The aim of the study was to identify the effect of nursing guidelines on minimizing the incidence of complications for patients undergoing percutaneous nephrostomy. Research design: A quasi-experimental study design has been used. Setting: The study was carried out, in urologic surgery department and outpatient clinic of urology and . Subjects and methods: Sample: sixty adult patients undergoing PCN were included, having the following criteria; the age between 18 – 65 years, both male and female, and were divided randomly in to study and control groups. The study group (thirty patients) received the nursing guidelines, while the control group (thirty patients) received routine hospital care. Tools: three tools were utilized: Structure interviewing questionnaire, nursing guidelines, and patient evaluation sheet. Results: more than two-thirds of patients in the study group (66.7 %) were male, 86.7% were married, 33.3 % were from (fifty to sixty-five). All patients in both control and study groups don’t complain about urinary tract obstruction. Conclusion: application of the nursing guidelines had its positive impact on the outcomes of patients who underwent percutaneous nephrostomy tube placement. Recommendation: A printed copy of the nursing guidelines is to be distributed among patients with percutaneous nephrostomy tube. A workshop for nurses working in urology operating room is to be organized for enriching nurses with recent guidelines related to percutaneous nephrostomy tube.