Hot Cell Research Articles

Lightweight image denoising method for feature-based visual SLAM in γ radiation environments

In the γ radiation environments, high-energy photons impact image sensor pixels and induce speckle noise in the scene image, which influences the accuracy of feature detection and matching in the visual Simultaneous Localization and Mapping (SLAM) algorithms. To mitigate these effects, this paper presents a lightweight image denoising method based on super-neighborhood down-sampling. Firstly, the super-neighborhood down-sampling strategy is used to split the speckle noise in the camera images into isolated point noises in the sub-image sets. Secondly, these isolated flickering point noises are removed by the detection-based median filter. Finally, the denoised scene image is reconstructed by the super-neighborhood up-sampling. Extensive experiments were performed on the radiation environment datasets that were captured by the camera inside the Cobalt-60 hot cell. The results show that the proposed method can effectively filter out the speckle radiation noise induced by γ rays, significantly improve the quality of features and feature matching rate, and improve the performance of ORB-SLAM3, the state-of-the-art feature-based SLAM algorithm, in radiation environments.

Simulation and Performance of 99Mo/99mTc Radioisotope Separation by Modified Extraction Method

Abstract Technetium-99m (99mTc) is a nuclide in nuclear medicine, commonly derived as a decay product from molybdenum-99 (99Mo). Unfortunately, Japan and Indonesia rely entirely on imports for their 99Mo/99mTc supply. This study aims to determine the distribution coefficient (Kd) for the 99Mo/99mTc production process and assess the efficiency of Methyl Ethyl Ketone (MEK) as a solvent in the extraction process. The method Initial tests using Rhenium (Re) as a substitute for 99mTc, conducted in collaboration with the Japan Atomic Energy Agency (JAEA), revealed optimal conditions: a standing time of 5 to 15 minutes, a mixing time of 3 minutes with a motor speed of 250 rpm, and a MEK volume exceeding 20 ml. These conditions yielded a Re extraction efficiency exceeding 85.14%, with a Re elution yield of up to 98.73%. These findings served as a database for experiments involving 99Mo/99mTc conducted at the National Research and Innovation Agency (BRIN). In hot experiments, the 99mTc recovery rate through MEK exceeded 100%, while the elution process achieved a recovery rate of 97.81%. Through simulation and facility enhancements in the hot cell, the 99mTc extraction recovery increased to 44.86%, and elution recovery ranged from 90.62%. From the calculation results, the distribution coefficient value database (Kd-99mTc) was 0.45. Radionuclide and radiochemistry purity of the 99mTc solution were assessed using the Gamma Spectrometer and TLC Scanner, resulting in purity of 99.90% and 99.80%, respectively. These results underscore the potential for domestic production 99mTc, reducing reliance on imports.

The Sustainable Development Trend, Progress and Challenge of Solar Cells

The current development of solar cells indicates that this field is experiencing rapid technological progress and market expansion. Various types of solar cells, from traditional silicon-based ones to emerging thin-film, dye-sensitized, perovskite, and organic solar cells, are constantly being developed to improve efficiency, reduce costs, and meet different application needs. While silicon-based solar cells remain one of the most mainstream types on the market, researchers are exploring third-generation photovoltaic devices such as multi-junction series cells, intermediate band gap cells, multiple exciton-generating cells hot carrier cells thermal-light photovoltaic solar cells to further bolster efficiency and reduce costs. These new solar cell technologies theoretically offer higher conversion efficiency and are anticipated to replace traditional silicon-based ones in the future. Advancements in the technology of solar cells mainly involve continuous progress and innovation in materials' development structural design manufacturing processes-from early silicon-based designs to today's thin-film arrays. Each generation is developed with the goal improving efficiency lowering costs; subsequently leading to recent developments in organic and perovskite arrays currently under exploration creating a final product at a lower price. At present, current attention within development primarily lies towards material components advancement efficiency maximization. Cost reduction strategies large scale production Although faced with certain obstacles; through consistent research proving their overwhelming effectiveness; implications for widespread use suggest performance. Overall prospects within Solar energy appear limitless.

Extending the defect tolerance of halide perovskite nanocrystals to hot carrier cooling dynamics

Defect tolerance is a critical enabling factor for efficient lead-halide perovskite materials, but the current understanding is primarily on band-edge (cold) carriers, with significant debate over whether hot carriers can also exhibit defect tolerance. Here, this important gap in the field is addressed by investigating how intentionally-introduced traps affect hot carrier relaxation in CsPbX3 nanocrystals (X = Br, I, or mixture). Using femtosecond interband and intraband spectroscopy, along with energy-dependent photoluminescence measurements and kinetic modelling, it is found that hot carriers are not universally defect tolerant in CsPbX3, but are strongly correlated to the defect tolerance of cold carriers, requiring shallow traps to be present (as in CsPbI3). It is found that hot carriers are directly captured by traps, instead of going through an intermediate cold carrier, and deeper traps cause faster hot carrier cooling, reducing the effects of the hot phonon bottleneck and Auger reheating. This work provides important insights into how defects influence hot carriers, which will be important for designing materials for hot carrier solar cells, multiexciton generation, and optical gain media.

Radionuclide characterization and handling strategy of irradiated Fission Product Material (FPM) capsule waste from molybdenum-99 production

Abstract Irradiated FPM Capsule waste is one of the types of radioactive waste generated from Molybdenum-99 (99Mo) production. This 99Mo is a 99mTc parent radionuclide that is used for the diagnosis of human organ disorders. In its production, the capsule is used for the emplacement of uranium target for irradiation in the GA Siwabessy Reactor. Since the beginning of production until now, the irradiated FPM capsules waste are still being stored in the hot cells because no data on their characteristics and handling systems that are necessary for their treatment. However, long-term storage of the FPM capsules waste in the hot cells shall be avoided because it can disrupt the production process of 99Mo and pose radiation risk to workers. The objectives of this research are to characterize radionuclides composition in the FPM capsule waste and identify its appropriate handling system. The radionuclides characterization was carried out using ORIGEN 2.1 software whereas the selection of the handling system was based on the suitability or modification of the available facilities at Radioactive Waste Management Installation (RWMI)-BRIN. The characterization results show that up to a decay time of 50 years, an FPM capsule waste contains activation product radionuclides such as 55Fe, 59Ni, and 63Ni with a total specific activity of 7.11x106 Bq/g. Three FPM capsule waste handling systems were identified that can be implemented at the RWMI facility, namely by using a 350 -liter concrete shell and then storing in an interim storage for low and intermediate-level waste, using a 60-liter stainless-steel canister which is then stored in the interim storage pit for high-level waste, or by modifying the interim storage pit for high-level waste. Radionuclide characterization and appropriate handling systems are required for the safe management of irradiated FPM capsule waste. This FPM capsule waste management is important for human and environmental protection.

Application of Strain Engineering in Solar Cells.

Solar cells represent a promising innovation in energy storage, offering not only exceptional cleanliness and low cost but also a high degree of flexibility, rendering them widely applicable. In recent years, scientists have dedicated substantial efforts to enhancing the performance of solar cells, aiming to drive sustainable development and promote clean energy applications. One approach that has garnered significant attention is strain engineering, which involves the adjustment of material microstructure and organization through mechanical tensile or compressive strain, ultimately serving to enhance the mechanical properties and performance stability of materials. This paper aims to provide a comprehensive review of the latest advancements in the application of strain engineering in solar cells, focused on the current hot research area-perovskite solar cells. Specifically, it delves into the origins and characterization of strain in solar cells, the impact of strain on solar cell performance, and the methods for regulating stable strain. Furthermore, it outlines strategies for enhancing the power conversion efficiency (PCE) and stability of solar cells through strain engineering. Finally, the paper conducts an analysis of the challenges encountered in the development process and presents a forward-looking perspective on further enhancing the performance of solar cells through strain engineering.

Shielding design and analysis of the hot cell used to produce fission molybdenum-99

Molybdenum-99 is a critical radioisotope for producing diagnostic radiopharmaceuticals labeled by technetium-99m. In this study, the shielding of hot cells used in radiochemical process facilities for industrial 99Mo production via fission of domestic LEU targets was investigated. A calculation method based on MCNP6 simulations was proposed and evaluated by some experimental data. The results showed that the calculated dose rate values should be multiplied by 1.3 from a conservative point of view and then values compared with the permissible dose rate limits. The ISODOSE graphs showed that although a one-layer hot cell with Barite concrete (BA) walls of 80 cm is not enough for radiation-safe work on a hot batch, a one-layer hot cell of BA with 90 cm walls, two-layer BA(80 cm) + Lead(3 cm) and BA(80 cm) + Carbon steel (CS) (4.3 cm) and three-layer BA(80 cm) + CS(1.4 cm) + Lead(2 cm) could be suitable options.

Design and Construction of a Radiochemistry Laboratory and cGMP-Compliant Radiopharmacy Facility.

The establishment of a compliant radiopharmacy facility within a university setting is crucial for supporting fundamental and preclinical studies, as well as for the production of high-quality radiopharmaceuticals for clinical testing in human protocols as part of Investigational New Drug (IND) applications that are reviewed and approved by the U.S. Food and Drug Administration (FDA). This manuscript details the design and construction of a 550 ft2 facility, which included a radiopharmacy and a radiochemistry laboratory, to support radiopharmaceutical development research and facilitate translational research projects. The facility was designed to meet FDA guidelines for the production of aseptic radiopharmaceuticals in accordance with current good manufacturing practice (cGMP). A modular hard-panel cleanroom was constructed to meet manufacturing classifications set by the International Organization of Standardization (ISO), complete with a gowning room and an anteroom. Two lead-shielded hot cells and two dual-mini hot cells, connected via underground trenches containing shielded conduits, were installed to optimize radioactive material transfer while minimizing personnel radiation exposure. Concrete blocks and lead bricks provided sufficient and cost-effective radiation shielding for the trenches. Air quality was controlled using pre-filters and high-efficiency particulate air (HEPA) filters to meet cleanroom ISO7 (Class 10,000) standards. A laminar-flow biosafety cabinet was installed in the cleanroom for preparation of sterile dose vials. Noteworthy was a laminar-flow insert in the hot cell that provided a shielded laminar-flow sterile environment meeting ISO5 (class 100) standards. The design included the constant control and monitoring of differential air pressures across the cleanroom, anteroom, gowning room, and controlled research space, as well as maintenance of temperature and humidity. The facility was equipped with state-of-the-art equipment for quality control and release testing of radiopharmaceuticals. Administrative controls and standard operating procedures (SOPs) were established to ensure compliance with manufacturing standards and regulatory requirements. Overall, the design and construction of this radiopharmacy facility exemplified a commitment to advancing fundamental, translational, and clinical applications of radiopharmaceutical research within an academic environment.

Optical storage of circular airy beam in atomic vapor

Abstract The realization of quantum storage of spatial light field is of great significance to the construction of high-dimensional quantum repeater. In this paper, we experimentally realize the storage and retrieval of circular Airy beams (CABs) by using the Λ-type three-level energy system based on the electromagnetically induced transparency in a hot rubidium atomic vapor cell. The weak probe beam field is modulated with phase distribution of CABs by a spatial light modulator. We store the probe circular Airy beam (CAB) into the rubidium atomic vapor cell and retrieve it after the demanded delay. We quantitatively analyze the storage results and give corresponding theoretical explanations. Moreover, we investigate the autofocusing and self-healing effect of the retrieved CAB, which indicates that the properties and beam shape of CAB maintain well after storage. Our work will have potential applications in the storage of high-dimensional quantum information, and is also useful for improving the channel capacities of quantum internet.

Augmentation of hot cell facility for pyro-process of irradiated metal fuels

Hot cells with an inert atmosphere are used for handling air-sensitive, hygroscopic, and radioactive materials like mixed carbide fuels and for pyro-processing metallic fuels. Pyro-processing of spent metal fuels was based on the electrochemical recovery of actinides in high-temperature molten salts (LiCl-KCl eutectic with 58.5 mol.% LiCl). To demonstrate the remote operation feasibility of the electro-refining process of irradiated U-6 wt% Zr inside hot cells and also to study the process parameters, a pilot scale (∼100 g) pyro-process facility was set up in one of our hot cells. For this purpose, the existing hot cell facility was augmented with necessary modifications and customized to the experimental needs. This paper discusses in detail the augmentation works carried out on the existing facility to facilitate the remote operation of electro-refining of irradiated metallic fuels.

Zoning Assessment of dose Limits in the Hot Cells Building Used for the Fission-Based 99Mo Production

Zoning Assessment of dose Limits in the Hot Cells Building Used for the Fission-Based 99Mo Production

High temperature nanoindentation of (U,Ce)O2 compounds

Continuing to refine our knowledge of the evolving mechanical properties of nuclear fuel over the entire fuel service cycle is necessary to understand the pellet-clad mechanical interaction that occurs in the fuel rods during the operation. A challenge with measuring the mechanical properties of irradiated fuels is their high levels of radioactivity that usually require the use of hot cells making testing time consuming and expensive. Nanoindentation based techniques can be employed on minute volumes of material to measure mechanical properties, including Young’s modulus, hardness, and creep stress exponents. Increasing the mixed oxide fuels mechanical properties database through a variety of testing techniques should enhance modelers’ abilities to predict failure mechanisms in the fuel/clad interface. A current challenge to testing mixed oxide fuels is the plutonium component in the fuel. Mixed fluorite type oxides with ceria (CeO2) can be used as a surrogate for mixed oxide fuels. In this study, (U,Ce)O2 solid solutions samples are used to develop elevated temperature nanoindentation and nanoindentation creep testing methods for use on mixed oxide fuels. Nanoindentation testing was performed on 3 separate (Ux-1,Cex)O2 compounds ranging from x equals 0.1 to 0.3 in equal steps at temperatures up to 800 °C: their Young’s modulus, hardness, and creep stress exponents were evaluated. The Young’s modulus decreases in the expected linear manner while the hardness decreases in the expected exponential manner. The nanoindentation creep experiments at 800 °C give stress exponent values, n = 4.7–6.9, that suggests dislocation motion as the deformation mechanism.

Modulating hot carrier cooling and extraction with A-site organic cations in perovskites.

Hot carrier solar cells could offer a solution to achieve high efficiency solar cells. Due to the hot-phonon bottleneck in perovskites, the hot carrier lifetime could reach hundreds of ps. Such that exploring perovskites could be a good way to promote hot carrier technology. With the incorporation of large organic cations, the hot carrier lifetime can be improved. By using ultrafast transient spectroscopy, the hot carrier relaxation and extraction kinetics are measured. From the transient kinetics, 2-phenyl-acetamidine cation based perovskites exhibit the highest initial carrier temperature, longest carrier relaxation, and slowest hot carrier relaxation. Such superior behavior could be attributed to reduced electron-phonon coupling induced by lattice strain, which is a result of the large organic cation and also a possible surface electronic state change. Our discovery exhibits the potential to use large organic cations for the use of hot carrier perovskite solar cells.

An extension of NASCA for SDDR analysis of mobile activated components with global variance reduction

During the plasma operation period of fusion reactor facilities, neutrons generated by DT reaction can penetrate deeply into structures and induce strong activation. Highly activated components have to be transferred from the on-load position to the hot cell for the purpose of maintenance. This movement produces a high-dose field, originating from the mobile radiation source, which could affect the functionality of important devices or pose risks to the workers. Therefore, it is imperative to compute the shutdown dose rate (SDDR) maps while transporting activated components in the facility and develop an optimized solution for this calculation process. In this study, we established a new extension of the NASCA method combined with the OTF GVR method to compute SDDR maps. NASCA-OTF is a method developed based on the shutdown dose simulation code NASCA to ensure automatic modification of the geometry structure on the fly. In the meantime, it uses OTF method for speeding up the Calculation. Thus, this modified method produces convergent SDDR maps corresponding to different positions of activated components within a single Monte Carlo (MC) simulation. The NASCA-OTF was verified by comparison with R2S method through benchmark analysis. The method was also used for SDDR analysis of the mobile blanket sector for the China Fusion Engineering Test Reactor (CFETR), and the results indicated that the NASCA-OTF is feasible for computing the SDDR resulting from the movement of activated components.

Wall-collision effect on optically polarized atoms in small and hot vapor cells

Wall-collision effect on optically polarized atoms in small and hot vapor cells

Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells

Abstract Metal fuels are considered as the promising candidates for future fast breeder reactors. Pyro-chemical reprocessing is the ideal method for reprocessing spent metallic fuels due to the inherent process advantages. Electrorefining run was demonstrated in a hot cell facility with irradiated U-6 wt% Zr alloy at 500 °C using LiCl–KCl eutectic melt. In order to understand the behavior of the actinides and various fission products during high-temperature electrolysis, various process streams, viz., irradiated metal alloy fuel, the eutectic salt, and the cathode deposit were analyzed for the uranium, plutonium, and other fission product contents. Various methods employed for characterizing the process streams and the behaviors of some of the fission products during the electrolysis process are highlighted. The major gamma emitting radionuclides present in the irradiated fuel were 106Ru, 125Sb, 134Cs, 137Cs, 144Ce, and 154Eu. During electrorefining, cesium, cerium and europium were oxidized and dissolved in the molten media, whereas ruthenium and antimony remained in the anode basket. A minor contamination of zirconium was found in the cathode deposit.

Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients.

To test the hypothesis that neoadjuvant chemoradiotherapy (NACRT) is more effective against hot esophageal squamous cell carcinoma (ESCC) and that it may upregulate tumor immunogenicity. There have been several recent reports showing the efficacy of immune check-point inhibitors (ICIs) against esophageal cancer, especially immunologically hot tumors. In addition, several studies have suggested that chemotherapy and radiotherapy may convert cold tumors to hot tumors. Of 105 ESCC patients who underwent surgery after NACRT between 2010 and 2018 at our hospital, 99 whose biopsy tissue samples were obtained were enrolled. Based on immunohistochemical analysis, tumors that were FOXA1 (+) and/or EYA2 (+) were defined as hot tumors, others were cold tumors. We then investigated the association between tumor immunogenicity and clinicopathological features. The 29 patients with hot tumors before NACRT had a significantly better 5-year disease-specific survival (DSS) rate than the remaining 70 patients with cold tumors (85% vs 64%; P = 0.036). In a multivariate analysis, tumor immunogenicity was a significant independent predictor of DSS. Of 68 patients without a pathological complete response (non-pCR) in their primary tumor, 51 (75%) had hot tumors after NACRT. Moreover, 75% (36/48) of tumors that were cold before NACRT were converted to hot tumors after NACRT. Patients with hot ESCC tumors treated with NACRT plus esophagectomy had a better prognosis than those with cold tumors. NACRT upregulated cold tumor immunogenicity to hot tumors, suggesting NACRT may increase the sensitivity of ESCC to adjuvant ICIs.

Strong Dimensional and Structural Dependencies of Hot Carrier Effects in InGaAs Nanowires: Implications for Photovoltaic Solar Cells.

III-V nanowire structures are among the promising material systems with applications in hot carrier solar cells. These nanostructures can meet the requirements for such photovoltaic devices, i.e., the suppression of thermalization loss, an efficient hot carrier transport, and enhanced photoabsorption thanks to their unique one-dimensional (1D) geometry and density-of-states. Here, we investigate the effects of spatial confinement of photogenerated hot carriers in InGaAs-InAlAs core-shell nanowires, which presents an ideal class of hot carrier solar cell materials due to its suitable electronic properties. Using steady-state photoluminescence spectroscopy, our study reveals that by increasing the degree of spatial confinement and Auger recombination, the effects of hot carriers increase, which is in good agreement with theoretical modeling. However, for thin nanowires, the temperature of hot carriers decreases as the effects of crystal disorder increase. This observation is confirmed by probing the extent of the disorder-induced Urbach tail and linked to the presence of a higher density of stacking defects in the limit of thin nanowires. These findings expand our knowledge of hot carrier thermalization in nanowires, which can be applied for designing efficient 1D hot carrier absorbers for advanced-concept photovoltaic solar cells.

Temperature-dependent ultrafast hot carrier dynamics in the dilute bismide alloy GaSb1−xBix (x ≾ 0.4%)

We report temperature-dependent hot carrier dynamics in liquid-phase epitaxy-grown GaSb1−xBix epilayers with dilute amounts of Bi (x ≾ 0.4%). Degenerate pump–probe (λ = 800 nm) transient reflectivity (PPTR) was used to investigate the carrier dynamics in the epilayers. The PPTR signal consists of two transient processes (fast and slow) at all temperatures for all epilayers. The fast, hot carrier relaxation time, which is attributed to the combined effect of intervalley scattering and thermalization of carriers below cryogenic temperatures (<100 K), is observed to increase with an increase in temperature (≈0.8–2 ps at 6.6 K and ≈4–5 ps at 300 K). However, at higher temperatures (>100 K), the interband CHSH-Auger recombination process affects the band-to-band recombination, leading to an increase in the slower decay time. The findings offer crucial insights for optimizing GaSbBi for hot carrier solar cell applications.

Abstract B063: Tertiary lymphoid organogenesis and lymphocyte activation in human organ chips

Abstract The rates of tertiary lymphoid organ (TLO) formation in pancreatic cancer are very low but patients with TLO have dramatically better survival rates. Our goal is to understand how pancreatic cancer suppresses TLO so that we can improve patient survival and reduce recurrence. We integrated human cell lines from pancreatic and lung cancer with either high or low PDL1/L2 expression into our previously described lymphoid follicle (LF) chip (Goyal et al., Adv. Sci, 2022), where peripheral blood mononuclear cells are induced to form 3D TLO-like structures. The hot lung cancer cell line, which expressed high levels of PDL1/L2 and a “hot” phenotype in published murine studies, produced a high levels of cytokines and stimulated increased TLO formation in the LF chip. In contrast, the cold lung and pancreatic cell lines did not induce the cytokine signature or TLOs. Importantly, TLO formation correlated with increased B cell activation, anti-tumor CD8 activity and tumor cell death. We have coupled this in vitro study with analysis of the pancreatic cancer transcriptome from the Cancer Genome Atlas to identify therapeutic targets to promote TLO formation in pancreatic cancer. In ongoing studies, we are assessing the functionality of the lung cancer TLO in vitro and in vivo and identifying therapeutics that may improve TLO formation in pancreatic cancer. Citation Format: Yunhao Zhai, Pranav Prabhala, Lucas Barck, Min Wen Ku, Aditya Patil, Viktor Horvath, Russell A. Gould, Donald E. Ingber, Girija Goyal. Tertiary lymphoid organogenesis and lymphocyte activation in human organ chips [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Pancreatic Cancer; 2023 Sep 27-30; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(2 Suppl):Abstract nr B063.