Spiritual care helps individuals encounter the transcendent meaning of their crises. However, nurses report various barriers to providing spiritual care in clinical settings. To facilitate spiritual care among nurses, a more comprehensive understanding of this field is needed. This study was conducted to establish a path model for multiple factors predicting spiritual care among nurses working in hospitals. A cross-sectional descriptive design was used. The participants were 370 nurses with more than 6 months of experience working in general hospitals in South Korea. The measures used in this study were nursing workplace spirituality, a spiritual well-being scale, the Maslach Burnout Inventory-Human Services Survey for Medical Personnel, a scale for compassionate care, a general self-efficacy scale, and spiritual care in practice. Path analysis was performed using IBM SPSS Statistics, version 24.0, and SPSS Amos, version 20.0. Workplace spirituality and spiritual well-being predicted higher spiritual care in practice by sequentially mediating burnout and compassionate care. This study suggests that nurses' spiritual care can be increased via the development of specific strategies focused on enhancing the nursing work-place spirituality of hospital organizations, promoting individual spiritual well-being and compassionate behavior, and reducing burnout among nurses. [J Contin Educ Nurs. 2023;54(2):89-96.].