The objective of this study was to assess the knowledge and training on Disaster Risk Reduction among Social Studies teachers’ trainees’ in the Selected Colleges of Education in Ghana. Embedded mixed method and a cross-sectional design was used for the study. The population of the study comprised Social Studies teacher trainees in St. Monicas, Berekum, Tamale, and John Bosco Colleges of Education. Homogenous purposive sampling technique was used to the four (4) Colleges of Education, convenient sampling technique was used to sample three hundred and nineteen (319) for the quantitative data while homogenous purposive sampling technique ten participants for the qualitative data. The main instrument used for data collection were close-ended questionnaire and interview guide. Legitimation process was adopted to ensure validity and reliability of the data collection instrument. The findings of the study revealed that Social Studies teacher trainees possessed low level of disaster risk reduction kits in their schools. The study also indicated that there was low level of extracurricular activities through which DRR knowledge could be impacted, such logistics should be provided by the various college authorities to help them mitigate disasters.. It is therefore recommended that clubs and Social Studies associations on disasters should be formed in the colleges by the college authorities. Discussions and programmes to be carried out in such associations will enable teacher trainees acquire the necessary knowledge and training needed for disaster risk reduction. It is also recommended that discussions should be tailored to reflect the types of risks and disasters which are not only common to all the colleges of education, but also peculiar to each of them.