ABSTRACTMultiple studies have found an inverse relationship between adolescent religiosity and adolescent depression. However, further research is needed to better understand the complexity of this relationship. One potential mediator that may help to explain this relationship is hope. Prior research has found that adolescent religiosity is predictive of increased adolescent hope and that higher levels of adolescent hope have been associated with multiple positive outcomes, including mental health in adolescents. However, no research has explored the mediational role of hope between religiosity and depressive symptoms in adolescents. Cross-sectional data from 459 adolescents were used to test this mediational or indirect effect. The direct effect between religiosity and depressive symptoms was not significant. However, there was a significant indirect effect whereby higher levels of adolescent religiosity were associated with higher levels of adolescent hope, which in turn were associated with lower levels of adolescent depressive symptoms.