This study investigates the genetic predisposition to anxiety and its impact on adaptation to the extreme conditions of the North-East region of Russia, particularly concerning the Yakut population. Special attention was given to the polymorphism of the serotonin receptor gene HTR2A (rs6311) and its association with levels of situational anxiety (SA) and personal anxiety (PA). The study involved 261 Yakuts (n = 261) who are permanently residing in Yakutia, do not exhibit any psychoneurological symptoms, and provided voluntary informed consent. Anxiety level was assessed using the Spielberger-Khanin scale. Genotyping was performed using PCR and RFLP, followed by detection through electrophoresis in an agarose gel. The findings indicate that the sample was characterized by a predominance of individuals with moderate levels of SA (60.9 %) and PA (57.5 %). However, in the group of women, individuals exhibited a high level of PA (53.8 %). The highest percentage of agreement in anxiety levels (69.7 %) was observed among individuals with moderate SA and PA. Given that the serotonergic system is involved in regulating behavior, emotions, and various physiological functions, and plays a crucial role in mitigating the negative behavioral consequences of stressors, a study on the polymorphism of the serotonin receptor gene HTR2A (rs6311) was conducted. The analysis of the distribution characteristics of the genotypes and alleles associated with the polymorphism of the serotonin receptor gene HTR2A (rs6311) in the Yakut population revealed a significant predominance of carriers with the homozygous genotype GG (60.2 %), and the G allele (0.782). Futhermore, when examining the distribution of allelic variants of the studied polymorphism based on the level and type of anxiety, it was observed that the AG and GG genotypes were more prevalent among individuals with high PA and low SA. These results confirm the significance of genetic factors in adaptation to the extreme conditions of the North.