Hot Spots Research Articles

Experimental testing of additively manufactured embedded fiber optic smart devices for clean energy applications

Abstract An additively manufactured prototype smart device was created to investigate in-flow temperature distributions using embedded high-definition fiber optic sensors within a component for clean energy systems. The devices were created using Ultrasonic Additive Manufacturing to create a unique embedded pathway within a flow conditioner for the high-definition fiber optic sensors to be placed within. The fibers used allowed for temperature measurements to be taken every 0.65 mm along the fiber. The high-resolution fibers were thermally calibrated enable the 2D reconstruction of the temperature profile in the flow path of the structure. This is due to the temperature-related strain response of the material and strain measurements of the fibers. Hot airflow testing of these devices showed the ability to identify localized temperature differences in the flow. The observed strain response within the smart device had higher strain concentrations in the thicker web regions than in the thinner web regions. These higher strain regions resulted in higher uncertainties for the temperature responses. Further calibration is needed to improve the accuracy of the smart devices, specifically within the inner web structures of a flow straightening component. Further investigations of the devices within flow showed the temperature sensing to be independent of the effects of flow velocity. The devices were able to distinguish temperature differences within single and two-phase flow and showed local sensitivity to the temperature changes with the identification of hot and cold spots. The presented results showed the viability of the smart device for obtaining detailed temperature distributions using common industrial components. Eventually, the goal for these smart devices will be to withstand higher temperature and pressure environments such as those experienced in nuclear, fusion, and concentrated solar energy systems.

Here’s Why Resolution Copper Wants to Mine Oak Flat

Southeastern Arizona’s “Copper Triangle” is a hot spot for high-grade deposits, thanks to ancient magmatic activity.

Myrmecophily among mesostigmatid mites

AbstractAnt nests are biodiversity hot spots, concentrating resources from a wide area that can be exploited by other organisms, known as myrmecophiles. The mite order Mesostigmata includes a wide range of lineages that have become myrmecophiles with many species reliant on ant nests for at least part of their development. The nature of the associations is quite variable, including predators of smaller arthropods in the nest (close to the ancestral lifestyle of these mites), scavengers, kleptoparasites, parasites, and parasitoids. A few mite species show extreme modifications of morphological and/or developmental patterns, others show almost none. Some host specificity is common but one-on-one host specialization is rare or poorly tested. Phoresy on the ants is common, but the target ant caste varies with the goal of phoresy. In general, the diversity of mesostigmatid mites in the nest of a given ant species is affected by habitat conditions along with a range of life history characteristics of the ants, including factors such as body size, colony size, colony founding mode, social parasitism, and nest density. Unfortunately, the life history of the majority of mites associated with ants is still unknown.

Influencing factors of bentonite for the directional electric repair of landfill HDPE membrane leakage in calcium ion solution

The timely repair of high-density polyethylene (HDPE) membrane leakage in landfills is an important means of environmental risk control, which is critical for preventing leachate from polluting groundwater and soil. Electric repair technology is expected to become a hot spot in the leakage repair of HDPE films, because it can solve the issues of complex operation, high costs, and security risks during the operation and closure of landfills. To explore the influence law of various technical factors on the electric repair process, we carried out single factor experiments on the main influencing factors such as the operation time, bentonite concentration and dispersant/bentonite dosage ratio, leakage size, and calcium concentration. We then explored the best technological conditions. The results showed that accumulation at the leakage site possessed a good repair effect with a permeability coefficient of 4.22 × 10−6 cm/s. Furthermore, we observed that the Zeta potential played an important role in the electric repair technology, where the higher the absolute value of the Zeta potential, the faster the electrophoretic migration rate of the bentonite particles, and the lower the permeability coefficient of accumulation. This study may serve as a theoretical basis and offer scientific guidance for the directional electric repair of HDPE membrane leakage during the operating period and after the closure of landfills.

Switchable RDX‐Based Rubberized Explosive with Thermally‐Expandable Microspheres

AbstractImproving the safety of explosive materials through the synthesis of insensitive explosives has been studied extensively. However, little work has focused on creating switchable explosives. A switchable explosive is normally insensitive to detonation, and therefore safe to handle and transport, but can be sensitized when needed to create a functional explosive. Similarly, it may be desired to desensitize an explosive to prevent its function. This study examined the ability to create a switchable 1,3,5‐trinitro‐1,3,5‐triazinane (RDX)‐based rubberized explosive using thermally‐expandable microspheres (TEMs). The addition of TEMs to the explosive formulation allowed for microstructural changes and potential hot spot locations to form as the microspheres expanded. Small voids (less than about 10 μm) are more likely to be critical hot spots when shocked, and likewise larger voids are less likely to ignite successfully (sub‐critical) when shocked. Consequently, both sensitization and desensitization are possible. The rubberized explosive considered here with unexpanded microspheres was unable to sustain a detonation for the size used, but after specific heating followed by cooling to produce small voids, a detonation was achieved. The TEMs addition to the RDX‐based rubberized explosive resulted in an explosive that is detonation insensitive when unheated but becomes a functional explosive after it is sensitized through heating. This paves the way to create insensitive explosive formulations with on‐demand switchable detonation function through the incorporation of thermally‐expandable microspheres. Desensitization was also demonstrated with specific heating of TEMs in an initially detonable explosive charge. Finally, we also demonstrated that deflagration can be affected by heating TEMs.

Analysis of the Morphometric Characteristics of Wadi Rajil in the Azraq Basin using Geographic Information Systems

The study aimed to Analyse the Hydrometric Characteristics of Wadi Rajil basin and assess the flood hazards in the basin using Remote Sensing and Geographic Information Systems Techniques. The study used Models of Digital Visualizations of the basin and processed them using ARC GIS 10.5 and ARC HYDRO TOOLS. The result was that the Hypsometric Coefficient reached (21.4%) of the valley area that was exposed to erosion and (78.6%) of it is still waiting for its turn to erosion, indicating that the valley has reached the stage of youth. The analysis of Hot Spots in the GIS program resulted in negative values for internal Drainage Basins greater than -0.5 extending to the northern and northwestern parts of the basin. It also showed that the flow coefficient exceeds the internal Drainage Coefficient or Leakage. As for the positive values, they are distributed in the southern and southeastern parts, where the (Hot) values prevail and where the leakage coefficient exceeds the Flow Coefficient. We find that the Hot Spots are concentrated in the southeastern parts, which are mostly extended. The Rift and thus the most suitable areas for Groundwater Charging through it.

On the chemistry of sunlight-induced DNA lesions: A perspective on the alkaline chemical-induced reactivities of photo-damaged pyrimidine intra-strand dimers.

Photoexcitation of cellular as well as isolated DNAs upon exposure to the UV portion of sunlight or other UV sources can lead to the covalent dimerization of adjacent intra-strand stacked pyrimidine nucleobase rings (i.e., at 5'-Py-p-Py-3' sites). These modifications generate, in mammalian DNA as well as the DNA of all other forms of life, lesions such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs); and, in bacterial endospores, spore photoproducts (SPs). Importantly, the lesions formed in higher organisms can lead to disease states including cancer. While the formation, structure, and biological outcomes of pyrimidine dimer lesions have been the focus of much research, less has been known about their fundamental chemical properties until recently. Such an understanding of these lesions may lead to novel means to chemically identify and quantitate their presence in the genome. This review is intended to provide an overview of intra-strand pyrimidine dimer lesions derived from 5'-T-p-T sites with a focus on presenting what is currently known about their individual invitro alkaline chemical reactivities. Included here are descriptions of investigations of the DNA lesions CPD, 6-4PP, and SP, and, for comparison, the monomeric pyrimidine lesion 5,6-dihydo-2'-deoxyuridine (dHdU). Of interest, the alkaline hydrolyses of these various lesions are all found to be centered on the loss of aromaticity of a lesion Py ring (T) leading to a carbonyl "hot spot," the focal point of initial hydrolytic attack.

Antibiotic-Mediated Plasmonic Resonance on a Novel Nanopillar Metasurface Array.

This study demonstrates a silicon nanopillar metasurface coupled with localized surface plasmon resonance (LSPR) mediated by the presence of cephalexin antibiotics in solution for biosensing applications. A facile fabrication process was developed to create the metasurface on silicon wafers with a unique resonance signature. The resulting metasurface consists of periodic nanopillars approximately 180 nm in diameter, 210 nm deep, and with a controlled edge-to-edge separation of 200 nm. These dimensions were chosen based on a finite element method simulation that was used to investigate the ideal parameters to produce the desired resonance effect in the metasurface reflection spectra. Optimization of the nanopillar surface properties and the sidewall angle allowed for replication of the simulations. This metasurface was coupled with BSA-coated gold nanospheres (BSANS) to mediate the redshift of peak resonance wavelength values, occurring only in the presence of the antibiotic linker. The device fabricated herein exhibits a significant 22 nm wavelength shift resulting from changes to the local refractive index in the presence of the BSANS-antibiotic coupling. Further enhancement of the binding events is promoted by the LSPR hot spots formed between the nanoparticles and the metasurface allowing for sensitive and real-time detection.

Prevalence and Genetic Diversity of Deer Tick Virus (Powassan Virus, Lineage II) in Ixodes scapularis Ticks in Five Habitats at a Nature Reserve in Southern Maine, United States.

Deer tick virus (DTV), also known as Powassan virus lineage II, is a rising health concern due to increased recognition as a cause of human encephalitis. Since European tick-borne encephalitis virus persists in nature in enzootic foci (i.e., higher prevalence rates in small pockets in nature), we sought to determine whether DTV is also focally maintained in relation to habitat type, to better understand factors leading to human risk of exposure. From 2018 to 2021, questing Ixodes scapularis ticks were collected from five habitats at the Wells National Estuarine Research Reserve (WNERR) in Wells, ME: forest with invasive vegetation in the understory, edge, shrub, forest with native vegetation in the understory, and open field. Deer tick virus prevalence was greater in adult ticks (2.0%) than in nymphs (0.5%). Deer tick virus prevalence in adult ticks collected from forest with invasive vegetation was 3.2% compared to 0 to 1.7% in other habitat types. A hot spot analysis revealed a higher number of infected adults collected per hour on one of the transects located in forest with invasive vegetation. Phylogenetic analysis of 37 full-length DTV genomes sequenced in this study revealed four major clades from the WNERR, and there was high genetic diversity within each transect, suggesting frequent, short-range dispersal between habitats. Analysis of DTV sequences from other New England counties and states also indicated long-distance dispersal to and/or from the WNERR. This study provides preliminary evidence that DTV is focal and that the risk of encountering DTV-infected ticks in forest with invasive vegetation may be greater than in other habitat types.

Curiosity and Digital Stories: Exploring Preschoolers’ Behaviors

<p style="text-align:justify">Given curiosity’s fundamental role in motivation and learning and considering the widespread use of digital stories as educational tools from the preschool age, we pursued measuring preschoolers’ curiosity when interacting with digital stories. Using 129 toddlers and preschoolers as a sample, three groups (one for each class) were given different versions of the same digital story to listen to: interactive, non-interactive, and animated. Toddlers' verbal and nonverbal behaviors were utilized to quantify curiosity as a condition brought on by the app. The participants' verbal and nonverbal behaviors were recorded during the digital reading aloud. Every child's data was encoded at one-minute intervals to examine concurrent behavior, and the results were then compiled. The findings show that interactive presentation formats encourage more touching and language use but less noise production and that interaction and the creative use of hot spots in digital illustrations are key elements in piquing viewers' curiosity while contributing to the strengthening of the engagement to the activity and the cultivation of critical thinking, creativity, and imagination.</p>

SNaPshot minisequencing for SARS CoV 2 Variant Genotyping

Abstract Introduction/Objective The SNaPshot Multiplex System (Thermo Fisher) can investigate up to fifty SNP markers simultaneously by using PCR amplification and subsequent dideoxy single base extension of an unlabeled primer and capillary electrophoresis. After electrophoresis and fluorescence detection, the alleles of a single marker appear as different colored peaks at roughly the same size in the electropherogram plot. The size of the different allele peaks vary slightly due to differences in molecular weight of the dyes. We propose a new set of primers and probes to use this system to differentiate variants of SARs Cov 2 variants. Methods/Case Report SNAPSHOT analysis was performed using the primers designed internally and analysis was done of up to 7 mutation hot spots, which were 417, 4511, 478, 484, 501, 614, and 681. By implementing the algorithm of systems and methods herein with the traces depicted in Figures, true positive and true negative outcomes for the different COVID variants can be performed, based on the highlighted peaks, which are not necessarily the most intense peaks. 10 Positive controls achieved from in stro transcript plasmid was tested then 10 viral RNA obtained through BEI Resources, NIAID was tested after mixed into 30 pooled negative PCR-swab specimens. Genmapper was used for analysis of results. 40 Korean patient samples were tested as well. Results (if a Case Study enter NA) Both In vitro transcript and derived specimens of wild type, alpha, beta, delta, gamma, kappa, omicron, and pirola showed expected results in 78/80 of the specimens. For example,delta B.1.617.2 variant showed 1 = A (green) at Primer 452R-F, 2 = G (blue): Primer 484Q-F, and 3 = A (green) at Primer 614-F. Of note, hetero type was noted in a few of the patient strains but none of the BEI strains and this may be due to a transfromation of the virus and worth investigation. Conclusion The SNaPshot® Multiplex System is a accurate system that may be applied to multiple applications including viral strain anylsis and here we can show how it may be effectively used for SARS-Cov-2 gentotyping. Using this technique, it is possible to analyze more than 50 SNPs distributed throughout the genome in a single multiplex reaction, making it an advantage when compared with traditional sequencing reaction. This is a important study that shows that this technique may be used in multiple field applictions.

Hyperspectral Analysis of Silicon Nanowires Manufactured Through Metal-Assisted Chemical Etching

Abstract This study used hyperspectral imaging to analyze localized near-field interactions between incident electromagnetic waves and silicon nanowire (SiNW) arrays manufactured through catalytic etching of Si wafers for different durations. The results revealed that the unetched upper surface area on Si wafers and reflection of incident light decreased with increasing etching time. A light reflection band peaking at approximately 880 nm was generated from arrays etched for more than 1 h. We used six separate hyperspectral images to analyze the wavelength-dependent spatial optical responses of the fabricated SiNW arrays. The images revealed hot spots of light reflection from unetched Si surfaces in the wavelength range of 470–750 nm and a resonant peak at 880 nm for a photonic crystal derived from a random SiNW array. Accordingly, hyperspectral imaging enables the assessment of localized optical responses of SiNW arrays, which can then be optimized to cater to various applications.

Quantitative Analysis about the Spatial Heterogeneity of Water Conservation Services Function Using a Space–Time Cube Constructed Based on Ecosystem and Soil Types

Precisely delineating the spatiotemporal heterogeneity of water conservation services function (WCF) holds paramount importance for watershed management. However, the existing assessment techniques exhibit common limitations, such as utilizing only multi-year average values for spatial changes and relying solely on the spatial average values for temporal changes. Moreover, traditional research does not encompass all WCF values at each time step and spatial grid, hindering quantitative analysis of spatial heterogeneity in WCF. This study addresses these limitations by utilizing an improved water balance model based on ecosystem type and soil type (ESM-WBM) and employing the EFAST and Sobol’ method for parameter sensitivity analysis. Furthermore, a space–time cube of WCF, constructed using remote-sensing data, is further explored by Emerging Hot Spot Analysis for the expression of WCF spatial heterogeneity. Additionally, this study investigates the impact of two core parameters: neighborhood distance and spatial relationship conceptualization type. The results reveal that (1) the ESM-WBM model demonstrates high sensitivity toward ecosystem types and soil data, facilitating the accurate assessment of the impacts of ecosystem and soil pattern alterations on WCF; (2) the EHSA categorizes WCF into 17 patterns, which in turn allows for adjustments to ecological compensation policies in related areas based on each pattern; and (3) neighborhood distance and the type of spatial relationships conceptualization significantly impacts the results of EHSA. In conclusion, this study offers references for analyzing the spatial heterogeneity of WCF, providing a theoretical foundation for regional water resource management and ecological restoration policies with tailored strategies.

Genetic and molecular regulation of fruit development in cucumber.

Fruit development can be generally classified into a set of biologically sequential stages including fruit initiation, growth, and ripening. Cucumber, a globally important vegetable crop, displays two important features during fruit development: parthenocarpy at fruit initiation and prematurity at harvest for consumption. Therefore, fruit growth plays essential role for cucumber yield and quality formation, and has become the research hot spot in cucumber fruit development. Here, we describe recent advances in molecular mechanisms underlying fruit growth in cucumber, include key players and regulatory networks controlling fruit length variation, fruit neck elongation, and locule development. We also provide insights into future directions for scientific research and breeding strategies in cucumber.

Spatial variations and predictors of overweight/obesity among under-five children in Ethiopia: A geographically weighted regression analysis of the 2019 Ethiopian Mini Demographic and Health Survey.

Overweight/ obesity among under-five children is an emerging public health issue of the twenty-first century. Due to the quick nutritional and epidemiological change, non-communicable diseases, premature death, disability, and reproductive disorders have grown in low-income countries. Besides, little attention has been given. Therefore, we aimed to explore spatial variations and predictors of overweight/obesity among under-five children in Ethiopia using a geospatial technique. A total weighted sample of 3,609 under-five children was included in the study. A cross-sectional study was conducted using a nationally representative sample of the 2019 Ethiopia Mini Demographic and Health Survey data set. ArcGIS version 10.8 was used to explore the spatial variation of obesity. SaTScan version 9.6 software was used to analyze the spatial cluster detection of overweight/obesity. Ordinary least square and geographically weighted regression analysis were employed to assess the association between an outcome variable and explanatory variables. A p-value of less than 0.05 was used to declare it statistically significant. The spatial distribution of overweight/obesity among under-five children in Ethiopia was clustered (Global Moran's I = 0.27, p-value<0.001). The significant hot spot areas or higher rates of childhood obesity, were found in Southern Amhara, Northwest Somalia, Border of Harari, central Addis Ababa, Eastern SNNPR, and Northwestern Oromia region. In spatial SaT Scan analysis, 79 significant clusters of overweight/obesity were detected. The primary clusters were located in SNNPR, Oromia, and Addis Ababa (RR = 1.48, LLR = 31.40, P-value < 0.001). In the geographically weighted regression analysis, urban residence, cesarean section, rich households, and female children were statistically significant predictors. Overweight or obesity among under-five children show spatial variations across Ethiopian regions. GWR analysis identifies cesarean section, wealth index, urban residence, and child sex as significant predictors. The Ministry of Health and Ethiopian Public Health Institute should target regions with these contributing predictors, promoting localized physical education, health education campaigns, and ongoing community monitoring to encourage active lifestyles and reduce sedentary behaviors among children.

Fast and on-site detection of fenthion in rice using core-shell Au@Ag nanoparticles and a portable Raman spectrometer

The residue of pesticide fenthion is a common issue in food safety, and how to conveniently detect it is a challenge in the food industry. Therefore, combined with a portable Raman spectrometer, a surface enhanced Raman spectroscopy (SERS) method based on a high-performance substrate Au@AgNPs had been designed for the rapid and sensitive detection of fenthion. Au@AgNPs can be induced to generate more hot spots to improve SERS signals because of their core-shell structure. The quantitative detection of fenthion was achieved under the optimal conditions: pH 7.0, 10−3 M CaCl2, 70 % Au@AgNPs concentration, and 4 min of incubation time. The results showed that the method had a wider detection range of 0.1–100 mg/L, a low detection limit (LOD) of 0.036 mg/L, excellent anti-interference ability, and reproducibility. In addition, the method was successfully validated with the actual sample rice. Therefore, the method had the advantages of being fast, on-site, and easy to use, which is useful for promoting its application.

Primary and secondary prevention of postpartum depression

Pregnancy is one of the important life events in a woman's life, which in the face of pregnancy, childbirth and breastfeeding process, maternal psychology and physiology will have obvious changes, among which postpartum depression is more common. Postpartum depression (PPD) is a mental syndrome with obvious depressive symptoms or typical depressive episodes during the puerperal period. Its etiology is complex, with sleepiness, gloomy expression, crying and other symptoms in clinic, and even some patients will have suicidal tendencies, which seriously endangers maternal physical and mental health. In recent years, the adverse events caused by postpartum depression have attracted more and more social attention, and postpartum women's mental health has become a hot spot in clinical research. Clinical workers should improve the awareness of postpartum depression, and strengthen the maternal mental health screening, so as to detect psychological abnormalities as early as possible and give timely intervention measures. In view of the high incidence of postpartum depression, it is very important to establish a sound mental health service system for pregnant women. This paper will analyze the high risk factors of PPD summarized the targeted primary prevention and secondary prevention, and proposed prevention strategies before and after the onset of postpartum depression, respectively, to provide theoretical basis for effectively preventing the occurrence of postpartum depression or delaying the progression of postpartum depression.

Simulating controlled drainage and hydrological connections in a cultivated peatland field

AbstractCultivated peatlands are increasingly regarded as hot spots due to climate change and other environmental concerns. Flexible water management, such as controlled drainage, is proposed to optimize cultivation and reduce environmental risks in peatland fields. The hydrological and environmental implications of controlled drainage depend on site‐specific variables, and it is unclear how controlled drainage should be implemented in various conditions. Simulation models are a promising approach to systemically study the field hydrology, as models can capture the complete water balance, which is difficult through experimental studies alone. We calibrated and validated the spatially distributed model FLUSH to describe the hydrology of a field block with a shallow peat cover and controlled drainage in central western Finland. The objectives were to analyze the hydrological effects of controlled drainage and detect hydrological connections between the field and an adjacent upslope forest area. The results showed how inflow from the forest can induce high observed drain discharge but impacted the block groundwater tables only in the proximity of the forest (distance &lt;25 m). The effect of controlled drainage on groundwater tables was on average 0.15 m and seasonally varying. Controlled drainage reduced drain discharge, and the reduction was larger with the forest area included in the model. While controlled drainage effects on groundwater levels and soil moisture were insensitive to groundwater influxes from adjacent areas, the water balance impact highlights the role of hydrological connections in the hydrology of cultivated peatlands under controlled drainage.

Lagged effects of climate factors on bacillary dysentery in western China.

Evidence has shown that the incidence of bacillary dysentery (BD) is associated with climatic factors. However, the lagged effects of climatic factors on BD are still unclear, especially lacking research evidence from arid and semi-arid regions. Therefore, this study aims to add new insights into this research field. Spatial autocorrelation, time series analysis and spatiotemporal scans were used to perform descriptive analyses of BD cases from 2009 to 2019. On the basis of monthly data from 2015 to 2019, multivariable distributed lag non-linear models were used to investigate the lagged effects of climatic factors on BD. The hot spots for BD incidence are gradually decreasing and becoming increasingly concentrated in the southern part of Gansu Province. The maximum cumulative relative risks for monthly average temperature, sunshine duration, average relative humidity and precipitation were 3.21, 1.64, 1.55 and 1.41, respectively. The lagged effects peaked either in the current month or with a 1-month lag, and the shape of the exposure-response curve changed with the increase in maximum lag time. After stratification by per capita gross domestic product, there were differences in the effects. Climatic factors can influence the incidence of BD, with effects varying across different lag times. It is imperative to vigilantly track the disparities in the incidence of BD attributable to economic factors.

Clinical value of SUVpeak-to-tumor centroid distance on FDG PET/CT for predicting neoadjuvant chemotherapy response in patients with breast cancer

BackgroundSince it has been found that the maximum metabolic activity of a cancer lesion shifts toward the lesion edge during cancer progression, normalized distances from the hot spot of radiotracer uptake to tumor centroid (NHOC) and tumor perimeter (NHOP) have been suggested as novel F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters that can reflect cancer aggressiveness. This study aimed to investigate whether NHOC and NHOP parameters could predict pathological response to neoadjuvant chemotherapy (NAC) and progression-free survival (PFS) in breast cancer patients.MethodsThis study retrospectively enrolled 135 female patients with breast cancer who underwent pretreatment FDG PET/CT and received NAC and subsequent surgical resection. From PET/CT images, normalized distances of maximum SUV and peak SUV-to-tumor centroid (NHOCmax and NHOCpeak) and -to-tumor perimeter (NHOPmax and NHOPpeak) were measured, in addition to conventional PET/CT parameters.ResultsOf 135 patients, 32 (23.7%) achieved pathological complete response (pCR), and 34 (25.2%) had events during follow-up. In the receiver operating characteristic (ROC) curve analysis, NHOCmax showed the highest area under the ROC curve value (0.710) for predicting pCR, followed by NHOCpeak (0.694). In the multivariate logistic regression analysis, NHOCmax, NHOCpeak, and NHOPmax were independent predictors for pCR (p < 0.05). In the multivariate survival analysis, NHOCpeak (p = 0.026) was an independent predictor for PFS along with metabolic tumor volume, with patients having higher NHOCpeak showing worse PFS.ConclusionNHOCpeak on pretreatment FDG PET/CT could be a potential imaging parameter for predicting NAC response and survival in patients with breast cancer.