Communication Hub Research Articles

New horizons of science popularization in libraries

In the recent decade, the interest in popular science seminars, lectures and master classes has been growing, which is evidenced by the specialists of libraries, museums and educational organizations. The authors argue that the dialogue between science and society should be enhanced, and it is important to attract public attention to the achievements in science and technology and to cultivate learning interest. The authors review the process of science popularization in Russia and the world, as science popularization is seen as the essential part of educating information literacy and engaging wider community in the world of scientific knowledge. The authors discuss various methods and instruments of science and technology popularization. The focus is made on the role of specialized and academic libraries being the hubs of knowledge dissemination and scientific communication, and supporting different user groups. The authors provide several recommendations for the libraries, in particular, on how to organize popular science events and to develop specialized programs for different age user groups. New options for preserving scientific knowledge digital collections, their processing and further utilization, are also proposed.

Online Integrated Platform for Project Management

The Integrated Platform for University Projects (IPUP) aims to streamline student project management across academic disciplines. Utilizing web technologies and project management principles, IPUP provides a centralized hub for collaboration, communication, and progress tracking. Additionally, IPUP utilizes a plagiarism checking API as a method to ensure academic integrity. Project documentation submitted on the platform is analysed using the SmallSEO Tools Plagiarism checking API. This API employs algorithms defined by SmallSEO Tools to detect any plagiarized content within the documentation. The API returns a response indicating the percentage of content identified as copied. A predetermined threshold is set for this percentage; if the value exceeds this threshold, the submission is rejected by the website. IPUP serves as a driving force for academic innovation, enabling cross-disciplinary learning and excellence in project-based education, while also integrating communication tools and prioritizing data security.

Tracing Trajectories: Qualitative Visualizations of Migrant Death in South Texas, 1993–2020

Executive Summary This paper explores how qualitative information may be used to enhance understanding and inform recommendations for improved accounting of migrant deaths along the Texas-Mexico border. While border crossing related deaths affect jurisdictions throughout the US’s Southwestern border states and Northern Mexican states, Texas has unique challenges that merit specific examination. In short, the management and investigation of unidentified migrant decedents in Texas is severely fragmented and often noncompliant with Texas Criminal Code Procedure. I explore a way to improve accounting of migrant deaths leveraging qualitative information, local newspaper articles from South Texas and Northern Mexico, by using descriptive summaries coupled with Sankey Diagrams and a programmatic technique, qualitative spatial representation (QSR). QSR enabled me to identify under-recognized stakeholders (South Texas locals, Mexican consulates) and under-supported counties (i.e., those with migrant deaths that do not share a border directly with Mexico). I found that local English-language newspapers obscured the prevalence of migrant deaths and that their narrative tone of “business as usual” normalized the occurrence of such deaths. The Spanish-language articles better represented the diversity of agencies and individuals that were involved in the various aspects of migrant remains management and forensic investigation, most notably residents of South Texas themselves (or situational participants who first found the remains) and Mexican consulates. Finally, I noted that the collaborations among Texas counties and between Texan and Mexican jurisdictions, when they were described in the newspapers, highlighted that the phenomenon of migrant deaths penetrates beyond the dividing line of the Rio Grande/Río Bravo River. Migrant deaths must be accounted for in a way that reflects a regional experience in which people may perish as far as ~100 miles into Texas’ interior. Considering these observations, I have two policy recommendations. First, the Office of the Texas Governor should establish funds distinct from the Operation Lone Star program for the management of unidentified human remains. Currently, grants through the Operation Lone Star Program are the only funds available in Texas to support identification of migrant decedents. However, this program is explicitly designed to further border security operations in the state of Texas, which can contradict efforts around recovery and identification. The documentation and forensic investigation of the unidentified deceased can be eclipsed or neglected under the larger deterrence aims of Operation Lone Star. Second, to improve accounting and increase documentation of migrant deaths, a Regional Identification Center should be established in South Texas. Not every county in Texas has or has access to a Medical Examiner’s office, including the means to transport and pay for autopsy or other forensic services. The Center would provide training, store extra equipment such as mobile refrigerated morgues, and hire personnel to inventory cases, and report information to the state (e.g., vital statistics) and to foreign consulates. A Regional Identification Center would counteract the challenges highlighted in the local newspaper summaries and QSR by decreasing the isolation of counties experiencing migrant deaths and serve as a documentary and communication hub for stakeholders in Texas and Mexico.

Female pumas exhibit behavioral plasticity through partitioning temporal activity at communication hubs based on life stage

AbstractIntraspecific communication among carnivores can be complex and risky, and many solitary carnivores (including pumas; Puma concolor) primarily communicate with potential mates and competitors indirectly via scent marking at communication hubs. We used multiple temporal analyses to understand if pumas of three classes (males, solo females, and females traveling with dependent kittens) varied in their temporal use of communication hubs to reduce risk while gathering information. We hypothesized that males would visit scrapes at typical times (nighttime), but that female behavioral strategies might vary based on whether they had dependent kittens or not. We found that pumas of different classes varied in their temporal patterns: male pumas concentrated their temporal activity at night (which is typical for pumas), solo females also tended to visit during the nighttime (although slightly earlier on average than males), while females with kittens were more active in the daytime. Our findings highlight the importance of communication hubs for intersexual communication in pumas and the flexibility that is inherent in puma behavioral ecology. Females adjusted their temporal behavior and visitation based on their reproductive status and life history stage, likely to assess dominant territorial males while also limiting their risk. Our study provides a mechanistic view of how communication through scent marking allows both long‐term and spatially separated communication to occur and that may allow pumas at different life stages with different risk tolerances to communicate with each other.

Changes in Neuroimmunological Synapses During Cerebral Ischemia.

The direct interplay between the immune and nervous systems is now well established. Within the brain, these interactions take place between neurons and resident glial cells, i.e., microglia and astrocytes, or infiltrating immune cells, influenced by systemic factors. A special form of physical cell-cell interactions is the so-called "neuroimmunological (NI) synapse." There is compelling evidence that the same signaling pathways that regulate inflammatory responses to injury or ischemia also play potent roles in brain development, plasticity, and function. Proper synaptic wiring is as important during development as it is during disease states, as it is necessary for activity-dependent refinement of neuronal circuits. Since the process of forming synaptic connections in the brain is highly dynamic, with constant changes in strength and connectivity, the immune component is perfectly suited for the regulatory task as it is in constant turnover. Many cellular and molecular players in this interaction remain to be uncovered, especially in pathological states. In this review, we discuss and propose possible communication hubs between components of the adaptive and innate immune systems and the synaptic element in ischemic stroke pathology.

An Analysis of The Agribusiness Communication Structure of Dairy Cattle Farmers: The Case Study of The Tegal Mandiri Farmer Group

Problems in dairy cattle agribusiness require attention not only from the farmers themselves but also from farmer organizations. To understand the communication patterns among group members in the agribusiness sector, including the exchange of information related to cattle production, animal health, and wholesale prices, it is essential to analyze the communication network of the dairy cattle farmer group. This network is significant because it serves as the hub of organizational communication, both internally and externally. This research seeks to analyze the communication structure of the dairy cattle farmer group and investigate the relationship between the respondent characteristics and the communication networks within the Tegal Mandiri farmer group in Bogor Regency. The Social Network Analysis (SNA) method and a quantitative approach were used to conduct the research, with the Tegal Mandiri farmer group members in Bogor Regency as the unit of analysis. The group communication structure was analyzed using degree and closeness centrality, and the relationship between respondent characteristics and the communication network was analyzed using Spearman rank correlation. IBM SPSS Statistics 26 and UCINET 6 were the tools used for analysis. The study revealed that 1) the average degree centrality of the group was between 1.00 and 2.20, and the average closeness centrality was between 400.00 and 558.10. 2) The respondents' characteristics of farmers were significantly related to the communication networks within the group. The study found that the communication structure of the Tegal Mandiri farmer group exhibited low connectivity and an ineffective coordination forum

3D Imaging of Lipid Droplet-Nuclear Membrane Contact Sites and Cirrhotic Lipid Droplet Overexpression.

To coordinate cellular physiology, cells rely on the rapid exchange of molecules at specialized organelle-organelle contact sites. Lipid droplets (LDs) and nuclear membrane (NM) contact sites are particularly vital communication hubs, playing key roles in the exchange of signaling molecules, lipids, and metabolites. However, there is still a lack of understanding of the specific morphology of the contact sites. Here, we combine advanced three-dimensional (3D) imaging with a high-brightness fluorescent probe specifically targeting LDs to map the structural landscape of LD-NM contact sites. The probe exhibits exceptional photophysical properties, making it highly suitable for visualizing the changes occurring in LDs during the apoptosis process. In addition, we utilize the advantages of the probe to accurately monitor the overexpression of abnormal LDs in cirrhosis by 3D imaging for the first time. The outcomes of this investigation highlight that the probe has potential as a robust imaging tool to investigate intricate biological functions of LDs and their implications in related diseases.

Identification of Hypoxia-ALCAMhigh Macrophage- Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance.

Although hypoxia is known to be associated with immune resistance, the adaptability to hypoxia by different cell populations in the tumor microenvironment and the underlying mechanisms remain elusive. This knowledge gap has hindered the development of therapeutic strategies to overcome tumor immune resistance induced by hypoxia. Here, bulk, single-cell, and spatial transcriptomics are integrated to characterize hypoxia associated with immune escape during carcinogenesis and reveal a hypoxia-based intercellular communication hub consisting of malignant cells, ALCAMhigh macrophages, and exhausted CD8+ T cells around the tumor boundary. A hypoxic microenvironment promotes binding of HIF-1α complex is demonstrated to the ALCAM promoter therefore increasing its expression in macrophages, and the ALCAMhigh macrophages co-localize with exhausted CD8+ T cells in the tumor spatial microenvironment and promote T cell exhaustion. Preclinically, HIF-1ɑ inhibition reduces ALCAM expression in macrophages and exhausted CD8+ T cells and potentiates T cell antitumor function to enhance immunotherapy efficacy. This study reveals the systematic landscape of hypoxia at single-cell resolution and spatial architecture and highlights the effect of hypoxia on immunotherapy resistance through the ALCAMhigh macrophage-exhausted T cell axis, providing a novel immunotherapeutic strategy to overcome hypoxia-induced resistance in cancers.

Sync Alert Notice Board

The SyncAlert Notice Board project represents a significant advancement in communication technology, leveraging a sophisticated integration of hardware components to create a versatile communication hub. At its core, the project features a 45x6 LED matrix, enabling vivid and customizable display capabilities for messages and notifications. This matrix is complemented by an RTC (Real-Time Clock) module, ensuring accurate timekeeping and scheduling functionalities essential for managing events and deadlines effectively. In addition to visual communication, the project incorporates an MP3 module, adding an auditory dimension to message delivery and enhancing user engagement. The integration of a Bluetooth HC05 module further enhances the project's utility by enabling seamless wireless transmission of data, allowing users to update the notice board remotely and in real time. This combination of features transforms the SyncAlert Notice Board into a dynamic and interactive communication tool suitable for a wide range of environments, from educational institutions to corporate offices. By addressing the specific needs of users for efficient information dissemination and scheduling management, the SyncAlert Notice Board project offers a comprehensive solution that not only streamlines communication but also enhances organizational productivity and engagement. Its versatility, coupled with user-friendly functionality, makes it an invaluable asset for any setting where clear and timely communication is paramount

A conflict-free CAN-to-TSN scheduler for CAN-TSN gateway

The automotive Electrical/Electronic (E/E) architecture with Time-Sensitive Networking (TSN) as the backbone network and Controller Area Network (CAN) as the intra-domain network has attracted extensive research attention. In this architecture, the CAN-TSN gateway serves as a vital hub for communication between the CAN and TSN networks. However, with frequent information exchange between domains, multiple real-time applications inevitably compete for the same network resources. The limited availability of schedule table entries and bandwidth allocation pose challenges in scheduling design. To mitigate the transmission conflicts at the CAN-TSN gateway, this paper proposes a CAN-to-TSN scheduler consisting of two primary stages. The first stage introduces the Message Aggregation Optimization (MAO) algorithm to aggregate multiple CAN messages into a single TSN message, ultimately decreasing the communication overhead and the schedule table entries number. The second stage proposes the Exploratory Message Scheduling Optimization (EMSO) algorithm based on MAO. EMSO disaggregates and reassembles the CAN messages with small deadlines within the currently un-scheduled TSN message to improve the acceptance ratio of CAN messages. Experimental results demonstrate that EMSO achieves an average acceptance ratio of CAN messages 4.3% higher in preemptive mode and 8.2% higher in non-preemptive mode in TSN than state-of-the-art algorithms.

A communication hub for phosphoregulation of kinetochore-microtubule attachment

The Mps1 and Aurora B kinases regulate and monitor kinetochore attachment to spindle microtubules during cell division, ultimately ensuring accurate chromosome segregation. In yeast, the critical spindle attachment components are the Ndc80 and Dam1 complexes (Ndc80c and DASH/Dam1c, respectively). Ndc80c is a 600-Å-long heterotetramer that binds microtubules through a globular "head" at one end and centromere-proximal kinetochore components through a globular knob at the other end. Dam1c is a heterodecamer that forms a ring of 16-17 protomers around the shaft of the single kinetochore microtubule in point-centromere yeast. The ring coordinates the approximately eight Ndc80c rods per kinetochore. In published work, we showed that a site on the globular "head" of Ndc80c, including residues from both Ndc80 and Nuf2, binds a bipartite segment in the long C-terminal extension of Dam1. Results reported here show, both by invitro binding experiments and by crystal structure determination, that the same site binds a conserved segment in the long N-terminal extension of Mps1. It also binds, less tightly, a conserved segment in the N-terminal extension of Ipl1 (yeast Aurora B). Together with results from experiments in yeast cells and from biochemical assays reported in two accompanying papers, the structures and graded affinities identify a communication hub for ensuring uniform bipolar attachment and for signaling anaphase onset.

Medical Cannabis in Malaysia: Supply and Demand on Facebook

The internet has become a key hub for communication and information, including drug-related information. Evidence from other nations suggests that medical cannabis is also available online. Yet little is known about medical cannabis dealing on online services in Malaysia. This study examines the current supply and demand of medical cannabis on Malaysian Facebook Pages. Researchers searched for cannabis Facebook Pages in Malay and English between April and June 2022, using the keywords associated with cannabis and marijuana in popular search engines. The Facebook content, including the posts and users’ responses to supply and demand information for medical cannabis, were screened and analysed. Subsequently, the contents of the Facebook Pages were categorised into five themes: (1) demand for medical cannabis; (2) testimony; (3) supply information; (4) adverse health effects of medical cannabis; and (5) product types and routes of administration. The findings indicate that medical cannabis is available online and searchable via popular search engines, despite being illegal in Malaysia. A total of 46 Facebook Pages related to cannabis were identified in this study, where 13 pages sell medical cannabis directly, and 3 sell both medical and recreational cannabis. In addition to private messages via Facebook Messenger, most pages share contact details. The information on the sampled Facebook Pages reflected the growing demand and illegal sales of medical cannabis in Malaysia via online platforms since 2012. Thus, there is an urgent need for proper regulations and laws to control medical cannabis usage besides protecting patients against potentially harmful medical cannabis online.

Exploring the Impact of In Basket Metrics on the Adoption of a New Electronic Health Record System Among Specialists in a Tertiary Hospital in Alberta: Descriptive Study.

Health care organizations implement electronic health record (EHR) systems with the expectation of improved patient care and enhanced provider performance. However, while these technologies hold the potential to create improved care and system efficiencies, they can also lead to unintended negative consequences, such as patient safety issues, communication problems, and provider burnout. This study aims to document metrics related to the In Basket communication hub (time in In Basket per day, time in In Basket per appointment, In Basket messages received per day, and turnaround time) of the EHR system implemented by Alberta Health Services, the province-wide health delivery system called Connect Care (Epic Systems). The objective was to identify how a newly implemented EHR system was used, the timing of its use, and the duration of use specifically related to In Basket activities. A descriptive study was conducted. Due to the diversity of specialties, the providers were grouped into medical and surgical based on previous similar studies. The participants were further subgrouped based on their self-reported clinical full-time equivalent (FTE ) measure. This resulted in 3 subgroups for analysis: medical FTE <0.5, medical FTE >0.5, and surgical (all of whom reported FTE >0.5). The analysis was limited to outpatient clinical interactions and explicitly excluded inpatient activities. A total of 72 participants from 19 different specialties enrolled in this study. The providers had, on average, 8.31 appointments per day during the reporting periods. The providers received, on average, 21.93 messages per day, and they spent 7.61 minutes on average in the time in In Basket per day metric and 1.84 minutes on average in the time in In Basket per appointment metric. The time for the providers to mark messages as done (turnaround time) was on average 11.45 days during the reporting period. Although the surgical group had, on average, approximately twice as many appointments per scheduled day, they spent considerably less connected time (based on almost all time metrics) than the medical group. However, the surgical group took much longer than the medical group to mark messages as done (turnaround time). We observed a range of patterns with no consistent direction. There does not seem to be evidence of a "learning curve," which would have shown a consistent reduction in time spent on the system over time due to familiarity and experience. While this study does not show how the included metrics could be used as predictors of providers' satisfaction or feelings of burnout, the use trends could be used to start discussions about future Canadian studies needed in this area.

The interplay between membrane viscosity and ligand-binding receptor kinetics in lipid bilayers

Plasma membranes appear as deformable systems wherein molecules are free to move and diffuse giving rise to condensed microdomains (composed of ordered lipids, transmembrane proteins and cholesterol) surrounded by disordered lipid molecules. Such denser and thicker regions, namely lipid rafts, are important communication hubs for cells. Indeed, recent experiments revealed how the most of active signaling proteins co-localize on such domains, thereby intensifying the biochemical trafficking of substances. From a material standpoint, it is reasonable to assume the bilayer as a visco-elastic body accounting for both in-plane fluidity and elasticity. Consequently, lipid rafts contribute to membrane heterogeneity by typically exhibiting higher stiffness and viscosity and by locally altering the bilayer dynamics and proteins activity. A chemo-mechanical model of lipid bilayer coupled with interspecific dynamics among the resident species (typically transmembrane receptors and trasporters) has been recently formulated to explain and predict how proteins regulate the dynamic heterogeneity of membrane. However, the explicit inclusion of the membrane viscosity in the model was not considered. To this aim, the present work enriches the constitutive description of the bilayer by modeling its visco-elastic behavior. This is done through a strain-level dependent viscosity able to theoretically trace back the alteration of membrane fluidity experimentally observed in lipid phase transitions. This provides new insights into how the quasi-solid and fluid components of lipid membrane response interact with the evolution of resident proteins by affecting the activity of raft domains, with effects on cell mechano-signaling.

Enhancing Entrepreneurship Resource Competence through Business Incubator Consultant Certification

This paper presents the results of a certification program aimed at enhancing the competency of entrepreneurship resources through the certification of business incubator consultants. The program, conducted by the Indonesia Management Forum and HR24/7 Communication Hub in Bali, involved participants from various regions across Indonesia. The training sessions covered topics such as advocacy for technology business incubator development, product-market fit analysis, business idea validation, feasibility study preparation, legal and institutional management, company profile creation, access to financing, marketing assistance, business valuation, and financial report preparation. The program culminated in a competency assessment on the third day. The results indicated a high level of satisfaction among participants, highlighting the program's effectiveness in improving their understanding and skills in technology business incubator management. The implications of this program include the potential enhancement of Indonesia's entrepreneurship ecosystem and contributions to the achievement of Sustainable Development Goals.

Next Generation Computing and Communication Hub for First Responders in Smart Cities.

This paper contributes to the development of a Next Generation First Responder (NGFR) communication platform with the key goal of embedding it into a smart city technology infrastructure. The framework of this approach is a concept known as SmartHub, developed by the US Department of Homeland Security. The proposed embedding methodology complies with the standard categories and indicators of smart city performance. This paper offers two practice-centered extensions of the NGFR hub, which are also the main results: first, a cognitive workload monitoring of first responders as a basis for their performance assessment, monitoring, and improvement; and second, a highly sensitive problem of human society, the emergency assistance tools for individuals with disabilities. Both extensions explore various technological-societal dimensions of smart cities, including interoperability, standardization, and accessibility to assistive technologies for people with disabilities. Regarding cognitive workload monitoring, the core result is a novel AI formalism, an ensemble of machine learning processes aggregated using machine reasoning. This ensemble enables predictive situation assessment and self-aware computing, which is the basis of the digital twin concept. We experimentally demonstrate a specific component of a digital twin of an NGFR, a near-real-time monitoring of the NGFR cognitive workload. Regarding our second result, a problem of emergency assistance for individuals with disabilities that originated as accessibility to assistive technologies to promote disability inclusion, we provide the NGFR specification focusing on interactions based on AI formalism and using a unified hub platform. This paper also discusses a technology roadmap using the notion of the Emergency Management Cycle (EMC), a commonly accepted doctrine for managing disasters through the steps of mitigation, preparedness, response, and recovery. It positions the NGFR hub as a benchmark of the smart city emergency service.

Mesocarnivores vary in their spatiotemporal avoidance strategies at communications hubs of an apex carnivore.

Mesocarnivores face interspecific competition and risk intraguild predation when sharing resources with apex carnivores. Within a landscape, carnivores across trophic levels may use the same communication hubs, which provide a mix of risks (injury/death) and rewards (gaining information) for subordinate species. We predicted that mesocarnivores would employ different strategies to avoid apex carnivores at shared communication hubs, depending on their trophic position. To test our prediction, we examined how different subordinate carnivore species in the Santa Cruz Mountains of California, USA, manage spatial overlap with pumas (Puma concolor), both at communication hubs and across a landscape-level camera trap array. We estimated species-specific occurrence, visitation rates, temporal overlap, and Avoidance-Attraction Ratios from camera traps and tested for differences between the two types of sites. We found that mesocarnivores generally avoided pumas at communication hubs, and this became more pronounced when pumas scent-marked during their most recent visit. Coyotes (Canis latrans), the pumas' closest subordinate competitor in our system, exhibited the strongest avoidance at communication hubs. Gray foxes (Urocyon cinereoargenteus) avoided pumas the least, which may suggest possible benefits from pumas suppressing coyotes. Overall, mesocarnivores exhibited various spatiotemporal avoidance strategies at communication hubs rather than outright avoidance, likely because they benefit from information gained while 'eavesdropping' on puma activity. Variability in avoidance strategies may be due to differential predation risks, as apex carnivores often interact more aggressively with their closest competitors. Combined, our results show how apex carnivores trigger complex species interactions across the entire carnivore guild and how trophic position determines behavioral responses and subsequent space use of subordinate mesocarnivores across the landscape.

WITHDRAWN: Ip3r-Grp75-Vdac and Relevant Ca2+ Signaling Regulate Dietary Palmitic Acid-Induced De Novo Lipogenesis by Mitochondria-Associated ER Membrane (MAM) Recruiting Seipin in Yellow Catfish

BackgroundThe mitochondria-associated endoplasmic reticulum membrane (MAM) is the central hub for endoplasmic reticulum and mitochondria functional communication. It plays a crucial role in hepatic lipid homeostasis. However, even though MAM has been acknowledged to be rich in enzymes that contribute to lipid biosynthesis, no study has yet investigated the exact role of MAM on hepatic neutral lipid synthesis. ObjectivesTo address these gaps, this study investigated the systemic control mechanisms of MAM on neutral lipids synthesis by recruiting seipin, focusing on the role of the inositol trisphosphate receptor-1,4,5(Ip3r)-75 kDa glucose-regulated protein (Grp75)-voltage-dependent anion channel (Vdac) complex and their relevant Ca2+ signaling in this process. MethodsTo this end, a model animal for lipid metabolism, yellow catfish (Pelteobagrus fulvidraco), were fed 6 different diets containing a range of palmitic acid (PA) concentrations from 0–150 g/kg in vivo for 10 wk. In vitro, experiments were also conducted to intercept the MAM-mediated Ca2+ signaling in isolated hepatocytes by transfecting them with si-mitochondrial calcium uniporter (mcu). Because mcu was placed in the inner mitochondrial membrane (IMM), si-mcu cannot disrupt MAM’s structural integrity. Results1. Hepatocellular MAM subproteome analysis indicated excessive dietary PA intake enhanced hepatic MAM structure joined by activating Ip3r-Grp75-Vdac complexes. 2. Dietary PA intake induced hepatic neutral lipid accumulation through MAM recruiting Seipin, which activated lipid droplet biogenesis. Our findings also revealed a previously unidentified mechanism whereby MAM-recruited seipin and controlled hepatic lipid homeostasis, depending on Ip3r-Grp75-Vdac-controlled Ca2+ signaling and not only MAM’s structural integrity. ConclusionsThese results offer a novel insight into the MAM-recruited seipin in controlling hepatic lipid synthesis in a MAM structural integrity-dependent and Ca2+ signaling-dependent manner, highlighting the critical contribution of MAM in maintaining hepatic neutral lipid homeostasis.

Development and progress of the National Autopsy Network (NATON)

Autopsies have long been considered the gold standard for quality assurance in medicine, yet their significance in basic research has been relatively overlooked. The COVID-19 pandemic underscored the potential of autopsies in understanding pathophysiology, therapy, and disease management. In response, the German Registry for COVID-19 Autopsies (DeRegCOVID) was established in April 2020, followed by the DEFEAT PANDEMIcs consortium (2020-2021), which evolved into the National Autopsy Network (NATON). DeRegCOVID collected and analyzed autopsy data from COVID-19 deceased in Germany over three years, serving as the largest national multicenter autopsy study. Results identified crucial factors in severe/fatal cases, such as pulmonary vascular thromboemboli and the intricate virus-immune interplay. DeRegCOVID served as acentral hub for data analysis, research inquiries, and public communication, playing avital role in informing policy changes and responding to health authorities. Initiated by the Network University Medicine (NUM), NATON emerged as asustainable infrastructure for autopsy-based research. NATON aims to provide adata and method platform, fostering collaboration across pathology, neuropathology, and legal medicine. Its structure supports aswift feedback loop between research, patient care, and pandemic management. DeRegCOVID has significantly contributed to understanding COVID-19 pathophysiology, leading to the establishment of NATON. The National Autopsy Registry (NAREG), as its successor, embodies amodular and adaptable approach, aiming to enhance autopsy-based research collaboration nationally and, potentially, internationally.

Connectome alterations following perinatal deafness in the cat

Following sensory deprivation, areas and networks in the brain may adapt and reorganize to compensate for the loss of input. These adaptations are manifestations of compensatory crossmodal plasticity, which has been documented in both human and animal models of deafness–including the domestic cat. Although there are abundant examples of structural plasticity in deaf felines from retrograde tracer-based studies, there is a lack of diffusion-based knowledge involving this model compared to the current breadth of human research. The purpose of this study was to explore white matter structural adaptations in the perinatally-deafened cat via tractography, increasing the methodological overlap between species. Plasticity was examined by identifying unique group connections and assessing altered connectional strength throughout the entirety of the brain. Results revealed a largely preserved connectome containing a limited number of group-specific or altered connections focused within and between sensory networks, which is generally corroborated by deaf feline anatomical tracer literature. Furthermore, five hubs of cortical plasticity and altered communication following perinatal deafness were observed. The limited differences found in the present study suggest that deafness-induced crossmodal plasticity is largely built upon intrinsic structural connections, with limited remodeling of underlying white matter.