnerability. Integrating animal experimental data, advanced head modeling, and pressure propagation theories, this research elucidates the injury mechanisms across species as the blast wave transitions from the extremely hard skull to the extremely soft brain. We propose a new interspecies scaling law based on consistent peaks of intracranial pressure, rather than head size, to redefine the translation from animal exposure thresholds to human risk assessment. This shift in perspective underscores the imperative to comprehensively consider both head geometry and size in predicting tolerance to blast brain injury, moving beyond simplistic size-based comparisons. Our study's insights contribute significantly to redefining injury risk models and fostering innovative prevention strategies against blast-induced traumatic brain injury (bTBI).

Hepatotoxicity of silver nanoparticles: Benchmark concentration modeling of an in vitro transcriptomics study in human iPSC-derived hepatocytes

Despite two decades of research on silver nanoparticle (AgNP) toxicity, a safe threshold for exposure has not yet been established, albeit being critically needed for risk assessment and regulatory decision-making. Traditionally, a point-of-departure (PoD) value is derived from dose response of apical endpoints in animal studies using either the no-observed-adverse-effect level (NOAEL) approach, or benchmark dose (BMD) modeling. To develop new approach methodologies (NAMs) to inform human risk assessment of AgNPs, we conducted a concentration response modeling of the transcriptomic changes in hepatocytes derived from human induced pluripotent stem cells (iPSCs) after being exposed to a wide range concentration (0.01–25 μg/ml) of AgNPs for 24 h. A plausible transcriptomic PoD of 0.21 μg/ml was derived for a pathway related to the mode-of-action (MOA) of AgNPs, and a more conservative PoD of 0.10 μg/ml for a gene ontology (GO) term not apparently associated with the MOA of AgNPs. A reference dose (RfD) could be calculated from either of the PoDs as a safe threshold for AgNP exposure. The current study illustrates the usefulness of in vitro transcriptomic concentration response study using human cells as a NAM for toxicity study of chemicals that lack adequate toxicity data to inform human risk assessment.

Recycling of printed Xerographic paper using Aspergillus assiutensis enzyme cocktail: an integrated approach to sustainable development.

To overcome the human and animal survivability risk, sustainable development is the only option on earth that can be achieved through the maximum use of renewable environmental resources. Recycling of waste paper is an emerging waste management approach to conserve natural resources. Herein, we studied enzyme-mediated process to recycle the xerographic paper by using the crude fungal extract from indigenously isolated fungi identified asAspergillus assiutensis. The fungal enzyme cocktail has been characterized for the production of multiple enzymes namely cellulase, amylase, xylanase, pectinase, and protease. All these enzymes have pH optima in the acidic range and except cellulase and all the enzymes are stable from 10 to 80C. In the zymogram analysis, pectinase, xylanase, amylase, and cellulase were detected at 68kDa, ~ 54kDa, 38kDa, and 30kDa, respectively. Also, the presence of protease was confirmed by the clear zone at 68, 31, and 16kDa. A 26% decrease in the kappa number and reduction in Hex A of the pulp was observed on the treatment of the pulp with enzyme as compared to the control pulp without any treatment. The physical and chemical properties of the pulp were also improved by enzyme-mediated pulping as compared to the control The physiochemical parameter of the effluent like TDS was reduced (397ppm) significantly in comparison to chemical deinking process and it was within the permissible limit. BOD and alkalinity were reduced when the enzymes and chemical dosage were used in combination. These results indicate that chemi-enzymatic deinking is most promising to reduce or remove the pollution parameters including ink and this approach can be used in the paper and pulp industry for sustainable development.

Geochemical Signature and Risk Assessment of Potential Toxic Elements in Intensively Cultivated Soils of South-West Punjab, India

Soil contamination with potentially toxic elements (PTEs) in the Malwa region belt of Punjab, India, can be a serious concern as a result of intensive agricultural practices and overuse of agrochemicals. The main objectives of the present study were to evaluate the spatial distribution, geochemical signature, and contamination level/health risk of PTEs in 76 soil samples (0–10 cm) collected from the three districts viz. Muktar, Faridkot, and Moga of Punjab, India. The result shows that PTEs concentrations vary widely in the region, with Fe and Mn distribution patterns being mostly coherent with each other. When compared to the Indian natural soil background values, the average concentration of Pb and Zn were higher than the limit, only Pb exceeded the average values of the world background and upper continental crust (UCC). Spatial autocorrelation plotted with a local indicator of spatial association (LISA) in GeoDa software version 1.18 was used to identify hotspots. A positive spatial autocorrelation (&gt;0.2) was indicated with Moran’s I values for Pb, V, Mn, Cu, and Cr, being highest for Pb. A principal component analysis (PCA) identified the major geo-chemical patterns of Fe-Al-V-Cr and TOC-Mn-Zn-HCO3−, which were positively loaded on PC1. This indicates that Fe/Al-oxyhydroxides and organic matter play a dominant role in controlling metal mobility in soils. This can be further substantiated with the Spearman’s rank correlation values. The contamination factor (CF) indicates that only Pb and Zn (15.7% and 3.9% samples, respectively) were under high risk. This could be due to the excessive application of chemical fertilizers. The large range of degree of contamination (Cdeg) values suggests that there are variations in the degree of soil pollution due to PTEs. A little over 3.9% of samples had significant contamination, compared to 72.3% of samples with low contamination and 23.6% of samples with moderate contamination. Human non-carcinogenic and carcinogenic risk levels were investigated. The hazard index (HI) values for adult ranged from 0.00 to 0.2, and values for children ranged from 0.009 to 1.2. These findings suggest that both children and adults are not at potential risk, except in a few locations. Overall, the results of this study provide the current baseline status of toxic elements in agricultural soil. This would be helpful for developing strategies for sustainable management of the soil resources in the region, as well as for future monitoring programs of the soil quality in the Malwa region as a whole, to track any changes in the contamination levels over time.

Observer 8: Outliers, Attention, and Situated Knowledge in a Qualitative Behavioral Assessment of Laboratory Mouse Welfare

This article explores how an innovative animal welfare methodology (Qualitative Behavior Assessment) negotiates subjectivism and objectivism in its distinctive epistemology, as it strives to produce a certain kind of laboratory mouse—a complex, social subject. Through an ethnographic study of the development of a Qualitative Behavior Assessment (QBA) tool for laboratory mouse welfare, I show how QBA foregrounds the animal’s lived emotional experience by using qualitative language to assess their welfare, while also relying on statistical methods of validation. Drawing on Mol et al.’s understanding of care as something that parses, handles, and balances diverse “goods,” I argue that QBA practitioners’ care for the data must balance competing priorities and values. I take particular interest in what makes a “good” assessor as they transform between subject and object. When two observers are found to be outliers, with their divergent judgments marring the successful statistical validation of the QBA mouse tool, the situated nature of knowledge is brought to the fore. I argue that turning to the embodied practice of attention, as distinct from care, helps us understand why, and raises questions about the epistemic culture of conventional animal welfare science and the extent to which the human observer risks reification within QBA’s formal methodological practice.

Quantitative tracing the sources and human risk assessment of complex soil pollution in an industrial park

Pollution in industrial parks has long been characterized by complex pollution sources and difficulties in identifying pollutant origins. This study focuses on a typical industrial park consisting of 11 factories (F1–F11) including organic pigment, inorganic pigment, and chemical factories in Hunan Province, China, here, a total of 327 sample points were surveyed. Eight pollutants (Mn, Cd, As, Co, NH3–N, l, 1,2-Trichloroethane, chlorobenzene, and petroleum hydrocarbons) were classified as contaminants of concern (COCs). This study assessed the contributions of driving factors to the distribution of COCs in the soil. Pollutant source apportionment was conducted using positive matrix factorization (PMF) and random forest (RF). The results revealed that the main factors driving pollution are groundwater migration, non-compliant emissions, leaks during production, and interactions among pollutants. The primary pollution sources were four chemical factories and an inorganic pigment factory. Source 5 demonstrates significant correlations with TCA (29.6%), CB (30%), and As (31.6%). Two chemical factories (F7 and F10) are the most significant pollution source with a risk assessment contribution rate of more than 60%. The present study sheds some light on the contamination characteristics, source apportionment and source-health risk assessment of COCs in industrial park. By utilizing the proposed research framework, decision-makers can effectively prioritize and address identified pollution sources.

The effect of different types of microplastic and acute cadmium exposure on the Mytilus galloprovincialis (Lamarck, 1819)

Microplastic (MP) pollution is a pressing issue for both environmental health and the safety of human food sources. This study provides a comprehensive analysis of the effects of MPs on Mediterranean mussels (Mytilus galloprovincialis, Lamarck 1819), focusing on the food safety risks associated with MP and cadmium (Cd) exposure in these organisms intended for consumption. The retention of different polymer types of MPs in mussels was specifically evaluated, and the influence of Cd on MP retention across these polymers was investigated. Mussels were exposed to polystyrene (PS), polypropylene (PP), and polyethylene terephthalate (PET) MPs individually and in combination with the toxic metal Cd for a duration of 7 days. Antioxidant enzymes, oxidative stress parameters, and digestive system enzyme activities, selected as biomarkers for Cd and MPs pollution, were assessed. Furthermore, human consumption risk evaluations and limits regarding mussel intake were analysed in terms of food safety. The results suggest that exposure to Cd, MPs, or their combination induces oxidative stress, tissue damage, and neurotoxicity. Alterations in digestive enzyme activities could impact the mussels' energy acquisition from food and their capacity to conserve energy reserves. The estimated daily intake (EDI), provisional tolerable weekly intake (PTWI), target hazard quotient (THQ), and target cancer risk (TCR) levels for all groups surpassed established limits, implying a significant health risk for humans consuming these products. These results underscore the potential health risks for humans associated with consuming mussels exposed to Cd and/or MPs and provide valuable data for monitoring pollution levels and ecological risks in aquatic organisms. Additionally, our findings reveal that the retention of Cd in mussel tissues varies significantly after exposure, with combinations of PET and Cd showing lower levels of Cd accumulation compared to other groups, suggesting a differential interaction that influences Cd retention.

Human and ecological risk assessments of potentially toxic elements in sediments around a pharmaceutical industry

Potentially toxic elements (PTEs) in sediment can be highly hazardous to the environment and public health. This study aimed to assess the human and ecological risks of PTEs in sediments around a pharmaceutical industry in Ilorin, Nigeria. Physicochemical parameters and the concentrations of lead (Pb), chromium (Cr), cadmium (Cd), cobalt (Co), arsenic (As), and nickel (Ni) were analyzed in sediment samples collected from seven locations in the wet and dry seasons. Standard two-dimensional principal component analysis (PCA) and risk assessments were also conducted. The concentrations of Pb, Co, Ni, Cr, Cd, and As in the sediments ranged from 0.001 to 0.031 mg/kg, 0–0.005 mg/kg, 0.005–0.012 mg/kg, 0.001–0.014 mg/kg, 0.005–0.024 mg/kg, and 0.001–0.012 mg/kg, respectively. The mean concentrations of the total PTEs content were found in decreasing order of concentration: Pb > Cd > Ni > Cr > As > Co. PCA showed that some of the PTEs were highly concentrated in samples obtained at other locations as well as at the discharge point. The Hazard Index was mostly <1 across locations, indicating little to no probable non-cancerous effect. However, the incremental lifetime cancer risk for arsenic and nickel was high and required attention. The ecological risk assessment showed that lead and arsenic were the major PTEs pollutants in all locations. The study identifies PTEs profiles in sediments and emphasises the necessity of continual monitoring and action to stop long-term negative impacts on the local environment and public health.