We review the major stable carbon and nitrogen isotope studies conducted on human remains in the North American Arctic (NAA) and discuss the findings with respect to two major research themes: diachronic subsistence, and the development of food cultures across the NAA. The interpretation of stable isotope data from human bone collagen and hair keratin is complicated by issues of equifinality in addition to uncertainty arising from the high fat/high protein diets of Arctic hunter gatherers. We suggest future lines of inquiry which may help to alleviate some of these challenges. Our review of Arctic stable isotope studies shows the ongoing potential of stable isotope analysis of Arctic hunter-gatherers and faunal populations, but we include the caveat that regardless of how cutting-edge or refined the analytical method, future stable isotope studies must be contextualized with other lines of evidence from well-excavated sites, and would profoundly benefit from the incorporation of indigenous perspectives and research priorities.