Grounded in the conservation of resources (COR) theory, this research investigates the role of cultural intelligence (CQ) on the level of burnout experienced by Chinese expatriates working in Thailand. In particular, in light of the collectivist characteristics of Thai culture, the study proposes that coworker support of host country nationals (HCN) is the mediator that explains the association between CQ and burnout. Moreover, given the feminine and power distance characteristics of Thai culture, this research explores whether the effect of CQ on HCN coworker support is moderated by gender and job position of Chinese expatriates. Survey data was gathered from 413 Chinese expatriates working for 15 Chinese subsidiaries in Thailand. Partial least squares structural equation modeling was used for data analysis. The analysis supports the mediating effect of HCN coworker support on the link between CQ and burnout. Moreover, moderating effect analysis indicates that the positive association between CQ and HCN coworker support is stronger for male Chinese expatriates and those in lower job positions.