Cytomegalovirus (CMV) infection is with global distribution and range of 30-100%. CMV infection is the most common congenital viral infection worldwide . The sign of congenital CMV infection encountered most frequently is hearing loss, which wills 12.6% of congenitally infected newborns and congenital CMV infection form 10-20% as a cause of total hearing loss in children. About10% of the live-born infants with congenital CMV infection are symptomatic at birth. Where as an additional 10% of the infected newborns will develop permanent sequelae in the following years. Herpes simplex virus (HSV) is an abundant, enveloped, and double stranded DNA virus, belonging to the family of Herpesviridae transmitted across mucosal membranes and non intact skin, with ability to induce chronic latent infection. Susceptibility to HSV infection is associated with HLA antigens. The virus type incidence is about the same for both HSV-1 and HSV-2 strains, while HSV-2 is the most predominant in recurrent infections. HVS -1 is the common strain in labial herpetic infection, while HSV-2 is the predominant in genital infection. The site of latency is the trigeminal ganglia for labial herpetic infection and lumbosacral ganglia for genital herpetic infection. Changes in sexual behaviors of young adults may partly explain its higher incidence.