Hue Test Research Articles

The impact of age-related cataracts on colour perception, postoperative recovery and related spectra derived from test of hue perception

BackgroundCataract patients were always excluded from studies on ageing of colour vision; thus, effect of age-related cataracts on deterioration of colour perception has not been analysed. In present study, impacts of age-related cataracts on colour discrimination, postoperative recovery and related spectra were investigated.MethodsIn this cohort study, thirty age-related cataract patients scheduled for binocular surgery and 30 elderly volunteers were enrolled. Colour discrimination under photopic (1000 lx) and mesopic (40 lx) conditions was evaluated with Farnsworth-Munsell 100-hue test. The total error score (TES) and partial error score (PES) were calculated.ResultsPreoperatively, the TES in the patient group was 129.7 ± 59.5 at 1000 lx and 194.6 ± 74.5 at 40 lx, exhibiting worse discrimination than the volunteer group (TES1000lux = 71.5 ± 37.5 and TES40lux = 113.1 ± 38.8, p ≤ 0.001). Inferior perception were detected in the yellow to green-yellow (Y-GY), green-yellow to green (GY-G), green to blue-green (G-BG) and blue-green to blue (BG-B) colour bands (p ≤ 0.003), corresponding to the 470 nm–580 nm range of the visible light spectrum. Under mesopic conditions, the impact expanded to all colour bands except for yellow-red to yellow (YR-Y). Postoperatively, the TES in the patient group were 80.4 ± 62.4 at 1000 lx and 112.0 ± 85.2 at 40 lx, which were lower than those of the preoperative phase (p ≤ 0.001) but similar to those of the volunteer group (p ≥ 0.505). Postoperative improvement occurred in the Y-GY, GY-G and G-BG colour bands (490 nm to 580 nm) at 1000 lx (p ≤ 0.001) and shifted to the Y-GY, GY-G, G-BG and BG-B colour bands (470 nm to 580 nm) at 40 lx (p ≤ 0.001). Deterioration of hue perception for decrement of illumination was detected in the red to yellow-red (R-YR), Y-GY, G-BG, BG-B, blue to purple-blue (B-PB) and red-purple to red (RP-R) colour bands (450 nm to 500 nm) in the volunteer group (p ≤ 0.002) and the R-YR, G-BG, BG-B, B-PB, PB-P and red-purple to red (RP-R) colour bands (from the short-wavelength end to 500 nm) in the patient group preoperatively (p ≤ 0.001).ConclusionsPhacoemulsification could effectively rebuild colour perception in patients with age-related cataract. The postoperative benefits were most significant in colour bands corresponding with spectrum from 470 nm to 580 nm.

Avaliação do padrão de acuidade visual para cores de acadêmicos da área de saúde em Universidade brasileira

ABSTRACT Objective: The goal of the study is to analyze the color vision acuity pattern in undergraduates of health courses and to discuss the impact of these diseases in this population. Color deficiencies interfere significantly in the daily routine of professionals in the health area who need to discern different color hues in several situations of their everyday practice. Methods: Sixty-four volunteers, undergraduates of health courses of the Federal University of Alfenas (UNIFAL-MG), participated in the study. One man was excluded because he did not fit the inclusion criteria. Two groups were analyzed according to sex with the Farnsworth Munsell 100-Hue test. Results: There were no significant differences between the eyes and between the groups analyzed. The color vision acuity pattern is between 35 and 40, according to the Total Error Score. The gender issue does not influence the general pattern of the color vision acuity of the health courses undergraduates when those with color vision disorders are removed. Conclusion: Screenings and guidance should be given to undergraduates of health courses so that, aware of their condition of presenting some type of color disorder, they shall make the appropriate decision on which career to follow so that such limitation does not interfere with the quality of their daily life.

Best lighting for jeans, part 1: Optimising colour preference and colour discrimination with multiple correlated colour temperatures

In this study, two psychophysical experiments, one on colour preference and the other on colour discrimination, were conducted. To investigate the colour preference for blue jeans, 27 subjects with normal colour vision were asked to rate their visual appreciation of seven pairs of jeans with a colour gradient pattern. Nine LEDs, with uniformly sampled correlated colour temperature (CCT) values ranging from 2500 K to 6500 K, were used to illuminate the jeans. These lights produced a constant illuminance of approximately 200 lux, and their colour rendering indexes were between 79 and 91. In addition, using a Farnsworth-Munsell (FM)-100 Hue Test, the blue-region colour discrimination of 42 observers was assessed for five LEDs of the same type but with different CCTs (2500 K–6500 K, 1000 K interval). The results indicate that there is an optimum CCT of 5500 K for jeans, at which observers were found to exhibit the greatest capability for colour discrimination and the highest rating for colour preference. Interestingly, a significant gender difference was found in this study, which had not been observed in our previous work with quite similar experimental settings but different experimental objects. The findings of this study should provide a deeper understanding for the lighting design of shopping malls for jeans.

Color vision testing versus pattern visual evoked potentials and optical coherence tomography parameters in subclinical optic nerve involvement in multiple sclerosis

Acute idiopathic demyelinating optic neuritis is frequently the initial manifestation of multiple sclerosis (MS). We aimed to discuss the value of color vision testing to detect possible optic nerve involvement in patients with MS who had no history of optic neuritis. We evaluated color vision with Farnsworth-Munsell 100 (FM-100) hue test. Total error scores (TES), partial error scores for the red-green axis (RGS) and blue-yellow axis (BYS) were calculated. Topographic optic disc parameters (RNFL, RA, DA, CV, RV, and vertical C/D ratio), total macular volume (TMV), central macular thickness (CMT), and retinal ganglion cell layer (RGCL) were determined using spectral domain optical coherence tomography (SD-OCT). Choroidal thickness (CT) was measured using enhanced depth imaging optical coherence tomography (EDI-OCT). Pattern visual evoked potentials (PVEP) were also performed. Twenty-eight patients with RRMS (56 eyes) and 25 healthy controls (50 eyes) were included. P100 latencies were significantly delayed and P100 amplitudes were significantly reduced in the patient group compared with the controls (p ≤ 0.05). Statistically significant thinning was found in temporal quadrant in the patient group compared with the controls (p = 0.002). TES RGS, and BYS were all increased in the patient group but this was not statistically significant. We found no correlation between TES, RGS, BYS, and P100 latencies or OCT parameters. In our investigation as to whether color vision testing could be a simple biomarker for showing neurodegeneration of the anterior visual pathway regardless of optic neuritis, PVEP and OCT-assessed RNFL thickness seemed to be a more valuable biomarker than color vision testing.

Color Vision Tests in Pilots' Medical Assessments.

The aim of this study was to evaluate the ability of eight color vision tests to screen for and accurately measure hereditary color-deficiency in order to improve color vision assessment methods for aircraft pilots. This prospective study included 29 color-deficient subjects and 23 healthy subjects. All performed the following tests: Ishihara plates, Farnsworth D15, Lanthony desaturated 15 Hue, Munsell 100 Hue, Beyne and Fletcher-Evans CAM lanterns, Nagel anomaloscope, and the Color Assessment and Diagnosis (CAD) test. The sensitivity and specificity of color-deficiency diagnosis were evaluated for each test, as well as the test's relevance for assessing aircraft pilots. The Ishihara plate test demonstrated a sensitivity of 0.97 and a specificity of 1.00 for color-deficiency screening. The CAD test and anomaloscope showed both a sensitivity and specificity of 1.00. The Beyne lantern, Fletcher lantern, Farnsworth D15, and the Lanthony 15 Hue tests all showed a specificity of 1.00 and sensitivities of, respectively, 0.69, 0.97, 0.58, and 0.79. During aircraft pilot selection tests, the CAD test classified 10% of color-deficient subjects as safe to fly, the anomaloscope 17%, and the Beyne and Fletcher lantern tests, respectively, 31% and 3%. The discrepancy in results confirms that current color vision test protocols need to be reassessed. The CAD test could be an interesting alternative to the series of tests used to assess flight crew, but it seems more selective than current tests.Marechal M, Delbarre M, Tesson J, Lacambre C, Lefebvre H, Froussart-Maille F. Color vision tests in pilots' medical assessments. Aerosp Med Hum Perform. 2018; 89(8):737-743.

Usher Syndrome and Color Vision

ABSTRACTPurpose: The aim of this study is to report on the results of color vision testing in a European cohort of patients with Usher syndrome (USH). We describe the results in relation to Usher type (USH1 and USH2), age and visual acuity.Methods and methods: The color vision of 220 genetically confirmed adult USH patients, aged 18–70 years, was analyzed with one of three methods: the Farnsworth D-15 Dichotomous test (D-15) along with the Lanthony desaturated 15 Hue tests (D-15d), the Roth 28-Hue test, or the Ishihara 14-plate test. Visual acuity was measured with either the ETDRS or the SNELLEN charts. The Confusion index, the Selectivity index and the Confusion angle were calculated for the panel tests and used for analysis. The numbers of plates that could not be read were analyzed for the Ishihara test.Results: For the panel tests, the degree of color loss (Confusion index) is similar in both subtypes of USH, but the polarization of error scores (Selectivity index) is significantly lower in USH1 than USH2, showing more diffuse errors than those found in USH2. There is no significant correlation between logMAR visual acuity and the Confusion or the Selectivity indices. Additionally, we find a significant correlation between patient age and the degree and the polarity of the loss only in USH2. There was no difference between USH1 and USH2 in the results of the Ishihara test.Conclusions: The examination of color vision in patients with USH shows a significant difference in the pattern of color vision loss in USH1 and USH2 patients, but not in the severity of the loss. In USH2, we find a correlation between patient age and the degree and the polarity of the loss. These results may be due to differences in the pathogenesis of retinal dystrophy in USH1 and USH2.

Color vision deficiency among biomedical students: a cross-sectional study.

PurposeTo determine the prevalence of color vision deficiency (CVD) among first-cycle students of the Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I.Patients and methodsA cross-sectional descriptive study was carried out between October 1, 2015 and May 31, 2016. Distant visual acuity was measured and color vision test done for all consenting students. Ishihara’s plates were used to test all the participants. Those who failed the test were tested with the Roth’s 28 Hue test for confirmation of CVD and classification.ResultsA total of 303 students were included, among whom 155 were males (50.8%) and 148 were females (49.2%). The mean age was 20.2±2 years. Five students (1.6%) failed the Ishihara’s plate testing. Roth’s 28 Hue test confirmed CVD in 4 of those cases, giving a prevalence of 1.3%. There were equal numbers of protan and deutan CVD.ConclusionDespite its low prevalence among first-cycle students of the Faculty of Medicine and Biomedical Sciences, CVD screening should be performed in order to raise awareness, which will go a long way to help orientate the choice of future specialty.

Do Type 1 Diabetes Mellitus and Color-Vision Deficiencies Influence Shade-Matching Ability?

To evaluate the effect of color-vision deficiencies and type 1 diabetes mellitus (DM) on visual shade-matching ability. Four groups of participants were investigated: a control group (n = 68); a group with protanomalia (n = 10); a group with deuteranomalia (n = 19); and a group with type 1 DM (n = 13). Color vision was evaluated monocularly using the Ishihara test, Farnsworth-Munsell 100 hue (FM100H) test, Hardy Rand Rittler (HRR) test, and with an HMC Anomaloskop MR (Rayleigh and Moreland tests). The final exam was on a Toothguide Training Box (TTB) and consisted of 15 lightness-chroma-hue tasks. The color difference (ΔE*ab) and the shade-matching score (ΣΔE*ab) were computed, and the correct lightness (L*), chroma (C*), and hue (h*) selections were counted. The means and standard deviations for the ΣΔE*ab, ΔE*ab, L*, C*, h*, Ishihara, HRR, FM100H, and Rayleigh and Moreland tests were calculated. One-way analysis of variance (ANOVA) and post hoc Bonferroni test were used for statistical analyses and a comparison of means (α = .05). The data analyses were performed using SPSS 22.0 for Windows (IBM). The control group selected the shade tab on the TTB significantly better (ΣΔE*ab = 31.57 ± 13.50) than the group with protanomalia (ΣΔE*ab = 55.50 ± 12.36; P < .0001) and the group with deuteranomalia (ΣΔE*ab = 59.18 ± 16.35; P < .0001), but not significantly better than the group with type 1 DM (ΣΔE*ab = 39.43 ± 11.46; P = .368). The group with type 1 DM selected the shade tab on the TTB significantly better than the group with protanomalia (P = .038) and the group with deuteranomalia (P < .0001). Participants with color-vision deficiencies are less accurate at shade matching than the control group and the group with type 1 DM.

Links between global and local shape perception, coloured backgrounds, colour discrimination, and non-verbal IQ

This study explored associations between local and global shape perception on coloured backgrounds, colour discrimination, and non-verbal IQ (NVIQ). Five background colours were chosen for the local and global shape tasks that were tailored for the cone-opponent pathways early in the visual system (cardinal colour directions: L-M, loosely, reddish-greenish; and S-(L + M), or tritan colours, loosely, blueish-yellowish; where L, M and S refer to the long, middle and short wavelength sensitive cones). Participants also completed the Farnsworth-Munsell 100-hue test (FM100) to determine whether performance on the local and global shape tasks correlated with colour discrimination overall, or with performance on the L-M and tritan subsets of the FM100 test. Overall performance on the local and global shape tasks did correlate with scores on the FM100 tests, despite the colour of the background being irrelevant to the shape tasks. There were also significantly larger associations between scores for the L-M subset of the FM100 test, compared to the tritan subset, and accuracy on some of the shape tasks on the reddish, greenish and neutral backgrounds. Participants also completed the non-verbal components of the WAIS and the SPM+ version of Raven’s progressive matrices, to determine whether performance on the FM100 test, and on the local and global shape tasks, correlated with NVIQ. FM100 scores correlated significantly with both WAIS and SPM+ scores. These results extend previous work that has indicated FM100 performance is not purely a measure of colour discrimination, but also involves aspects of each participant’s NVIQ, such as the ability to attend to local and global aspects of the test, part-whole relationships, perceptual organisation and good visuomotor skills. Overall performance on the local and global shape tasks correlated only with the WAIS scores, not the SPM+. These results indicate that those aspects of NVIQ that engage spatial comprehension of local-global relationships and manual manipulation (WAIS), rather than more abstract reasoning (SPM+), are related to performance on the local and global shape tasks. Links are presented between various measures of NVIQ and performance on visual tasks, but they are currently seldom addressed in studies of either shape or colour perception. Further studies to explore these issues are recommended.

Dental Shade Matching and Value Discernment Abilities of First-Year Dental Students.

To determine if Farnsworth-Munsell 100 Hue Test, Perceptual Ability Test, gender, age, ethnicity, and time predict dental shade matching and value discernment in first-year dental students. Farnsworth-Munsell 100 Hue Test was administered to 95 first-year-dental students beneath a Judge II booth (color temperature of 6500°K, and color rendering index of 90). Students also arranged 16 masked shade tabs from a Vita Classic shade guide by value (lightest to darkest) and matched together 16 pairs of masked shade tabs from two Vita Classic shade guides. Ethnicity, age, Perceptual Ability Test scores, gender, and time to complete the tests were recorded. Associations and correlations were investigated using chi-square, Tukey-Kramer HSD, standard least square, and multilinear regression (p < 0.05). Total error scores on the Farnsworth-Munsell 100 Hue Test ranged from 0 to 144. Forty-eight students exhibited superior color acuity, 45 average, and two poor. The mean number of correct answers for matching shade tabs together was 11.6, and 6.1 for arranging the shade tabs by value. Females performed statistically better than males on the Farnsworth-Munsell 100 Hue Test and shade tab matching. Better color discrimination identified by lower total error scores on the Farnsworth-Munsell 100 Hue Test was directly correlated to greater ability to match shade tabs together. Perceptual Ability Test scores had slight significance. As the scores increased there was slightly better performance on the Farnsworth-Munsell 100 Hue Test. Older participants performed better than younger subjects on the value test. No other correlations were significant for any of the tests. Females and individuals who performed better on the Farnsworth-Munsell 100 Hue Test have improved dental shade-matching ability.

Depressive Symptoms Are Associated With Color Vision but not Olfactory Function in Patients With Parkinson's Disease.

Depressive symptoms and sensory dysfunction, such as reduction in visual and olfactory function, are common in Parkinson's disease (PD). Previous studies have suggested that depressive symptoms are associated with visual impairments and potentially with hyposmia in several types of mood disorders. However, the relationship between depressive symptoms and sensory dysfunction remains unclear in PD. To examine the association of depressive symptoms with color vision and olfactory function in PD, the authors conducted a cross-sectional study in 159 patients with PD. Depressive symptoms were measured with the Beck Depression Inventory-II (BDI-II) and the 30-item Geriatric Depression Scale (GDS-30); color vision was tested with the Farnsworth-Munsell 100 Hue Test (FMT); and olfactory function was tested with the Sniffin' Sticks Screening 12 Test. Results showed that the total error score (TES) for the FMT was significantly and independently correlated with scores on both the BDI-II and GDS-30 in a positive manner, suggesting that more severe depressive symptoms are associated with poorer color vision in PD. In addition, both somatic and effective subscores for the BDI-II were correlated with the TES on the FMT, while no significant correlation was observed between total scores on the Sniffin' Sticks Screening 12 Test and BDI-II or GDS-30. The decrease in color vision but not olfactory function was found to be associated with the severity of depressive symptoms in PD patients, supporting the idea that the occurrence of depressive symptoms in PD is linked with disruption of the visual system.

Automated Diagnostic Method of Color Vision Disorders Integrated with a Hospital Information System

Visual perception disorders diagnostics is a set of complex medical procedures. Those designated to diagnose color vision, particularly Farnsworth-Munsell 100 Hue Test, are in most cases performed manually, thus not only being time-consuming but also prone to errors and inaccuracy. Therefore, such manual methods are not used as often, even though they are powerful in nature.This paper proposes a software-based approach to color vision disorders diagnostics which automates and simplifies the medical examination procedure, and allows for almost immediate results analysis. Its utilization is not only limited to hospital environment as the software application can also be deployed on mobile devices. Results of statistical analysis show that use of the designed software for color vision disorders diagnosis provides significantly better results in terms of accuracy and speed. With an user-friendly interface, the application could become a tool which would enable patients to be examined on more frequent basis so as to see trends of disorder progression, and thus being more responsive in tailoring the medical treatment.

Translucence perception is not dependent on cortical areas critical for processing colour or texture

Translucence is an important property of natural materials, and human observers are adept at perceiving changes in translucence. Perceptions of different material properties appear to arise from different cortical regions, and it is therefore plausible that the perception of translucence is dependent on specialised regions, separate from those important for colour and texture processing. To test for anatomical independence between areas necessary for colour, texture and translucence perception we assessed translucency perception in a cortically colour blind observer, who performs at chance on tasks of colour and texture discrimination. Firstly, in order to establish that MS has shown no significant recovery, we assessed his colour perception performance on the Farnsworth-Munsell 100 Hue Test. Secondly, we tested him with two translucence ranking tasks. In one task, stimuli were images of glasses of tea varying in tea strength. In the other, stimuli were glasses of tea varying only in milkiness. MS was able to systematically rank both strength and milkiness, although less consistently than controls, and for tea strength his rankings were in the opposite order. An additional group of controls tested with greyscale versions of the images succeeded at the tasks, albeit slightly less consistently on the milkiness task, showing that the performance of normal observers cannot be transformed into the performance of MS simply by removing colour information from the stimuli. The systematic performance of MS suggests that some aspects of translucence perception do not depend on regions critical for colour and texture processing.

A new measure of colour discrimination for LEDs and other light sources

We show conclusively that, contrary to common belief, larger gamut area is not associated with better colour discrimination. We propose a new measure of colour discrimination, Rd, which quantifies the number of cap transpositions in the Farnsworth-Munsell 100 Hue Test (FM-100) that are introduced by a source spectrum. Rd was developed from 480 FM-100 tests (24 light sources × 20 participants per source), where the light source spectra systematically varied in IES Rf (from 65 to 95), Rg (from 80 to 120), and gamut shape. Rd was back tested on more than 200 common light sources to verify accordance with experience and anecdote and is a strong predictor of colour discrimination. We offer a direct way to interpret the Rd score. Light sources with superior colour discrimination have an Rd score of zero, meaning they introduce no transpositions, thus preserving FM-100 cap order. Light sources with average colour discrimination have an Rd score between 4 and 12; sources with poor colour discrimination have an Rd score of 16 or greater.

Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control.

ObjectiveAttention Deficit / Hyperactivity Disorder (ADHD) and Chronic Tic Disorder (CTD) are two common and frequently co-existing disorders, probably following an additive model. But this is not yet clear for the basic sensory function of colour processing sensitive to dopaminergic functioning in the retina and higher cognitive functions like attention and interference control. The latter two reflect important aspects for psychoeducation and behavioural treatment approaches.MethodsColour discrimination using the Farnsworth-Munsell 100-hue Test, sustained attention during the Frankfurt Attention Inventory (FAIR), and interference liability during Colour- and Counting-Stroop-Tests were assessed to further clarify the cognitive profile of the co-existence of ADHD and CTD. Altogether 69 children were classified into four groups: ADHD (N = 14), CTD (N = 20), ADHD+CTD (N = 20) and healthy Controls (N = 15) and compared in cognitive functioning in a 2×2-factorial statistical model.ResultsDifficulties with colour discrimination were associated with both ADHD and CTD factors following an additive model, but in ADHD these difficulties tended to be more pronounced on the blue-yellow axis. Attention problems were characteristic for ADHD but not CTD. Interference load was significant in both Colour- and Counting-Stroop-Tests and unrelated to colour discrimination. Compared to Controls, interference load in the Colour-Stroop was higher in pure ADHD and in pure CTD, but not in ADHD+CTD, following a sub-additive model. In contrast, interference load in the Counting-Stroop did not reveal ADHD or CTD effects.ConclusionThe co-existence of ADHD and CTD is characterized by additive as well as sub-additive performance impairments, suggesting that their co-existence may show simple additive characteristics of both disorders or a more complex interaction, depending on demand. The equivocal findings on interference control may indicate limited validity of the Stroop-Paradigm for clinical assessments.

Validity of the Worth 4 Dot Test in Patients with Red-Green Color Vision Defect.

The Worth four dot test uses red and green glasses for binocular dissociation, and although it has been believed that patients with red-green color vision defects cannot accurately perform the Worth four dot test, this has not been validated. Therefore, the purpose of this study was to demonstrate the validity of the Worth four dot test in patients with congenital red-green color vision defects who have normal or abnormal binocular vision. A retrospective review of medical records was performed on 30 consecutive congenital red-green color vision defect patients who underwent the Worth four dot test. The type of color vision anomaly was determined by the Hardy Rand and Rittler (HRR) pseudoisochromatic plate test, Ishihara color test, anomaloscope, and/or the 100 hue test. All patients underwent a complete ophthalmologic examination. Binocular sensory status was evaluated with the Worth four dot test and Randot stereotest. The results were interpreted according to the presence of strabismus or amblyopia. Among the 30 patients, 24 had normal visual acuity without strabismus nor amblyopia and 6 patients had strabismus and/or amblyopia. The 24 patients without strabismus nor amblyopia all showed binocular fusional responses by seeing four dots of the Worth four dot test. Meanwhile, the six patients with strabismus or amblyopia showed various results of fusion, suppression, and diplopia. Congenital red-green color vision defect patients of different types and variable degree of binocularity could successfully perform the Worth four dot test. They showed reliable results that were in accordance with their estimated binocular sensory status.

FM 100 색상검사를 이용한 표준광원 D65, TL84, A에서의 색채지각

FM 100 색상검사를 이용한 표준광원 D65, TL84, A에서의 색채지각

Structural and Functional Recovery Following Limited Iatrogenic Macular Detachment for Retinal Gene Therapy

The early decline and recovery of retinal structure and function following iatrogenic macular detachment for retinal gene therapy is not well characterized in those with relatively preserved central visual function. Here, the recovery of retinal structure and function over the first month following iatrogenic retinal detachment for the delivery of adeno-associated viral vector encoding Rab Escort Protein 1 is described as a part of gene therapy for choroideremia. To study changes in both retinal structure and function during the first month following iatrogenic macular detachment surgery. This prospective interocularly controlled study was conducted between February 1 and December 31, 2015. Treatment consisted of a subretinal injection of 0.1 mL of a gene therapy solution containing 1 × 1011 viral particles performed unilaterally. The participants were 5 males, aged 23 to 71 years, with a clinical and genetic diagnosis of choroideremia. Retinal structure and function were assessed at baseline, 1 week, and 1 month using optical coherence tomography, logMAR visual acuity, microperimetry, the Farnsworth-Munsell (FM) 100-hue test, and the Rayleigh match. Five white male patients aged 23 to 71 years underwent unilateral subretinal gene therapy for genetically confirmed choroidermeia. Optical coherence tomographic images demonstrated a complete resolution of the resulting iatrogenic retinal detachment by 1 week in all 5 patients. At 1 month, the mean (SE) change in central foveal thickness was +9.6 (7.2) μm in treated eyes and +8.8 (12.6) μm in control eyes. The mean (SE) change in visual acuity was +5.4 (3.3) letters in treated eyes and +0.8 (3.1) letters in control eyes. At 1 month, the mean (SE) threshold sensitivity changes were -1.2 (2.1) dB in treated eyes and -1.0 (1.2) dB in control eyes. Color discrimination at the FM 100-hue changed little at 1 month (mean [SE] change in C-index, -0.2 [0.4] in treated eyes and 0.1 [0.2] in control eyes). Rayleigh matches in 1 patient were consistent with a diagnosis of pseudoprotanomaly, suggesting decreased effective optical density of the cone photopigments. Retinal structural recovery-as assessed by optical coherence tomography-occurs soon after iatrogenic detachment. Similarly, visual acuity recovers or improves within 1 month of the procedure and may not be accompanied by improvements in threshold sensitivity or color discrimination. Changes in color matching in 1 patient suggest decreased optical density of the cone photopigments in the early postoperative period.

STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF BENIGN FLECK RETINA USING MULTIMODAL IMAGING

To report structural and functional features in a case series of benign fleck retina using multimodal imaging. Four cases with benign fleck retina underwent complete ophthalmic examination that included detailed history, visual acuity, and refractive error testing, FM-100 hue test, dilated fundus evaluation, full field electroretinogram, fundus photography with autofluorescence, fundus fluorescein angiography, and swept-source optical coherence tomography. Age group of the cases ranged from 19 years to 35 years (3 males and 1 female). Parental consanguinity was reported in two cases. All of them were visually asymptomatic with best-corrected visual acuity of 20/20 (moderate astigmatism) in both the eyes. Low color discrimination was seen in two cases. Fundus photography showed pisciform flecks which were compactly placed on posterior pole and were discrete, diverging towards periphery. Lesions were seen as smaller dots within 1500 microns from fovea and were hyperfluorescent on autofluorescence. Palisading retinal pigment epithelium defects were seen in posterior pole on fundus fluorescein angiography imaging; irregular hyper fluorescence was also noted. One case had reduced cone responses on full field electroretinogram; the other three cases had normal electroretinogram. On optical coherence tomography, level of lesions varied from retinal pigment epithelium, inner segment to outer segment extending till external limiting membrane. Functional and structural deficits in benign fleck retina were picked up using multimodal imaging.

Contrast sensitivity and its determinants in people with diabetes: SN-DREAMS-II, Report No 6.

PurposeTo assess contrast sensitivity (CS) and to elucidate the factors associated with CS among subjects with type 2 diabetes in a cross-sectional population-based study.Patients and methodsSubjects were recruited from a follow-up cohort, Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular genetics Study (SN-DREAMS II). Of 958 subjects who were followed up in SN-DREAMS II, a subset of 653 subjects was included in the analysis. All subjects underwent a comprehensive eye examination, which included CS assessment using the Pelli-Robson chart. The cross-sectional association between CS and independent variables was assessed using stepwise linear regression analysis. A P-value of <0.05 was considered statistically significant.ResultsThe mean age of the study sample was 58.7±9.41 (44-87) years. Mean CS of the study sample was 1.32±0.20 (range: 0-1.65) log units. CS was negatively and significantly correlated with age, duration of diabetes, hemoglobin level, vibration perception threshold (VPT) value, albuminuria, best corrected visual acuity (BCVA), refractive error, total error score (TEM) of FM 100 hue test, and mean retinal sensitivity. In multiple regression analysis, after adjusting for all the related factors, CS was significantly associated with BCVA (β=-0.575; P<0.001), VPT (β=-0.003; P=0.010), severity of cataract (β=-0.018; P=0.032), diabetic retinopathy (β=-0.016; P=0.019), and age (β=-0.002; P=0.029). These factors explained about 29.3% of the variation in CS.ConclusionAmong the factors evaluated, differences in BCVA were associated with the largest predicted differences in CS. This association of CS with visual acuity highlights the important role of visual assessment in type 2 diabetes.