This paper inspects the combined effects of heat and mass transfers in a hybridized Williamson viscous nanofluid composed of cadmium telluride (CdTe) and silicon carbide (SiC) nanoparticles in RT42 (Rubitherm) as base fluid in the existence of heat source and thermal radiative aspects. Knowing that the base fluid RT42 is a phase change material (PCM), it is also considered that the surface on which the nanofluid flows is an expandable surface with varying thickness. The influence of chemical reactions process and viscous dissipation on the flow and temperature of the hybridized nanofluid is examined. The parameters’ influences on the problem are evaluated after setting appropriate similarity transformations to transform the collection of major partial differential equations (PDEs) into nondimensional ordinary differential equations (ODEs). The study concludes that the presence of hybridized nanoparticles of CdTe and SiC reduces the horizontal and vertical surface frictional forces of the hybrid nanofluid. The integration of nanoparticles in RT42 enhances heat transfer rates and reduces mass transfer. The thermal radiative variable declines the heat transfer of hybridized nanofluid. The results indicate that altering the variable parameter of surface thickness reduces frictional forces in both directions.