Introduction: With the influx of Generation Z (Gen Z) students into pharmacy schools, there are new opportunities for pharmacy educators to develop its greatest asset. Assessing student characteristics is vital in creating pedagogical approaches in education.Commentary: The incoming pharmacy students, Gen Z, are independent and desire active engagement with incorporation of technology in the classroom. These learners have a growth mindset and desire immediate, honest feedback. However, pharmacy educators must evaluate opportunities to facilitate student development related to communication and collaboration to prepare aspiring pharmacists for their future careers.Implications: Pharmacy educators have the ability to harness technology, pedagogical approaches, and skill refinement for Gen Z students to provide the necessary resources and opportunities to facilitate their development into competent, confident, and impactful practitioners to positively influence the profession for years to come.