Attention-Deficit Hyperactivity Disorder (ADHD) or Hyperkinetic Disorder is a neuropsychiatric condition affecting preschoolers, children, adolescents, and adults around the world, characterized by a pattern of diminished sustained attention, and increased impulsivity or hyperactivity. Onset in childhood, probably mediated by decreased brain dopaminergic functioning. We present a case of 6 yrs. old boy reported to outpatient department of National Homoeopathy Research Institute in Mental health, Kottayam. Presenting complaints were restlessness, lack of attention and concentration in studies and impulsivity along with recurrent attack of eczema on feet, who was treated with homoeopathic medicines Tuberculinum and Sulphur. A significant improvement in Vanderbilt ADHD Diagnostic Parent and Teacher Ratings Scales were noted along with positive response in Eczema within one year. It is clearly apparent from this evidence-based case report that homoeopathy has a positive role in the treatment of Hyperkinetic disorder.