Since Bernard Rose’s Candyman (1992) was first released more than 25 years ago, there has been a great deal of scholarly commentary on the film’s treatment of class, race, gender and urban legends. To a lesser degree, Clive Barker’s short story, ‘The Forbidden’ (1986), has received some critical attention largely because of its status as the source material for the film’s general premise and now-iconic central monster. This article expands on such existent scholarship by analysing regional mythologies and the cross-cultural adaptation of place-specific monsters within and across both texts. To develop these primary arguments, this article extracts a theory of adaptation and location from Neil Gaiman’s novel, American Gods ([2001] 2011), and applies that theory to the acts of adaptation pervading ‘The Forbidden’ and Candyman. In complementary ways, all three of these texts explicitly reflect on the complexities of adapting monsters to precise locales. Notably, both American Gods and Candyman take place in the American Midwest; this regional setting greatly impacts the conceptualization of each narrative’s supernatural beings (Gaiman’s cohort of gods and the Candyman, respectively). Within popular culture, the Midwest is regularly depicted as both a site of nostalgic memory and a cultural space defined by the willful forgetting or elision of history. This article asserts the importance of recognizing the Midwest as a recurrent staging ground for horror narratives, particularly those featuring monsters who embody forgotten, misremembered, suppressed or denied pieces of history. Further, by examining such regional dynamics in American Gods and Candyman, this article develops the concept of ‘adaptive monsters’, which describes horrific beings who assume symbolic attributes of the historical, cultural and/or spatial environments into which they are adapted. Overall, through analyses of ‘The Forbidden’, Candyman and American Gods, this article demonstrates how regional mythologies (especially those of the Midwest) shape the adaptation of monstrous beings in horror narratives and across textual forms.