Based on IoT technology, it can combine the actual needs of the university laboratory system to establish an equipment safety monitoring system, share data in real time, and monitor the operation equipment of university laboratories comprehensively. Through the collection of equipment-related data, we have a comprehensive analysis of data in order to have an accurate judgment of the state of the equipment, so that the chances of equipment failure can be gradually reduced. In this paper from the architectural point of view, IoT contains four layers: perception layer, network layer, platform layer, and application layer. The perception layer mainly solves the problem of data collection, the network layer mainly solves the problem of data transmission, the platform layer mainly solves the problem of data management, and the application layer mainly solves the problem of data value creation. From the technical point of view, the university laboratories’ Internet of Things widely used big data, cloud computing, Internet of Things, artificial intelligence, blockchain, edge computing, and other types of information technology and intelligent technology. From the role, the university laboratories’ IoT is to provide sufficient and effective information and technical support for planning and construction, production and operation, operation and management, integrated services, new business, new model development, enterprise ecosystem construction, and other aspects by bringing together resources from all aspects. The whole university laboratory system sustainability monitoring equipment maintains the continuity of monitoring and can be the first time to staff feedback fault information, to achieve the human-machine dialogue function; staff in the control of equipment safety monitoring system just enter the relevant instructions to fully achieve the purpose of control; staff can also print a certain period of time fault-related information, which will be properly stored in a reasonable location.