Nesting technique may be a nursing skill used ordinarily within the developmental care of low-birth-weight (LBW) infant. Nesting is prepared to maintain the physiological, behavioural and postural stability of preterm infant in which the infant’s hands together near face and feet together by using rolled-up sheets to form oval-shaped nest. Nesting maintains premature infants in a very snug position; modify spontaneous motor activity for skeletal. An experimental study was conducted; the study objectives are to assess the discomfort level of LBW babies in experimental and control groups before and during administration of nesting and to compare the change of pre- and post-discomfort scores between experimental and control groups. In this study, the conceptual framework was adopted based on the general system’s theory by Ludwig von Bertalanffy. In this, a consecutive sampling technique (taking every LBW neonates who met the selection criteria over the specified time period) was used to select 60 LBW neonates who were meeting the sampling criteria. A standardized tool to assess the discomfort level among LBW babies by modified NPASS pain scale was used during data collection. Pre-test was conducted <7 days and post-test was conducted on day after 6 hours in experimental group were administration of nesting; and post-test was conducted on day after 6 hours in control group were without nesting among LBW neonates admitted in the NICU of PBMH, KIMS , Bhubaneswar, Odisha. The discomfort level of LBW neonates in post-test has mean ± SD score 0.67 ± 0.84 in experimental and 4.27 ±0.83 in control group. The major findings of the study revealed that the post mean score in experimental was higher than the post mean score in control group. The study revealed that the post-test score increased significantly. As a calculation, the p-value is lesser than tabulated p-value, so there is a significant deference between control and experimental groups.