Abstract: This article revisits the classic Needham question by reassessing its heuristic value, analytical pitfalls, and historiographical significance. It also examines the definition, logic (internal and external), and modernity of science before providing a macro-comparative view of its early modern development at both ends of Eurasia. This article advocates a more eclectic approach to the history of techno-science that combines different sets of seemingly dichotomous variables with the aim of explaining its diversified change in different spatial-temporal contexts. It concludes by calling attention to the enigma of China’s techno-scientific resurgence over the past several decades, which constitutes a modern sequel to the Needham puzzle that foregrounds its growing contemporary, futuristic, and global relevance. Needham’s powerful narrative on cross-cultural dialog, earnest desire to fuse Eastern and Western science as well as optimistic vision of human progress are the most important intellectual legacy of his pioneering work.