Homologous Red Blood Cells Research Articles

Effect of homologous blood components and heterologous lysed red blood cells on dog renal dynamics.

SummaryThe renal vasoconstriction associated with peripheral intravenous infusion of homologous lysed red blood cells in dogs is primarily caused by hemoglobin although the red blood cell stroma appears to have an additive effect. Peripheral intravenous infusion of heterologous lysed red blood cells of human, cow, horse, and sheep origin cause a significant decrease in GFR and ERPF in dogs. Portal vein infusion of heterologous lysed red blood cells through the liver causes a significant decrease in GFR and ERPF in dogs and is frequently associated with moderate decrease in arterial blood pressure. These experiments suggest that the protection afforded the kidney by initial passage of homologous red cell lysates through the liver is due to specific modification of the hemoglobin, a process the liver is unable to perform with heterologous red cell lysates.

Effect of liver on changes in renal dynamics caused by lysed red blood cells.

The effect of an intraportal infusion of homologous lysed red blood cells on GFR and ERPF were recorded in dogs. The significant renal vasoconstriction noted when the lysed red blood cell infusion was administered to a dog via a peripheral (brachial) vein was not present in these dogs receiving the intraportal infusion. Alternate infusion between the portal and brachial veins in individual dog experiments demonstrated a significant depression of GFR and ERPF during the peripheral infusion and insignificant effect during the portal infusion. It is postulated that the active renal vasoconstrictive substance in lysed red blood cells is either delayed, diluted or modified chemically by passage through the liver.