Characteristics of anomalous precipitation events during the past five centuries in North China (NC) and the middle-lower Yangtze River Valley (MLYRV) were investigated using the data network of dryness/wetness index (DWI) over eastern China. The high occurrence frequency of anomalous precipitation events mainly occurred at periods of high solar forcing, active volcanic eruption, and large anthropogenic forcing (the twentieth century). Coherence and dipole were the two dominant modes in spatial patterns of anomalous precipitation events. Coherent floods dominated the eighteenth and nineteenth centuries, whereas coherent droughts occurred frequently in the seventeenth and twentieth centuries. The dipole patterns of anomalous precipitation events were the most frequent in the twentieth century. NC experienced more floods in the cold periods than warm periods. Both NC and the MLYRV experienced far fewer droughts and more floods in the warm eighteenth century when natural climate forcing dominated, and more droughts in the twentieth century when anthropogenic forcing dominated. Coherent drought was the only spatial pattern of precipitation significantly associated with explosive low-latitude volcanic eruptions. The increased coherent droughts and dipole patterns in the twentieth century support the findings of previous modeling studies that the tropospheric aerosols and human-induced land cover changes play important roles in the changes of summer rainfall over eastern China.