Introduction: The hospital information system is an electronic tool that collects, classifies, stores and retrieves the financial, administrative and clinical information of patients using computer capabilities and provides them to decision makers at any place and time. The present study was conducted with the aim of evaluating the acceptance of the hospital information system from the point of view of the users of teaching hospitals of Ahvaz University of Medical Sciences. Method: The present study is descriptive observational. The samples included 270 users of teaching hospitals in Ahvaz. Sampling was done randomly and samples were available. The data collection tool was a standardized questionnaire.An average of less than 2.5 indicates a low acceptance level, an average of 2.5 to less than 3.75 is considered an average acceptance level, and an average greater than 3.75 to 5 indicates a favorable level of HIS acceptance by users Results: The average variables of the questionnaire in terms of task support dimension, user interface, support for interdisciplinary cooperation and support service dimension are 4.42, 4.05, 4.64, 4.25, respectively, which indicates the level of acceptable acceptance. And in the dimensions of adaptability to tasks, learning ability, and accessibility, respectively, 3.73, 3.07, and 3.59, which indicate the average level of acceptance Conclusion: Officials can increase user satisfaction by providing appropriate platforms in terms of accessibility and learning capabilities, and also by improving hospital information systems, they can significantly save time and increase the quality of services provided in the health care sector
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