Grassland areas occupy 60% of the Qinghai-Tibetan Plateau (QTP) and play a critical role in enhancing the ecological barrier functions of the QTP. Grassland ecosystems, and net primary productivity (NPP) in general, have dramatically changed in time and space since the 1980s, with climate warming and the intensification of human activities. Current research widely believes that climate and human activities are the common driving factors of grassland ecosystem changes on the QTP. However, there is still controversy over their dominant driving factors and their contribution rates, especially during different research periods. Therefore, this study calculated the relative contributions of climate change, human activities (except LUCC) and LUCC to actual NPP (aNPP) changes during the two periods from 1982 to 2000 to 2001–2020. This study simulated three kinds of NPPs, that is, actual NPP, potential NPP, and human-appropriated NPP, using climate productivity, the light use efficiency model, and the residual method, respectively. Moreover, the study area was divided into two parts, and then the contributions of the three factors were calculated objectively. The results showed that (1) the actual NPP (aNPP) of the QTP increased dramatically from 1982 to 2000 but did not change obviously from 2001 to 2020. (2) Comprehensive evaluation showed that climate was the dominant factor for the aNPP net increase, and its contribution rate dramatically increased from 36.3% during 1982–2000 to 224.2% during 2001–2020. Human activities changed from a positive contribution (53.3%) to a negative contribution (−124.8%) to the aNPP net increase. The contribution rate of LUCC to the aNPP increase significantly decreased from 10.4% to 0.6%. Therefore, finer grassland restoration measures and government policies must be implemented to increase NPP against the background of favorable warm-wet climate conditions for increasing grassland NPP in the QTP. These results benefit the scientific management of grassland resources and ecological barrier building on the QTP.
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