Human Placentation Research Articles

Morphopathology of the human placental villi and the fetal outcome. (A study by phase-contrast microscopy).

Morphopathology of the human placental villi and the fetal outcome. (A study by phase-contrast microscopy).

Insulin output via the pancreatic vein and plasma insulin response to glucose in dogs.

ARTICLESInsulin output via the pancreatic vein and plasma insulin response to glucose in dogsY Kanazawa, T Kuzuya, and T IdeY Kanazawa, T Kuzuya, and T IdePublished Online:01 Sep 1968https://doi.org/10.1152/ajplegacy.1968.215.3.620MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByThe Complex Exocrine–Endocrine Relationship and Secondary Diabetes in Exocrine Pancreatic DisordersJournal of Clinical Gastroenterology, Vol. 45, No. 10Pulsatile insulin secretion accounts for 70% of total insulin secretion during fastingN. Porksen, S. Munn, J. Steers, S. Vore, J. Veldhuis, and P. Butler1 September 1995 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 269, No. 3The islet-acinar axis of the pancreasInternational journal of pancreatology, Vol. 16, No. 2-3Potentiating effect of insulin on exocrine secretory function in isolated rat pancreatic aciniGastroenterology, Vol. 106, No. 1Effect of Insulin on Hepatic Bile Secretion during Normoglycaemia and Hyperglycaemia8 July 2009 | Scandinavian Journal of Gastroenterology, Vol. 26, No. 6Selective in situ pancreatic perfusion via chronic in vivo celiac artery catheterizationMetabolism, Vol. 36, No. 9Blood flow measurement in the canine pancreasJournal of Surgical Research, Vol. 42, No. 1Pharmacokinetics of insulin following intravenous and subcutaneous administration in caninesBiopharmaceutics & Drug Disposition, Vol. 7, No. 5The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dogDiabetologia, Vol. 29, No. 7New Methods for the Analysis of Insulin Kinetics in Vivo: Insulin Secretion, Degradation, Systemic Dynamics and Hepatic ExtractionPrimary cultures of rat pancreatic acinar cells in serum-free mediumIn Vitro Cellular & Developmental Biology, Vol. 21, No. 1Net insulin secretion and IRI response to 1 mg glucose during OGTTResearch in Experimental Medicine, Vol. 179, No. 3Hepatotrophic effects of insulin on glucose, glycogen, and adenine nucleotides in hepatocytes isolated from fasted adult ratsGastroenterology, Vol. 78, No. 3Insulin receptors in isolated mouse pancreatic aciniBiochemical and Biophysical Research Communications, Vol. 84, No. 2Insulin kinetics in metasomatotropic diabetesMetabolism, Vol. 27, No. 1Influence of blood glucose levels on serum concentrations of pregnancy-specific protein SP-1 and HPL during the last trimester of pregnancyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 6, No. 2Estimation of pancreatic IRI output rate and its relation to glucose tolerance in normal anaesthetized dogsDiabetologia, Vol. 11, No. 4Die Sekretion des Insulins. Stimulierung und HemmungDynamics of canine pancreatic blood flow and of insulin secretion during an intravenous glucose loadPfl�gers Archiv European Journal of Physiology, Vol. 358, No. 1The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) miceDiabetologia, Vol. 10, No. 4GLUCOSE-INSULIN INTERACTION AND THE MODULATION OF HUMAN PLACENTAL LACTOGEN (HPL) SECRETION DURING PREGNANCYBJOG: An International Journal of Obstetrics and Gynaecology, Vol. 81, No. 3Pancreatic islet cell membranes: Extraction of a possible glucoreceptorBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 318, No. 3Effect of vasopressin on pancreatic blood flow in acute hemorrhagic pancreatitisThe American Journal of Surgery, Vol. 123, No. 2Segmental venous drainage of the canine pancreasJournal of Surgical Research, Vol. 11, No. 11Glucose Intolerance in Nonischemic Cardiac DiseaseCirculation, Vol. 43, No. 6The Effect of Glucose and Insulin on Pancreatic Blood Flow in the Anesthetized Pig8 July 2009 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 27, No. 2Die Dauerkatheterisierung der Vena cava caudalis und Vena portae beim Schaf zur Messung der circadianen Insulinausschüttung und der Insulinausschüttung nach Glukosebelastung I. Mitteilung13 May 2010 | Zentralblatt für Veterinärmedizin Reihe A, Vol. 17, No. 8The effects of caerulein on insulin secretion in anaesthetized dogs19 July 2012 | British Journal of Pharmacology, Vol. 40, No. 1 More from this issue > Volume 215Issue 3September 1968Pages 620-626 Copyright & PermissionsCopyright © 1968 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1968.215.3.620PubMed4876421History Published online 1 September 1968 Published in print 1 September 1968 Metrics

Immunological factors in human placentation.

A CONSIDERABLE volume of evidence from animal experiments suggests that mammalian placentation is under some kind of immunological control. In the mouse, for example, it has been shown that placental size1,2 and, indirectly, foetal size and length of gestation3 can be influenced by the materno-foetal immunological relationship. An increase in placental weight with birth order has been described in several species (mouse4, rat5, guinea-pig6 and man7,8) and this may represent an immunological effect.

KINETIC STUDY OF THE AROMATIZATION OF TESTOSTERONE AND ANDROSTENEDIONE BY HUMAN PLACENTAL MICROSOMES

Journal Article KINETIC STUDY OF THE AROMATIZATION OF TESTOSTERONE AND ANDROSTENEDIONE BY HUMAN PLACENTAL MICROSOMES Supported by grants from the USPHS and The American Cancer Society, Inc. Get access E Menini, E Menini The John Collins Warren Laboratories of the Huntington Memorial Hospital of Harvard University, at the Massachusetts General Hospital, Boston, Massachusetts, U.S.A.Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar L L Engel L L Engel The John Collins Warren Laboratories of the Huntington Memorial Hospital of Harvard University, at the Massachusetts General Hospital, Boston, Massachusetts, U.S.A.Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Acta Endocrinologica (Norway), Volume 56, Issue 1_Supplement, Dec 1967, Page S76, https://doi.org/10.1530/acta.0.056S076 Published: 01 December 1967

Derivation and ultrastructure of the so-called Hofbauer cell

The derivation and significance of the so-called Hofbauer cells were studied by analysis of sex chromatin, histochemistry, and electron microscopy, in an attempt to ascertain their immunologic and metabolic significance, if any, in human placentation. Ultrastructurally, the Hofbauer cell is characterized by vacuolar cytoplasm and scant ergastoplasmic fragments, but well-developed endoplasmic reticulum and Golgi complexes are absent. Various stages of degeneration are normally found. Although the ordinary Hofbauer cell may be distinguished by histochemistry and electron microscopy from the typical fibroblast and plasma cell, transitional and poorly differentiated forms are commonly found, exemplifying the variety and interconversion of villous mesenchymal elements. The Hofbauer cell is not a specific entity with regard to either origin or function, but rather a villous stromal component arising by differentiation or degeneration of other mesenchymal elements; since, furthermore, it may differentiate in situ from the villous mesenchyme throughout pregnancy, it provides little aid in diagnosis of placental abnormalities.

A preliminary note upon the question of the nutrition of the early embryo, with special reference to the guinea-pig and man

During the progress of a research into the earliest implantation of the embryo of the guinea-pig, I have been particularly struck with the way in which the nutrition of the embryo is anticipated and provided for during the time it remains free in the uterine horn. The so-called yolk-granules of the ovum are obviously insufficient to provide for the growth of the embryo to the stage prior to differentiation of the inner cell-mass, to which it attains during the five or six days which elapse before it comes into contact with the maternal tissues. It is clear that it must derive nourishment from the medium in which it lies―the product of the secretion of the uterine or other glands, which, during the period of pro-œstrum, exhibit such marked activity. I suggest that this secretion, which consists of mucus and probably albumin, is assimilated by the embryo after having undergone a process of digestion, the result of a secretory activity on the part of the outermost cells of the embryo―the cells of the Trophoblast. This suggestion I base on my observations in the guinea-pig, where I am able to demonstrate a breaking-down of maternal cells before the Trophoblastic cells are in actual contact; likewise in human placentation where a more or less dense layer of fibrin and broken-down leucocytes and decidual cells, the result of Trophoblastic activity, affords a barrier interposed between the invading Trophoblastic cells and the Decidua. This layer I purpose naming the “Protective Layer.” Looked at from a comparative point of view, there is in all probability a close analogy between the uterine secretion of mammals, and the secretion of the oviducts of the lower vertebrata. In the case of birds the analogy is very striking, on account of the direct and important share in the nutrition of the embryo afforded by this secretion, commonly known as the white of the egg. In the case of the frog the ovum receives in its passage down the oviduct, corresponding to the uterine horn of the guinea-pig, a coating of mucus and probably albumin, comparable to the uterine secretion referred to above; when it reaches the water and becomes fertilised, this swells up by absorption, forming a gelatinous covering. The embryo for nutriment depends upon the yolk contained in the ovum before fertilisation, upon the covering of mucus and probably albumin, and lastly upon the water in which it lies. In certain mammals, as, for example, the rabbit and the mole, a distinct gelatinous envelope is described as surrounding the embryo before implantation occurs; this envelope is, I suggest, possibly due to some digestive action of the cells of the Trophoblast upon the adjacent medium, producing a form of coagulation.

Recent Literature Human Placentation . An Account of the Changes in the Uterine Mucosa, and in the Attached Fetal Structures During Pregnancy. By J. Clarence Webster, B.A., M.D. (Edin.), F.R. C.P.E., F.R.S.E., Professor of Obstetrics and Gynecology in Rush Medical College. pp. 185, with 233 illustrations. Chicago: W. T. Keene & Co. 1901.

Recent Literature Human Placentation . An Account of the Changes in the Uterine Mucosa, and in the Attached Fetal Structures During Pregnancy. By J. Clarence Webster, B.A., M.D. (Edin.), F.R. C.P.E., F.R.S.E., Professor of Obstetrics and Gynecology in Rush Medical College. pp. 185, with 233 illustrations. Chicago: W. T. Keene & Co. 1901.

Human Placentation.—An account of the changes in the Uterine Mucosa and in the Attached Fetal Structures during Pregnancy.

Human Placentation.—An account of the changes in the Uterine Mucosa and in the Attached Fetal Structures during Pregnancy.