AimThis aim of this study was to describe how legal guardians assessed health‐related quality of life and HIV‐related stigma in children with the human immunodeficiency virus (HIV) compared to the children's own ratings.MethodsA cross‐sectional nationwide study was performed to compare how 37 children aged from eight to 16 years of age with perinatal HIV, and their legal guardians, assessed the children's health‐related quality of life and HIV‐related stigma. Data were collected using the 37‐item DISABKIDS Chronic Generic Module and a short eight‐item version of the HIV stigma scale.ResultsIntraclass correlations indicated concordance between the legal guardians' ratings and the children's own ratings of the child's health‐related quality of life and HIV‐related stigma. There were no statistically significant differences between the ratings of the two groups and gender did not have any impact on the results. Both groups indicated that the children had concerns about being open about their HIV status.ConclusionThe results of this study indicated that legal guardians understood how their children perceived their health‐related quality of life and HIV‐related stigma. The results also indicated the need for interventions to support both the children and legal guardians when it came to disclosing the child's HIV status.